Abstract：
:The exposure of cultured rat striatal neurons to L-DOPA caused marked cell death. The L-DOPA cytotoxicity was inhibited by the addition of Mg2+ to and by the removal of Ca2+ from the culture medium, and also by the application of tetrodotoxin. Moreover, prolonged application of L-DOPA increased the glutamate content in the culture medium. These results indicate that L-DOPA produces neurotoxicity by facilitating glutamate release.
journal_name
Brain Resjournal_title
Brain researchauthors
Maeda T,Cheng N,Kume T,Kaneko S,Kouchiyama H,Akaike A,Ueda M,Satoh M,Goshima Y,Misu Ydoi
10.1016/s0006-8993(97)00908-6subject
Has Abstractpub_date
1997-10-10 00:00:00pages
159-62issue
1eissn
0006-8993issn
1872-6240pii
S0006899397009086journal_volume
771pub_type
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