Abstract:
:Ion-sensitive microelectrodes were used to study the behavior of extracellular ions in rat sciatic nerve during and following activity. Nerve stimulation produced increases in [K+]o that were dependent upon the frequency and duration of stimulation; no change in extracellular pH occurred with stimulation. Increases in [K+]o depended on axonal discharge since they were blocked by inhibiting sodium channels with tetrodotoxin. At 22 degrees C, stimulation could induce increases in [K+]o of several mM; at 36 degrees C, stimulation rarely produced increases in [K+]o greater than 1 mM. Stimulated increases in [K+]o dissipated very slowly (i.e. t 1/2 = 50-100 s) and the rate of dissipation was not significantly affected by anoxia, changes in temperature, changes in extracellular pH, or the application of a blocker of Na+, K(+)-ATPase (ouabain) or a K+ channel blocker (Ba2+). In comparison to the central nervous system, neural activity in rat sciatic nerve produced smaller increases in [K+]o and these increases dissipated much more slowly. The primary mechanism of K+ dissipation appeared to be diffusion, probably facilitated by the larger extracellular space in peripheral nerve compared to the central nervous system, but impeded by diffusion barriers imposed by the blood-nerve barrier.
journal_name
Brain Resjournal_title
Brain researchauthors
Hoppe D,Chvatal A,Kettenmann H,Orkand RK,Ransom BRdoi
10.1016/0006-8993(91)90666-jsubject
Has Abstractpub_date
1991-06-21 00:00:00pages
106-12issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(91)90666-Jjournal_volume
552pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Experiments were performed to test the hypothesis that subarachnoid hemorrhage (SAH) causes functionally relevant perturbations of cyclooxygenase activity in cerebral arteries. Four groups of rabbits were formed: (I) controls; (II) sham injected animals (2 ml physiological solution in the cisterna magna); (III) SAH gr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00053-5
更新日期:1998-04-20 00:00:00
abstract::The effect of high acetaldehyde (ACe) on acetylcholine (ACh) release was studied in vivo in the medial frontal cortex (mfc) of freely moving rats using brain microdialysis coupled with high performance liquid chromatography and an electrochemical detector. Ethanol (EtOH) and ACe concentrations were quantified simultan...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.01.049
更新日期:2005-03-28 00:00:00
abstract::Male laboratory rats were raised in two colonies, each of 27 rats, and then given intraventricular injections of the norepinephrine neurotoxin 6-hydroxydopamine (6-OHDA) or the serotonin neurotoxin 5,6-dihydroxytryptamine (5,6-DHT) or saline. They were then returned to their enclosure and behavior during the next 50 d...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90688-0
更新日期:1976-02-13 00:00:00
abstract::Mild acute hypertension was induced in rats pharmacologically and non-pharmacologically with metaraminol, angiotensin II or bilateral vagotomy. The extraction fraction of water (Ew) was measured in both hypertensive and normotensive animals. It was demonstrated that cerebral blood flow did not change during hypertensi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91069-2
更新日期:1984-08-13 00:00:00
abstract::Circadian and neural mechanisms important for the organization of reproductive behavior in the male golden hamster were examined. The sexual behavior of male hamsters exhibits diel variations; males are quicker to initiate copulation and to ejaculate in the dark phase than in the light phase of a daily light-dark cycl...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91460-4
更新日期:1984-02-13 00:00:00
abstract::The content and turnover of dopamine, norepinephrine and 5-hydroxytryptamine (serotonin), and the content of their respective major metabolites were evaluated in 19 discrete brain areas of rats exposed to conditioned emotional response (CER), and in control groups which received either equivalent yoked shock (shock on...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90647-3
更新日期:1982-05-20 00:00:00
abstract::In many persons with temporal lobe epilepsy, dentate granule cells form an interconnected synaptic network. This recurrent mossy fiber circuit mediates reverberating excitation that may facilitate seizure propagation by synchronizing granule cell discharge. The involvement of specific glutamate receptors in granule ce...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02824-4
更新日期:2001-10-05 00:00:00
abstract::We are interested in studying the co-localization of NMDA glutamate receptor subunits (NR1, NR2A/B) and AMPA glutamate receptor subunits (GluR1, GluR2, GluR2/3 and GluR4) in individual neurons of the rat vestibular nuclei. Immunoreactivity for NR1, NR2A/B, GluR1, GluR2, GluR2/3 and GluR4 was found in the somata and de...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02913-9
更新日期:2000-11-24 00:00:00
abstract::We investigated whether somatostain modulates the generation of long-term potentiation (LTP) in rat perforant path-dentate gyrus synapse in vivo. When somatostatin was injected intracerebroventricularly (i.c.v.) 20 min prior to the tetanus, the intensity of LTP increased dose dependently. Synaptic potential evoked by ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00233-8
更新日期:1996-06-03 00:00:00
abstract::The effect of gamma-aminobutyric acid (GABA)receptor stimulation on norepinephrine (NE)-induced metabolism of polyphosphoinositides (PIPs) was studied in rat hippocampal slices. Inositol phosphates (IPs), PIPs, and phosphatidic acid were measured. NE induced formation of IPs and phosphatidic acid in a dose-dependent m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90701-3
更新日期:1987-05-12 00:00:00
abstract::In the diseased central nervous system, astrogliosis is accompanied by microglial activation. Depending on the context of their activation, reactive astrocytes are involved in neuronal survival and regeneration in an either protective or impedimental way. Major reactive changes of astrocytes in vivo are the upregulati...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.10.057
更新日期:2007-01-19 00:00:00
abstract::Parvalbumin (PV) and calbindin (CB) immunoreactivities were assessed in nucleus robustus archistriatalis (RA) of male and female zebra finches, together with retrograde labelling of RA neurons. The results of double and triple labelling experiments suggested that, in males, moderately and faintly PV-positive neurons w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02938-9
更新日期:2001-11-02 00:00:00
abstract::Gastrin-releasing peptide (GRP) mediated signals in the central nervous system (CNS) influence many functions associated with energy metabolism. The purpose of the present study was to investigate the central effect of GRP on glucose metabolism in the male rat. Intracerebroventricular (icv) administration of GRP cause...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.08.040
更新日期:2015-11-02 00:00:00
abstract::The transcription factor Phox2b is necessary for the development of the nucleus of the solitary tract (NTS). In this brainstem nucleus, Phox2b is expressed exclusively within a subpopulation of glutamatergic neurons. The present experiments in the adult rat were designed to test whether this subpopulation includes the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.05.072
更新日期:2008-08-21 00:00:00
abstract::Diffuse white matter (WM) response to traumatic brain injury (TBI) and transplantation of human bone marrow stromal cells (hMSCs) after the injury were non-invasively and dynamically investigated. Male Wistar rats (300-350 g) subjected to TBI were intravenously injected with 1 ml of saline (n = 10) or with hMSCs in su...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.04.020
更新日期:2019-08-15 00:00:00
abstract::Morphological, electrophysiological and behavioral studies were carried out in cats after unilateral kainic acid injection in the substantia nigra. A forced contralateral head turning and compulsive circling was observed after surgery. Fifteen days after, when asymmetry disappeared, apomorphine induced an ipsilateral ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91002-x
更新日期:1987-03-03 00:00:00
abstract::Altered dopamine regulation in the medial prefrontal cortex has been linked to drug abuse and disorders such as schizophrenia. Heterogeneous expression of the dopamine transporter, as well as the ability of the norepinephrine transporter to clear dopamine in the prefrontal cortex, delineates two potential sites for th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02542-8
更新日期:2002-05-17 00:00:00
abstract::After spinal cord injury (SCI), the rapidly upregulated chondroitin sulfate proteoglycans (CSPGs), the prominent chemical constituents and main repulsive factors of the glial scar, play an important role in the extremely limited ability to regenerate in adult mammals. Although many methods to overcome the inhibition h...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.08.048
更新日期:2014-10-24 00:00:00
abstract::We developed a new model of embolic cerebral ischemia in the rat which provides a reproducible and predictable infarct volume within the territory supplied by the middle cerebral artery (MCA). The MCA was occluded by an embolus in Wistar rats (n = 71). An additional three non-embolized rats were used as a control. Cer...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00580-5
更新日期:1997-08-22 00:00:00
abstract::The organization of globus pallidus (GP) projections was studied in cats using autoradiographic and horseradish peroxidase (HRP) techniques. Both methods confirmed the existence of a topographically organized projection to subthalamic nucleus (STN). Although all but the most caudal GP projects to STN, the heaviest pro...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90003-7
更新日期:1980-05-05 00:00:00
abstract::Albino rats received 10 s of sub-seizure electrical stimulation applied to the dentate gyrus granule cells immediately after acquisition of information on trial 1 of a 2-trial radial maze spatial memory task. Granule cell stimulation selectively reduced the probability of accessing information held in declarative memo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90166-5
更新日期:1984-09-24 00:00:00
abstract::Sleep spindles may be involved in synaptic plasticity. Learning-dependent increases in spindles have been observed in both humans and rats. In humans, the innate (i.e., baseline) number of spindles correlate with measures of academic potential such as Intelligence Quotient (IQ) tests. The present study investigated if...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.01.026
更新日期:2010-03-10 00:00:00
abstract::The motivational effects of exclusively peripheral or central opiate receptor blockade were studied using place conditioning. Place aversions were observed with intraventricular (i.c.v.) methylnaloxone (MN) in both naive (200-1000 ng) and morphine-dependent rats (50-500 ng). Subcutaneous MN (0.03-10 mg/kg) was ineffec...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90452-0
更新日期:1988-12-06 00:00:00
abstract::The ability of heterotopic noxious stimuli to inhibit the activity of dorsal horn convergent neurones was investigated in both intact anesthetized, and spinal unanesthetized rats. Forty-four convergent neurones in lumbar dorsal horn were recognized by their ability to respond to both noxious and non-noxious natural st...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90412-2
更新日期:1983-09-19 00:00:00
abstract::The effects of oral administration of the neuroleptic, haloperidol, on regional brain concentrations of cholecystokinin (CCK) and neurotensin were examined in the rat. Both short-term (3 weeks) and long-term (8 months) haloperidol administration increased the concentration of CCK in the substantia nigra. While short-t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91580-1
更新日期:1989-02-20 00:00:00
abstract::Changes in the partial pressure of arterial CO2 (PaCO2) regulates cerebrovascular tone and dynamic cerebral autoregulation (CA). Elevations in PaCO2 also increases autonomic neural activity and may alter the arterial baroreflex. We hypothesized that hypercapnia would impair, and hypocapnia would improve, dynamic CA an...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.07.048
更新日期:2008-09-16 00:00:00
abstract::The acute effects of ethanol on the gamma-aminobutyric acid (GABA)-activated current were studied with the rat dorsal root ganglion neurons in primary culture using the whole-cell patch-clamp technique. GABA produced an inward chloride current, which was composed of an initial transient and a subsequent sustained phas...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90982-h
更新日期:1990-06-04 00:00:00
abstract::Nerve growth factor (NGF) treatment, given as a single 200 BU intraocular injection at the time of optic nerve transection, was found to significantly accelerate the retinal ganglion cell response to axotomy in the newt (Notophthalmus viridescens). In the control series the per cent of neurons in the retinal ganglion ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90327-5
更新日期:1979-08-03 00:00:00
abstract::Previous research has shown that injection of morphine into the ventral tegmental area (VTA) facilitates the onset of maternal behavior in virgin female rats, and injection of the opioid antagonist naltrexone into the VTA disrupts the onset of maternal behavior in parturient rats. Placentophagia -- ingestion of placen...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.01.015
更新日期:2009-03-19 00:00:00
abstract::Epileptic discharge patterns in an acute experimental model of epilepsy were analyzed. Epileptic foci were induced by epicortical application of penicillin on the rat motor cortex in vivo. Patterns with regular 1/s discharges, patterns with irregular discharges of about 0.5/s as well as compound patterns comprising di...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90221-8
更新日期:1993-07-09 00:00:00