Study of the morphological, electrophysiological and behavioral effects of unilateral kainic acid injection into the cat's substantia nigra.

abstract：:A new quantitative staining technique for the assay of protein in tissue sections using the dye Coomassie brilliant blue G 250 is discussed. This densitometric procedure uses commercially available hardware and software employed in the quantitation of receptor autoradiographs. Rather than assuming a homogeneous distri...

journal_title：Brain research

authors： Miller JA,Curella P,Zahniser NR

更新日期：1988-04-26 00:00:00

abstract：:Spectrally opponent processes of ON-type retinal ganglion cells and the blue preference behavior were identified by parallel physiological and behavioral experiments in Rana pipiens. Spectral opponency of retinal ON-units was measured by recording from optic nerve terminals in the anterior thalamus, while the retina w...

journal_title：Brain research

authors： Kicliter E,Kay CJ,Chino YM

更新日期：1981-04-06 00:00:00

abstract：:The primary objective of this study was to test the hypothesis that intravenous administration of autologous bone marrow cells could improve functional recovery after middle cerebral artery occlusion (MCAO) for 45 min in the rat and to determine specific time windows for efficacy. Mononuclear cells from autologous bon...

journal_title：Brain research

authors： Iihoshi S,Honmou O,Houkin K,Hashi K,Kocsis JD

更新日期：2004-05-08 00:00:00

abstract：:Glucose metabolism has been studied in the auditory cortex of human subjects with deafness of early onset, and compared to normal subjects with ears plugged. The metabolism in the auditory cortex and in the association auditory cortex was higher in deaf subjects than in normal subjects. This result is compared to simi...

journal_title：Brain research

authors： Catalán-Ahumada M,Deggouj N,De Volder A,Melin J,Michel C,Veraart C

更新日期：1993-10-01 00:00:00

abstract：:Sex differences in estrogen-induced progestin receptors have been described in specific regions of the rat brain. To determine if alpha 1-neurotransmission plays a role in the expression of the sex differences in progestin receptor induction, the effects of the alpha 1-antagonist, prazosin, on progestin binding in mic...

journal_title：Brain research

authors： Brown TJ,Naftolin F,MacLusky NJ

更新日期：1990-04-02 00:00:00

abstract：:These studies examined whether posttraining activation of alpha1-noradrenergic receptors in the nucleus tractus solitarius (NTS) influences neural processes that are involved in encoding information into memory. Different groups of male Sprague-Dawley rats were trained in two separate learning tasks. In experiment 1, ...

journal_title：Brain research

authors： Miyashita T,Williams CL

更新日期：2003-10-17 00:00:00

abstract：:Acute estradiol (E2) can potentiate the excitatory responses of hypothalamic ventromedial nucleus (VMN) neurons to neurotransmitters. To investigate the mechanism(s) underlying the potentiation, the whole-cell patch voltage clamp technique was used to study VMN neurons in hypothalamic slices prepared from female juven...

journal_title：Brain research

authors： Kow LM,Devidze N,Pataky S,Shibuya I,Pfaff DW

更新日期：2006-10-20 00:00:00

abstract：:Defeat stress in mice, a model of social stress, increases benzodiazepine receptor binding as measured by specific [3H]Ro15-1788 binding in vivo, but not by [3H]flunitrazepam binding in vitro. This increase occurs rapidly, by 20 min following exposure to stress, and resolves by 60 min. Increased benzodiazepine recepto...

journal_title：Brain research

authors： Miller LG,Thompson ML,Greenblatt DJ,Deutsch SI,Shader RI,Paul SM

更新日期：1987-06-30 00:00:00

abstract：:Male rats were treated with 10 mg/kg D-fenfluramine (DF) i.p., twice a day for 4 days. Five days later there was a strong reduction (70-100%) in the Bmax of [3H]citalopram binding and the Vmax of [3H]5-HT uptake in cortical and hippocampal synaptosomes; 2 months after the treatment these parameters were reduced by 40-...

journal_title：Brain research

authors： Gobbi M,Mancini L,Presti ML,Mennini T

更新日期：1996-08-19 00:00:00

abstract：:We have identified an inhibitory neuron (RPL4) in the right pleural ganglion of Aplysia, which produced hyperpolarization of the sensory and motor neurons involved in the tail withdrawal reflex. Activation of RPL4 significantly reduced the amplitude of excitatory postsynaptic potentials produced in tail motor neurons ...

journal_title：Brain research

authors： Buonomano DV,Cleary LJ,Byrne JH

更新日期：1992-04-10 00:00:00

abstract：:This study compared the responsivity of alpha 2-adrenoceptors to agonists in normotensive (WKY) and genetically hypertensive (SH) rats. Clonidine produced a greater degree of analgesia in SH as compared to WKY rats. This analgesia was antagonized by yohimbine. Neither naphazoline nor 4-hydroxy-clonidine produced analg...

journal_title：Brain research

authors： Marwaha J

更新日期：1984-06-25 00:00:00

abstract：:We used rabbit antisera against manganese (Mn)-superoxide dismutase for immunohistochemical studies of localization in the rat neostriatum. Immunostaining was intense in large-sized neurons and several medium-sized neurons, but it was moderate to weak in other cells. Double immunostaining with monoclonal antibody to c...

journal_title：Brain research

authors： Inagaki S,Suzuki K,Taniguchi N,Takagi H

更新日期：1991-05-17 00:00:00

abstract：:This work describes the presence of glucocorticoid binding sites in human temporal cortex obtained following partial lobectomy in two epileptic patients. Using [3H]dexamethasone as radioligand and cold cortisol or RU 28362 as competitor we found an apparent Kd of approximately 2.8 nM with a Bmax of approximately 34 fm...

journal_title：Brain research

authors： Sarrieau A,Dussaillant M,Sapolsky RM,Aitken DH,Olivier A,Lal S,Rostène WH,Quirion R,Meaney MJ

更新日期：1988-02-23 00:00:00

abstract：:We investigated the effect of ketogenic diet (KD) on clusterin accumulation in the kainic acid (KA)-induced seizure model. Two days after KA administration, strong clusterin-like immunoreactivity (IR) was detected in the hippocampus in the normal diet (ND)-fed mice. But in the KD-fed mice, few clusterin-like IR was de...

journal_title：Brain research

authors： Noh HS,Kim DW,Kang SS,Cho GJ,Choi WS

更新日期：2005-04-25 00:00:00

abstract：:Retinal lesions in pigeons produced a marked depletion of somata and neuropil staining for both calbindin-D28k and parvalbumin immunoreactivities in the contralateral optic tectum. Calbindin-like immunoreactivity reappeared in some tectal layers by 6 weeks postlesion, whereas paravalbumin-like immunoreactivity recover...

journal_title：Brain research

authors： Britto LR,Gobersztejn F,Karten HJ,Cox K

更新日期：1994-10-24 00:00:00

abstract：:An in vitro method has been developed to determine quantitatively the permeability of the perineurium to radiotracers at room temperature. The permeability to [14C]sucrose of the isolated perineurium of the sciatic nerve of the frog, Rana pipiens, was measured at rest length, when the perineurium was stretched and aft...

journal_title：Brain research

authors： Weerasuriya A,Rapoport SI,Taylor RE

更新日期：1979-09-21 00:00:00

abstract：:Results from the application of a procedure that allows simultaneous estimation of the rates of glucose transport from blood and of glucose phosphorylation in discrete regions of the brain are given for groups of rats displaying chemically induced motor disturbances. The procedure is based on sequential injections of ...

journal_title：Brain research

authors： Cremer JE,Ray DE,Sarna GS,Cunningham VJ

更新日期：1981-09-28 00:00:00

abstract：OBJECTIVE:To investigate the effect of salvinorin A (SA) on brain injury and neurologic function post-brain ischemia/reperfusion (I/R) using a rat forebrain ischemia model and further explore the effect of kappa opioid receptor (KOR) inhibition by SA on aquaporin-4 (AQP4) expression in the hippocampus, cortex and stria...

journal_title：Brain research

authors： Xin J,Zhang Y,He Z,Wang Z

更新日期：2016-04-15 00:00:00

abstract：:Infusion of carbachol into the lateral ventricles of rats at rates of 400 or 2000 ng/h for 6 h produced dose-related natriuresis, kaliuresis, and water drinking but no consumption of hypertonic NaCl solution. Electrolyte excretion and water intake were maximal during the first 2 h, and no further increases occurred af...

journal_title：Brain research

authors： Fitts DA,Thunhorst RL,Simpson JB

更新日期：1985-04-22 00:00:00

abstract：:Repeated intermittent administration of amphetamines acutely increases appetitive and consummatory aspects of motivated behaviors as well as general activity and exploratory behavior, including voluntary running wheel activity. Subsequently, if the drug is withdrawn, the frequency of these behaviors decreases, which i...

journal_title：Brain research

authors： Kitanaka N,Kitanaka J,Hall FS,Uhl GR,Watabe K,Kubo H,Takahashi H,Tatsuta T,Morita Y,Takemura M

更新日期：2012-01-06 00:00:00

abstract：:In rats kainic acid-induced seizures were accompanied by time-dependent cerebral cysteinyl-leukotriene (LT) and prostaglandin (PG) F2 alpha formation. Cysteinyl-LT were identified in the rat brain tissue extracts by their immunoreactive properties and their retention times upon reversed phase HPLC profiling. In perfus...

journal_title：Brain research

authors： Simmet T,Tippler B

更新日期：1990-05-07 00:00:00

abstract：:Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder associated with premutation alleles of the FMR1 gene that is characterized by progressive action tremor, gait ataxia, and cognitive decline. Recent studies of mitochondrial dysfunction in FXTAS have suggested that iron dysre...

journal_title：Brain research

authors： Ariza J,Steward C,Rueckert F,Widdison M,Coffman R,Afjei A,Noctor SC,Hagerman R,Hagerman P,Martínez-Cerdeño V

更新日期：2015-02-19 00:00:00

abstract：:Although astrocytes express gamma-aminobutyric acid subtype-A (GABAA) receptors in the mature brain, GABAA receptor expression in a cultivation state remains controversial. In this study, we investigated the alteration of astrocytic GABAA receptor expression in in vitro and in vivo studies to elucidate the relevance o...

journal_title：Brain research

authors： Tateishi N,Shimoda T,Manako J,Katsumata S,Shinagawa R,Ohno H

更新日期：2006-05-17 00:00:00

abstract：:The delay associated with cerebral processing time implies a lack of real-time representation of changes in the observed environment. To bridge this gap for motor actions in a dynamical environment, the brain uses predictions of the most plausible future reality based on previously provided information. To optimise th...

journal_title：Brain research

authors： Beudel M,Leenders KL,de Jong BM

更新日期：2016-12-01 00:00:00

abstract：:Quantitative and qualitative data are reported for single cerebral hemispheric neurons in a 3-dimensional hydrated collagen lattice (HCL) culture system. Individual neurons not in contact with other cells or cell processes, including synapses, rapidly displayed two morphologically distinct classes of processes that co...

journal_title：Brain research

authors： Coates PW

更新日期：1986-02-01 00:00:00

abstract：:A quantitative bioassay for nerve growth factor (NGF) has been previously described which employs PC13 rat pheochromocytoma cells. The basis of this assay is that rapid neurite regeneration by PC12 cells pretreated ('primed') with NGF for at least a week is quantitatively related to the amount of NGF present in the cu...

journal_title：Brain research

authors： Rukenstein A,Greene LA

更新日期：1983-03-14 00:00:00

abstract：:Nerve injury was produced by application of dry ice to the common peroneal nerve. After 20 weeks, muscle-spindle primary endings responded normally to stretch and the spindles were found to have a fully functional fusimotor innervation. ...

journal_title：Brain research

authors： Scott JJ

更新日期：1985-11-25 00:00:00

abstract：:Several neurologic illnesses in which excitotoxic mechanisms may play a role increase in prevalence with age. In the present study we examined the susceptibility of rats to quinolinic acid striatal lesions at 1, 4 and 20 months of age, and susceptibility to N-methyl-D-aspartate (NMDA) at 1 and 4 months of age. The ext...

journal_title：Brain research

authors： Finn SF,Hyman BT,Storey E,Miller JM,Beal MF

更新日期：1991-10-25 00:00:00

abstract：:GEC1 protein shares high identity with GABARAP (GABA(A) Receptor-Associated Protein), interacts with tubulin and GABA(A) receptors and is potentially involved in intracellular transport processes. Recently, using quantitative real time PCR, we have reported the gec1 mRNA expression in different rat brain areas. In the...

journal_title：Brain research

authors： Tolle F,Risold PY,Mansuy-Schlick V,Rossi E,Boyer-Guittaut M,Fraichard A,Jouvenot M

更新日期：2008-05-19 00:00:00

abstract：:In 22 squirrel monkeys (Saimiri sciureus) vocalization-eliciting electrodes were implanted into the amygdala and along the trajectory of the stria terminalis. Then, lesions were placed in the stria terminalis, its bed nucleus, the ventral amygdalofugal pathway and several di- and mesencephalic structures in order to f...

journal_title：Brain research

authors： Jürgens U

更新日期：1982-06-10 00:00:00