Sodium dodecylsulphate induces a breach in the blood-brain barrier and enables a West Nile virus variant to penetrate into mouse brain.

Abstract:

:A novel and convenient assay was used to determine the effect of recombinant Interleukin-2 (IL-2) on the function of the blood-brain barrier (BBB). The assay is based on a variant of the West Nile virus, WN-25, which had lost its neuroinvasiveness but not its neurovirulence. WN-25, when injected intravenously, can cause the death of mice only if the function of the BBB is impaired. Sodium dodecylsulphate (SDS), a component in IL-2 excipient, was found to cause a short term breach in the BBB, enabling the penetration of viruses into the brain. Minimal amounts (30 ng/mouse) can induce a breach of about 10 min, which allows 0.1% of the injected virus to enter the brain. These findings demonstrate the possible use of SDS as a mean for intentional introduction of drugs into the brain, however they also call attention to the danger of using detergents as additives for drugs given intravenously.

journal_name

Brain Res

journal_title

Brain research

authors

Kobiler D,Lustig S,Gozes Y,Ben-Nathan D,Akov Y

doi

10.1016/0006-8993(89)91079-2

subject

Has Abstract

pub_date

1989-09-04 00:00:00

pages

314-6

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(89)91079-2

journal_volume

496

pub_type

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