Adenosine receptor antagonists potentiate dopamine receptor agonist-induced rotational behavior in 6-hydroxydopamine-lesioned rats.

Abstract:

:Adenosine receptor antagonists, DMPX, PACPX and theophylline, produce contralateral rotations in unilateral 6-hydroxydopamine-lesioned rats. DMPX and theophylline markedly increase rotations produced by bromocriptine (a dopamine D2 receptor agonist) and/or SKF38393A (a dopamine D1 receptor agonist). All of these effects are inhibited by CGS21680C (an adenosine A2 receptor agonist). These findings suggest synergistic interactions among D1, D2 and A2 receptors that may be relevant to the treatment of Parkinson's disease.

journal_name

Brain Res

journal_title

Brain research

authors

Jiang H,Jackson-Lewis V,Muthane U,Dollison A,Ferreira M,Espinosa A,Parsons B,Przedborski S

doi

10.1016/0006-8993(93)90925-d

subject

Has Abstract

pub_date

1993-06-11 00:00:00

pages

347-51

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(93)90925-D

journal_volume

613

pub_type

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