Aversive properties of opiate receptor blockade: evidence for exclusively central mediation in naive and morphine-dependent rats.

abstract：:The olfactory epithelium is comprised of bipolar sensory neurons, sustentacular cells, and basal cells. The sensory neurons have apical knobs and cilia, which project into the olfactory mucus toward the nasal lumen, and represent presumptive sites of odorant binding. Ionic currents, measured across this epithelium in ...

journal_title：Brain research

authors： Kern RC,Kerr TP,Getchell TV

更新日期：1991-04-12 00:00:00

abstract：:We examined the radical-scavenging activity of docosahexaenoic acid (DHA) and its effects on the neuronal cell death induced by oxidative or hypoxic stress in cultured retinal ganglion cells (RGC-5, a rat ganglion cell-line transformed using E1A virus). The radical-scavenging activity [hydrogen peroxide (H(2)O(2)), su...

journal_title：Brain research

authors： Shimazawa M,Nakajima Y,Mashima Y,Hara H

更新日期：2009-01-28 00:00:00

abstract：:Serum-free aggregating cell cultures of fetal rat telencephalon grown in the presence of 3 ng/ml (5 X 10(-10) M) epidermal growth factor (EGF) until day 12 showed 2- to 3-fold increased activities in the two glial enzymes, glutamine synthetase (GLU-S) and 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNPase). This effe...

journal_title：Brain research

authors： Honegger P,Guentert-Lauber B

更新日期：1983-12-01 00:00:00

abstract：:Calpain, a Ca(2+)-dependent cysteine protease, has been implicated in cytoskeletal protein degradation and neurodegeneration in the lesion and adjacent areas following spinal cord injury (SCI). To attenuate apoptosis or programmed cell death (PCD) in SCI, we treated injured rats with E-64-d, a cell permeable and selec...

journal_title：Brain research

authors： Ray SK,Matzelle DC,Wilford GG,Hogan EL,Banik NL

更新日期：2000-06-09 00:00:00

abstract：:When rabbit retinas are exposed in vitro to specific excitatory amino acid receptor agonists certain GABAergic amacrine cells are activated to cause a release of GABA. The GABA that is not released can be detected by immunohistochemistry. Exposure of tissues to kainate or NMDA each caused a characteristic change in th...

journal_title：Brain research

authors： Osborne NN,Pergande G,Block F,Schwarz M

更新日期：1994-12-26 00:00:00

abstract：:Intracranial pressure (ICP) was monitored to evaluate the therapeutic effect of hyperbaric oxygen (HBO(2)) treatment following traumatic brain injury (TBI). This subject is controversial. The aim of our study was to determine whether HBO(2) treatment has a therapeutic effect on ICP dynamics and survival following seve...

journal_title：Brain research

authors： Rogatsky GG,Kamenir Y,Mayevsky A

更新日期：2005-06-21 00:00:00

abstract：:A peripheral nerve lesion performed distally prior to a proximal axotomy is known to result in an increase in the rate of regeneration of both sensory and motor fibres. This phenomenon is called the 'conditioning lesion effect'. The aim of this study was to determine whether or not the kind of the conditioning lesion ...

journal_title：Brain research

authors： Bondoux-Jahan M,Sebille A

更新日期：1986-09-10 00:00:00

abstract：:In order to elucidate the mechanisms that PKCγ regulates neuropathic pain (NP), and detect proteins that are associated with the function of PKCγ in NP, we exploited a chronic constriction injury (CCI)-induced neuropathic pain rat (CCI-NP rat) model in which PKCγ knockdown in the spinal cord was successfully carried o...

journal_title：Brain research

authors： Zou W,Zhan X,Li M,Song Z,Liu C,Peng F,Guo Q

更新日期：2012-02-27 00:00:00

abstract：:The N400 is an event-related potential (ERP) component that is elicited by semantically meaningful stimuli; one of its defining characteristics is that it is amplified for sentence completions that are semantically unexpected or incongruous with the preceding context. Some prior reports using visual sentence reading p...

journal_title：Brain research

authors： Dien J,Michelson CA,Franklin MS

更新日期：2010-10-08 00:00:00

abstract：:Obesity and related metabolic disorders are important side effects of some antipsychotic drugs (APs). The currently available animal model of AP-induced bodyweight gain (BWG) in rats is based on administration of sulpiride (SUL). However, this model has important limitations. For example, SUL is a pure dopamine antago...

journal_title：Brain research

authors： Baptista T,Araujo de Baptista E,Ying Kin NM,Beaulieu S,Walker D,Joober R,Lalonde J,Richard D

更新日期：2002-12-06 00:00:00

abstract：:To examine the effect of short-term and long-term adrenalectomy (ADX) on the glucocorticoid receptor (GR) expression, we performed an immunohistochemical study on the rat forebrain. One day after ADX, the GR-immunoreactivity significantly decreased or disappeared in most forebrain structures, while relatively strong G...

journal_title：Brain research

authors： Visser DT,Hu Z,Pasterkamp RJ,Morimoto M,Kawata M

更新日期：1996-08-12 00:00:00

abstract：:Humans share the common intuition of a self that has access to an inner 'theater of mind' (Baars, 2003). The problem is how this internal theater is formed. Moving from Cook's view (Cook, 2008), we propose that the 'sentience' present in single excitable cells is integrated into units of neurons and glial cells transi...

journal_title：Brain research

authors： Agnati LF,Guidolin D,Cortelli P,Genedani S,Cela-Conde C,Fuxe K

更新日期：2012-10-02 00:00:00

abstract：:There is no sex difference in the number of axodendritic synapses in the lateral septum of adult rats. However, the treatment of adult females with estradiol (E2) for 4 weeks increases significantly the number of synapses, whereas E2 treatment fails to increase the synaptic number in males, suggesting a possible sexua...

journal_title：Brain research

authors： Miyakawa M,Arai Y

更新日期：1987-12-08 00:00:00

abstract：:The growth inhibitory factor (GIF) is a new metallothionein (MT)-like protein that is downregulated in Alzheimer's disease (AD) brain. The biological function of GIF has not been fully clarified yet. We have raised an antibody to the synthetic polypeptide that is specific for rat GIF. The purified antibody reacted to ...

journal_title：Brain research

authors： Hozumi I,Inuzuka T,Hiraiwa M,Uchida Y,Anezaki T,Ishiguro H,Kobayashi H,Uda Y,Miyatake T,Tsuji S

更新日期：1995-08-07 00:00:00

abstract：:Two neuropeptides reacting with antibodies directed against the C-terminal region of somatostatin 28(1-12) were purified to homogeneity from rat brain extracts. Amino acid analysis revealed that the larger peptide (8 kdaltons) consisted of 76 amino acids. Microsequencing established its aminoterminal structure as: Ala...

journal_title：Brain research

authors： Benoit R,Böhlen P,Esch F,Ling N

更新日期：1984-10-08 00:00:00

abstract：:There is evidence that acute exposure to kainic acid (KA) induces the release of endogenous ligands for opioid receptors and that mu-opioid agonists intensify KA-induced neurodegeneration. The aim of the present study was to investigate any acute toxic effects of KA upon mu-opioid receptors labelled with [3H]-DAMGO. 2...

journal_title：Brain research

authors： Ridd MJ,Fosbraey P,Kitchen I

更新日期：1998-12-14 00:00:00

abstract：:Retrogradely labeled neurons are observed in the central nervous system of the toad after peripheral application of peroxidase to the anterior and posterior stumps of the VIIIth nerve. These efferent vestibular neurons are localized in the brainstem only ipsilaterally to the treated nerve; they are restricted within a...

journal_title：Brain research

authors： Pellegrini M,Ceccotti F,Magherini P

更新日期：1985-09-30 00:00:00

abstract：:Transforming growth factor-alpha (TGF-alpha) has been identified as a potential output signal of the principal circadian pacemaker housed in the mammalian suprachiasmatic nucleus (SCN). The goal of the present study was to characterize the temporal pattern and cellular localization of TGF-alpha immunoreactivity (IR), ...

journal_title：Brain research

authors： Lindley J,Deurveilher S,Rusak B,Semba K

更新日期：2008-03-04 00:00:00

abstract：:The effects of induced L9 activity on gill motor neuron L7's ability to elicit a gill withdrawal response were studied. It was found that L9 was a modulator of L7's effectiveness to elicit gill movements. Following L9 activity, L7's ability to elicit a gill withdrawal response was significantly potentiated by up to 24...

journal_title：Brain research

authors： Lukowiak K

更新日期：1979-03-16 00:00:00

abstract：:Electroconvulsive stimulation (ECS), the experimental analogue of electroconvulsive therapy (ECT), has been shown to produce both functional and structural effects in the hippocampal formation in infrahuman species. These changes may relate to the antidepressant and cognitive effects of ECT observed in patients treate...

journal_title：Brain research

authors： Lamont SR,Stanwell BJ,Hill R,Reid IC,Stewart CA

更新日期：2005-08-16 00:00:00

abstract：:Several investigations have shown that the N-methyl-D-aspartate (NMDA) antagonist MK-801 interferes both with learning and a candidate neural mechanism for learning, the long-term potentiation (LTP) phenomenon. The low doses of MK-801 reported to block learning, however, may not be sufficient to block LTP. The present...

journal_title：Brain research

authors： Robinson GB,Reed GD

更新日期：1992-01-08 00:00:00

abstract：:Somatosensory information has been thought to ascend from the spinal cord to limbic areas of the telencephalon through indirect, multisynaptic pathways. We now report that injections of Fluoro-gold into either the nucleus accumbens or the septal nuclei labeled hundreds of neurons in the spinal cord. These and our rece...

journal_title：Brain research

authors： Burstein R,Giesler GJ Jr

更新日期：1989-09-11 00:00:00

abstract：:Neurotensin (NT), a tridecapeptide, is a neurotransmitter that elicits potent effects including hypothermia and antinociception in mice and rats. To date, there are two types of the neurotensin receptor (NTR) that have been molecularly cloned from the rat. However, several lines of evidence suggest the presence of add...

journal_title：Brain research

authors： Tyler BM,Cusack B,Douglas CL,Souder T,Richelson E

更新日期：1998-05-11 00:00:00

abstract：:In order to establish the basic connectivity of physiologically identified somatosensory regions of the thalamus and telencephalon in the pigeon, injections of wheatgerm agglutinin-horseradish peroxidase were made under electrophysiological control and the projections were charted following conventional neurohistochem...

journal_title：Brain research

authors： Wild JM

更新日期：1987-06-02 00:00:00

abstract：:The effects of the putative dopaminergic antagonist, haloperidol (0.01-10 mg/kg, i.v.), on cerebral glucose utilization in 43 anatomically discrete regions of the rat brain have been examined by the quantitative autoradiographic 2-deoxyglucose technique. Dose-dependent reductions in glucose utilization were observed i...

journal_title：Brain research

authors： McCulloch J,Savaki HE,Sokoloff L

更新日期：1982-07-08 00:00:00

abstract：:Rats treated neonatally with pargyline and 5,7-dihydroxytryptamine (5,7-DHT) have an elevated paCO2 and reduced minute ventilation when given 0.7% halothane in oxygen as adults. Serotonin content in the spinal cord of 5,7-DHT treated rats was undetectable and TRH content was reduced by 35%. The 5,7-DHT treated rats we...

journal_title：Brain research

authors： Mueller RA,Towle AC,Breese GR

更新日期：1984-04-30 00:00:00

abstract：:The response of neurons in the preoptic and adjacent regions of the brain to intracarotid injection of hyperosmotic solutions was studied in 22 anesthetized cats. NaCl (0.5 M) caused a brisk acceleration of frequency lasting over 100 s in 120 of 207 units (58%). Glucose (2 M) and sucrose (2 M) had similar but smaller ...

journal_title：Brain research

authors： Hubbard JI,Mills RG,Sirett NE

更新日期：1985-10-21 00:00:00

abstract：:Voltage-gated potassium (Kv) channels are essential components of neuronal excitability. The Kv3.4 channel protein is widely distributed throughout the central nervous system (CNS), where it can form heteromeric or homomeric Kv3 channels. Electrophysiological studies reported here highlight a functional role for this ...

journal_title：Brain research

authors： Dallas ML,Morris NP,Lewis DI,Deuchars SA,Deuchars J

更新日期：2008-01-16 00:00:00

abstract：:Cytochemistry was used to examine the distribution of two pathways of utilization of hydrogen (Type I and Type II H) generated by glucose-6-phosphate dehydrogenase (G6PD) in circumventricular organs (CVOs) and the hypothalamo-neurohypophysial system in cryostat sections of rat brain. Type I H is defined as that portio...

journal_title：Brain research

authors： Summy-Long JY,Salisbury R,Marietta MP,Hartman RD,Weisz J

更新日期：1984-02-27 00:00:00

abstract：:Performance on object recognition and object placement memory tasks was evaluated after a short-dosing model of methamphetamine (MA) regime and monoamines and metabolites were measured post-testing. Adult male rats received three injections of 10 mg/kg at 2-h intervals. In striatum DA and 5-HT were depleted by 65% and...

journal_title：Brain research

authors： Bisagno V,Ferguson D,Luine VN

更新日期：2002-06-14 00:00:00