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Electrophysiological study of conditioning lesion effect on rat sciatic nerve regeneration following either prior section or freeze. I. Intensity and time course.

Abstract：

:A peripheral nerve lesion performed distally prior to a proximal axotomy is known to result in an increase in the rate of regeneration of both sensory and motor fibres. This phenomenon is called the 'conditioning lesion effect'. The aim of this study was to determine whether or not the kind of the conditioning lesion influences the intensity and the time course of the conditioning lesion effect. The prior lesion was performed on the tibial nerve of rats at the ankle either by cutting the nerve or freezing it by means of a 1 mm diameter liquid nitrogen cryod. At several points in time up to 28 days a second (or test) lesion consisting of a freeze was performed on the sciatic nerve at the middle part of the thigh. The regeneration of the fastest growing fibres of the sciatic nerve was measured electrophysiologically 5, 7 and 9 days after the test lesion. The nerve was surgically removed, immediately mounted in a recording nerve chamber and stimulated proximally to the test lesion. The distance between the test lesion and the most distal point where an evoked nerve potential was detectable was taken as the regenerated nerve length. Then the rate of regeneration was calculated and the initial delay was estimated by means of a linear regression plotting the regenerated nerve lengths against the days of recording. All the results were compared to those of a control group where the test lesion alone was performed. The increase in the maximal rate of regeneration was greater following a prior section (+25%) than following a prior freeze (+12%). Following a prior section, the rate of regeneration began to be significantly increased for a conditioning interval of 4 days, and went on until a conditioning interval of 28 days. By contrast, after a prior freeze the rate of regeneration was significantly increased solely for an interval of 14 days.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Brain Res

journal_title

Brain research

authors

Bondoux-Jahan M,Sebille A

doi

10.1016/0006-8993(86)90108-3

subject

Has Abstract

pub_date

1986-09-10 00:00:00

pages

39-45

issue

eissn

0006-8993

issn

1872-6240

pii

0006-8993(86)90108-3

journal_volume

382

pub_type

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Electrophysiological study of conditioning lesion effect on rat sciatic nerve regeneration following either prior section or freeze. I. Intensity and time course.