Abstract：
:Nuclear factor kappa B (NFkappaB) is a transcription factor which can be activated by some neurotrophic factors and cytokines, and then translocated into the nucleus. We examined NFkappaB immunoreactivity (IR) in L4 and L5 dorsal root ganglion (DRG) cells of normal rats, and 2 weeks after complete sciatic nerve transection (CSNT), partial sciatic nerve ligation (PSNL) and chronic constriction injury (CCI). In the normal DRG, 45% of the neurons were NFkappaB-IR (IR in cytoplasm only or in both cytoplasm and nucleus). Only 18% were activated NFkappaB-IR cells (IR in both cytoplasm and nucleus). Two weeks after CSNT, PSNL and CCI, there was no significant difference in the percentages of NFkappaB-IR neurons between the ipsilateral and contralateral DRG. However, the percentages of the activated NFkappaB-IR neurons in the ipsilateral DRG of PSNL (30%) and CCI (33%) rats, but not in CSNT (24%) rats, were significantly increased, compared with the contralateral DRG. Ultrastructurally, NFkappaB-IR was localized to the endoplasmic reticulum and Golgi apparatus. In activated cells, IR was also observed in the nuclei. Two weeks after CCI, NFkappaB-IR was stronger in the axons and Schwann cells in the proximal stump of the injured sciatic nerves than in uninjured contralateral nerves. In some Schwann cells surrounding unmyelinated fibers, the nuclei were also NFkappaB-IR, suggesting that these cells were activated by CCI. NFkappaB activation increased in DRG neurons and Schwann cells 2 weeks following partial sciatic injuries, possibly in response to cytokines and neurotrophins produced by endoneurial cells in the partially injured nerve during Wallerian degeneration.
journal_name
Brain Resjournal_title
Brain researchauthors
Ma W,Bisby MAdoi
10.1016/s0006-8993(98)00380-1subject
Has Abstractpub_date
1998-06-29 00:00:00pages
243-54issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(98)00380-1journal_volume
797pub_type
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