Abstract:
:The purpose of this study was to investigate the cannabinoid and opioid mediated regulation on the effects of central Delta(9)-tetrahydrocannabinol (Delta(9)-THC) administration on hypothalamus-pituitary-adrenal (HPA) axis activity in the male rat. Intracerebroventricular (i.c.v.) administration of delta(9)-THC (25, 50, 100 microg/rat) markedly increased plasma adrenocorticotropin hormone (ACTH) and corticosterone concentrations. Time course effect studies revealed that both hormones secretion peaked at 60 min after Delta(9)-THC i.c.v. administration (50 microg/rat), decreased gradually and returned to baseline levels by 480 min. The i.c.v. administration of the specific cannabinoid receptor antagonist SR-141716A (3 microg/rat) significantly attenuated the increase of both hormones secretion induced by Delta(9)-THC (50 microg/rat). Nevertheless, higher doses (12.5 and 50 microg/rat) of this compound increased both ACTH and corticosterone plasma concentrations. Subcutaneous (s.c.) administration with the opiate receptor antagonist naloxone (0.3 mg/kg) was without effect but significantly diminished the increase of both hormones secretion induced by Delta(9)-THC (50 microg/rat). Taken together, these results indicate that opiate and cannabinoid receptors are involved in the activation of the HPA axis induced by Delta(9)-THC. Furthermore, the increase of ACTH and corticosterone secretion after the administration of higher doses of SR-141716A than those required to block such activation, suggests that endogenous cannabinoids are tonically inhibiting the release of both hormones or that this agonist-like activity may be part of an uncharacterized action of this compound not mediated by cannabinoid receptors.
journal_name
Brain Resjournal_title
Brain researchauthors
Manzanares J,Corchero J,Fuentes JAdoi
10.1016/s0006-8993(99)01756-4subject
Has Abstractpub_date
1999-08-21 00:00:00pages
173-9issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(99)01756-4journal_volume
839pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Phosphocreatine-Mg-complex acetate (PCr-Mg-CPLX) is a creatine-derived compound that in previous in vitro research was able to increase neuronal creatine independently of the creatine transporter, thus providing hope to cure the hereditary syndrome of creatine transporter deficiency. In previous research we showed tha...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.06.009
更新日期:2009-08-18 00:00:00
abstract::We previously reported that planarians (Dugesia dorotocephala) that have been exposed to cocaine for 1 h undergo abstinence-induced withdrawal when placed into cocaine-free, but not cocaine-containing, water. We now report that planarians also display dose-related abstinence-induced withdrawal following exposure to th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.04.103
更新日期:2006-07-12 00:00:00
abstract::The distribution of calretinin containing neurons examined by in situ hybridization mapping was compared with that obtained by immunocytochemistry in the brain of octopus. Results revealed a close correspondence between the two types of investigations. Western blot analysis disclosed a 29 kDa protein immunostained wit...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.11.056
更新日期:2007-02-09 00:00:00
abstract::By use of the push-pull perfusion technique, release of neuronal cholecystokinin-like immunoreactivity (CCK-LI) from hypothalamus of owl monkeys was investigated in relation to an intragastric meal. In overnight fasted, halothane-anesthetized owl monkeys, levels of CCK-LI in the hypothalamic push-pull perfusate were b...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90957-7
更新日期:1987-08-18 00:00:00
abstract::The development of brain stem reticular core neurons in prenatally undernourished rats was investigated using the Golgi technique to determine the effect of immediate postnatal nutritional rehabilitation. Quantitative measurements of dendritic extent of branching and of cell size were compared in experimental and cont...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(81)90108-5
更新日期:1981-04-01 00:00:00
abstract::Blockade of gamma-aminobutyric acid (GABA) function in the posterior hypothalamus of rats elicits a pattern of physiological and behavioral arousal consisting of increases in heart rate, respiration and blood pressure as well as intense locomotor stimulation and a selective enhancement of avoidance responding. The pre...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91173-e
更新日期:1990-03-26 00:00:00
abstract::Individual vulnerability to the reinforcing effects of drugs appear to be a crucial factor in the development of addiction in humans. In the rat, individuals at risk for psychostimulant self-administration (SA) may be identified from their locomotor reactivity to a stress situation such as exposure to a novel environm...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91452-7
更新日期:1991-12-13 00:00:00
abstract::Previous studies have demonstrated that food restriction during lactation extends the length of lactational infertility in rats. In order to determine whether Neuropeptide Y (NPY) plays a role in the increased length of lactational infertility seen in food-restricted rats, NPY immunoreactivity in the arcuate nucleus o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00351-x
更新日期:1997-07-04 00:00:00
abstract::Recordings of single unit activity before, during and after a 1-h continuous exposure were made from the mitral cell layer of the olfactory bulbs of awake rabbits. Thirteen complete 1-h exposures were performed using 8 neurons, while a further 6 neurons were lost before the end of the exposure. During the first few mi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90951-9
更新日期:1982-10-28 00:00:00
abstract::The study investigated the effect of aminoguanidine (AG) on inducible nitric oxide synthase (iNOS), aquaporin-4 (AQP4), malondialdehyde (MDA) and glutathione (GSH) levels in surgical brain injury (SBI) in rats. AG (75, 150 and 300 mg/kg, i.p.) was administered immediately following surgical resection. Using an SBI mod...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.05.041
更新日期:2009-07-28 00:00:00
abstract::Spreading depression (SD) is characterized by a transient breakdown of neuronal function concomitant with a massive failure of ion homeostasis. It is a phenomenon that can be induced in neocortical tissue by raising excitability, e.g. injection of K(+), application of glutamatergic agonists, or blocking Na(+)/K(+) ATP...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02600-3
更新日期:2003-06-13 00:00:00
abstract::Glutamate carboxypeptidase II may modulate excitatory neurotransmission through the catabolism of the neuropeptide N-acetylaspartylglutamate (NAAG) and possibly other endogenous peptide substrates. To investigate the molecular properties of cloned human GCP II (hGCP II), we analyzed the NAAG-hydrolytic activity convey...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00244-3
更新日期:1998-06-08 00:00:00
abstract::Rapid eye movement (REM) sleep is hypothesized to result from the activity of REM sleep-generating and REM sleep-inhibiting neurons. The serotoninergic (5-HT) neurons of the dorsal raphe nucleus (DRN) represents one such population of REM-sleep inhibiting neurons since they are silent during REM sleep. Consistent with...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03209-7
更新日期:2001-12-27 00:00:00
abstract::Cardiovascular responses to electrical microstimulation of the ventrolateral medulla were investigated in both Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) under pentobarbital anesthesia. The threshold intensity required to elicit a change in blood pressure (BP) and the cardiovascular responses in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91582-2
更新日期:1990-07-02 00:00:00
abstract::Investigations of the time course of various stages of lexical processing have indicated either early or late onset of brain activation for phonological code retrieval. The basis of the differential findings is unclear, but factors related to segmental phonology appear to be part of it. The purpose of the present stud...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.01.014
更新日期:2016-03-15 00:00:00
abstract::High-affinity uptake of norepinephrine (NE) and dopamine (DA) were determined in synaptosomes of brain regions from four genetically related inbred rat strains, all derived from the Wistar-Kyoto rat: SHR, WKY, WKHA and WKHT strains. SHRs express hypertension and hyperactivity, WKHAs express hyperactivity alone, WKHTs ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91369-p
更新日期:1992-07-17 00:00:00
abstract:OBJECTIVE:Previously, we found that the inhaled anesthetic isoflurane up-regulated the transcriptional factor hypoxia inducible factor (HIF)-1α protein levels during induction of neurodegeneration in the brain of neonatal rats. Here, we investigated the role of HIF-1α and the underlying signaling pathway in the neurode...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.10.014
更新日期:2016-12-15 00:00:00
abstract::Physical activity has been related to antioxidant adaptations, which is associated with health benefits, including those to the nervous system. Additionally, available data suggest exercise and a caloric restriction regimen may reduce both the incidence and severity of neurological disorders. Therefore, our aim was to...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.08.003
更新日期:2011-11-03 00:00:00
abstract::Nuclear factor kappa B (NFkappaB) is a transcription factor which can be activated by some neurotrophic factors and cytokines, and then translocated into the nucleus. We examined NFkappaB immunoreactivity (IR) in L4 and L5 dorsal root ganglion (DRG) cells of normal rats, and 2 weeks after complete sciatic nerve transe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00380-1
更新日期:1998-06-29 00:00:00
abstract::We have recently demonstrated that the formation of myelin sheaths in the optic nerve of young postnatal mice deficient in the myelin-associated glycoprotein (MAG) is retarded when compared to age-matched wild-type mice. In the present study, we analyzed whether impaired myelination of retinal ganglion cell axons is d...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00484-8
更新日期:1997-07-11 00:00:00
abstract::c-Fos protein is a nuclear protein coded by c-fos proto-oncogene subsequent to synaptic activation of the neurons. We used immunohistochemical methods to visualize the expression of c-Fos protein in myenteric neurons of the guinea pig distal colon and examined the effects of the extrinsic autonomic inputs on the enter...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02943-8
更新日期:2002-09-06 00:00:00
abstract::Receptor subunit composition is believed to play a major role in the synaptic trafficking of AMPA receptors (AMPARs), and thus in activity-dependent synaptic plasticity. To isolate a physiological role of GluA1-containing AMPARs in area CA3 of the hippocampus, pair recordings were performed in organotypic hippocampal ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.11.029
更新日期:2012-01-30 00:00:00
abstract::The synaptic protein alpha-synuclein is found throughout the brain, although its function remains ill-defined. Abnormal accumulations of alpha-synuclein have been recognised to be associated with a number of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Nevertheless, little is know...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.10.072
更新日期:2004-04-09 00:00:00
abstract::A method for selectively labeling the CNS neurons that give rise to zinc-containing axonal boutons is described. Focal intracerebral infusions of selenium anions are used to produce a precipitate (presumably ZnSe) in zinc-containing axonal boutons at the injection site, and within 24-48 h, the precipitate is transport...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90607-d
更新日期:1990-05-07 00:00:00
abstract::The therapeutic effects of dextrorphan and ketamine, two non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, on neuropathic pain-related behaviors were examined in rats with peripheral mononeuropathy induced by loose ligation of the common sciatic nerve (chronic constrictive injury, CCI). Four daily intr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91368-3
更新日期:1993-03-05 00:00:00
abstract::The divalent cation zinc has been reported to possess several physiological properties such as blocking apoptotic cell death through an inhibitory effect on Ca(2+)-Mg2+ endonuclease activity, or modulating the neurotoxicity via glutamate receptor subtypes. In the present study, we investigated the effect of peripheral...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01112-2
更新日期:1996-12-16 00:00:00
abstract::Stressors produce rapid activation of the hypothalamic-pituitary-adrenal axis, which typically resolves within 60-90 min following termination of the stressor. In addition, some stressors such as inescapable tailshock (IS) also produce elevated basal levels of corticosterone (CORT), and reduced serum levels of cortico...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02050-8
更新日期:1999-11-20 00:00:00
abstract::Maternal infection during pregnancy is associated with an increased risk of neurodevelopmental injury. Our aim was to investigate whether prenatal immune challenge could alter susceptibility to seizure-induced brain injury in adulthood. Pregnant Wistar rats were injected intraperitoneally with lipopolysaccharide (LPS)...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.04.047
更新日期:2013-06-26 00:00:00
abstract::A single electrode voltage clamp was used to examine the prolonged hyperpolarizing afterpotential (PHA) which accompanies photoconversion of a substantial fraction of rhodopsin (lambda max = 500 nM) to metarhodopsin (lambda max = 575 nM) in distal photoreceptor cells in the retina of the bay scallop, Pecten irradians....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90539-x
更新日期:1982-05-13 00:00:00
abstract::Mild acute hypertension was induced in rats pharmacologically and non-pharmacologically with metaraminol, angiotensin II or bilateral vagotomy. The extraction fraction of water (Ew) was measured in both hypertensive and normotensive animals. It was demonstrated that cerebral blood flow did not change during hypertensi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91069-2
更新日期:1984-08-13 00:00:00