Supersensitivity of analgesic responses to alpha 2-adrenergic agonists in genetically hypertensive rats.

abstract：:Seventy-two hybridoma lines that produce monoclonal antibodies to molecules of a rat synaptosomal plasma membrane fraction (SPM) were generated. The topographical distribution of the antigens in the cerebellum and other areas of the brain was studied by light microscopy immunocytochemistry. Some of the antibodies reco...

journal_title：Brain research

authors： De Blas A,Kuljis RO,Cherwinski HM

更新日期：1984-11-26 00:00:00

abstract：:[d-Ala(2)-d-Leu(5)]-Enkephalin (DADLE) has shown promising results in protecting neurons from damages. However, the mechanism for this protection is still under investigation. The current study was carried out to test the hypothesis that DADLE may regulate cellular transcription in neurons. SH-SY5Y cells and primary c...

journal_title：Brain research

authors： Tian J,Gu Y,Sun K,Wang B,Chen J,Wang X,Su D

更新日期：2014-05-27 00:00:00

abstract：:The objective was to determine if corticopetal basal forebrain neurons could co-synthesize different transmitters. Histochemical labeling of a molecular marker of connectivity (wheat germ agglutinin lectin-bound horseradish peroxidase [HRP]; axonal uptake and retrograde transport from neocortex) and immunohistochemica...

journal_title：Brain research

authors： Fisher RS,Levine MS

更新日期：1989-07-03 00:00:00

abstract：:High-resolution positron emission tomography (microPET) allows for repeated observations of brain function in the same animal. In a previous study, using [(18)F] fluorodeoxyglucose (FDG) microPET, we demonstrated diminished glucose metabolism and subsequent recovery in the Neostriatum and thalamus ipsilateral to corti...

journal_title：Brain research

authors： Mir HM,Tatsukawa KJ,Carmichael ST,Chesselet MF,Kornblum HI

更新日期：2004-03-26 00:00:00

abstract：:Structural changes induced by high frequency (HF) stimulation on granule cells of the hippocampal dentate gyrus of rats with inborn high (HP) and low (LP) learning capacity was examined in this study. Two types of axodendritic synapses were processed morphometrically; the axonal bouton on dendritic shafts and those ma...

journal_title：Brain research

authors： Gómez RA,Pozzo Miller LD,Aoki A,Ramírez OA

更新日期：1990-12-24 00:00:00

abstract：:We quantified by microdensitometry the immunoreactivity (IR) to monoclonal antibodies (SP6, SP12, SP15 and SP18) against various synaptic proteins in the molecular layers of the dentate gyrus, CA4, CA3, CA1, subiculum and entorhinal cortex in Alzheimer's disease (AD), Lewy body variant of AD (LBV) and diffuse Lewy bod...

journal_title：Brain research

authors： Wakabayashi K,Honer WG,Masliah E

更新日期：1994-12-19 00:00:00

abstract：:S-allyl cysteine (SAC), a sulfur containing amino acid derived from garlic, has been reported to have antioxidant, anti-cancer, antihepatotoxic and neurotrophic activity. This study was designed to examine the pre-treatment effects of SAC on cognitive deficits and oxidative damage in the hippocampus of intracerebroven...

journal_title：Brain research

authors： Javed H,Khan MM,Khan A,Vaibhav K,Ahmad A,Khuwaja G,Ahmed ME,Raza SS,Ashafaq M,Tabassum R,Siddiqui MS,El-Agnaf OM,Safhi MM,Islam F

更新日期：2011-05-10 00:00:00

abstract：:Oligodendrocytes (OLs), the predominant cell type found in cerebral white matter, are essential for structural integrity and proper neural signaling. Very little is known concerning stroke-induced OL dysfunction. Our laboratory has shown that infusion of human umbilical cord blood (HUCB) cells protects striatal white ...

journal_title：Brain research

authors： Rowe DD,Leonardo CC,Hall AA,Shahaduzzaman MD,Collier LA,Willing AE,Pennypacker KR

更新日期：2010-12-17 00:00:00

abstract：:The subfornical organ of the brain has a role in the regulation of fluid balance in higher animals. In this study the effects of salt loading and water deprivation on specific proteins in this organ were investigated. For 4 days, 3 groups of rats were given an appropriate fluid diet (control, 2% NaCl and water deprive...

journal_title：Brain research

authors： Santer DM,Heydorn WE,Creed GJ,Klein DC,Jacobowitz DM

更新日期：1986-04-30 00:00:00

abstract：:We examined in the present study alterations in cerebral blood flow (CBF) and blood-brain barrier (BBB) permeability following intrastriatal transplantation of mouse bone marrow stromal cells (BMSCs) or saline infusion in adult Sprague-Dawley rats. Laser Doppler revealed that transplanted animals exhibited near normal...

journal_title：Brain research

authors： Borlongan CV,Lind JG,Dillon-Carter O,Yu G,Hadman M,Cheng C,Carroll J,Hess DC

更新日期：2004-05-29 00:00:00

abstract：:Oxidative stress has been suggested to play a key role in the neuropathogenesis of HIV infection. HIV proteins (gp120, Tat) and proinflammatory cytokines can trigger the production of reactive oxygen species (ROS), resulting in DNA and RNA lesions. Among all the lesions induced by ROS, one of the most abundant lesions...

journal_title：Brain research

authors： Zhang Y,Wang M,Li H,Zhang H,Shi Y,Wei F,Liu D,Liu K,Chen D

更新日期：2012-06-06 00:00:00

abstract：:The effect of the xanthine derivative propentofylline (HWA 285) on metabolic and functional recovery in rabbit spinal cord after 20 and 30 min ischemia and 4 days of reperfusion was investigated. Pre-treatment with 20 mg/kg significantly improved recovery of the energy state in the spinal cord, however, without signif...

journal_title：Brain research

authors： Danielisová V,Chavko M

更新日期：1992-09-11 00:00:00

abstract：:Blockade of gamma-aminobutyric acid (GABA) function in the posterior hypothalamus of rats elicits a pattern of physiological and behavioral arousal consisting of increases in heart rate, respiration and blood pressure as well as intense locomotor stimulation and a selective enhancement of avoidance responding. The pre...

journal_title：Brain research

authors： Shekhar A,Hingtgen JN,DiMicco JA

更新日期：1990-03-26 00:00:00

abstract：:Axonal projections of ganglion cells to the superior colliculus (SC) and to the nucleus of the optic tract (NOT) were re-examined physiologically in the cat's retina. Taking care to minimize current spreads around the stimulating electrodes placed in the NOT or the SC, we reached a conclusion that a substantial propor...

journal_title：Brain research

authors： Sawai H,Fukuda Y,Wakakuwa K

更新日期：1985-08-19 00:00:00

abstract：:The purpose of this study was to determine if motoneurons in the spinal ventral horn express the muscarinic m2 acetylcholine receptor. Motoneurons were retrogradely labelled in adult rats by intramuscular injection of Fluorogold and examined with confocal microscopy for evidence of immunoreactivity for the receptor. T...

journal_title：Brain research

authors： Welton J,Stewart W,Kerr R,Maxwell DJ

更新日期：1999-01-30 00:00:00

abstract：:Lesions of the insular cortex (IC) attenuate acquisition of conditioned taste aversions (CTAs). We have suggested that this impairment is the expected consequence of a failure of IC-lesioned (ICX) rats to recognize unfamiliar taste stimuli as novel. That is, ICX rats treat novel taste stimuli as if they are familiar a...

journal_title：Brain research

authors： Roman C,Lin JY,Reilly S

更新日期：2009-03-09 00:00:00

abstract：:Previous reports of the distribution of calbindin, a 28 kDa vitamin D-induced calcium-binding protein, in the mammalian peripheral vestibular system postulated that this protein was involved in the calcium-dependent mechanisms occurring in the hair cells and ganglion cells. In this study, we examined the possibility o...

journal_title：Brain research

authors： Dechesne CJ,Thomasset M

更新日期：1988-05-16 00:00:00

abstract：:Even though animal and human studies show alterations in dopamine transporter (DAT) sites after alcohol withdrawal, the role of DAT in influencing either alcoholic or depressive behavior has not been examined extensively. Given that the Wistar-Kyoto (WKY) rat is a putative animal model of depressive behavior, the pres...

journal_title：Brain research

authors： Jiao X,Paré WP,Tejani-Butt SM

更新日期：2006-02-16 00:00:00

abstract：:Tinnitus, the perception of a phantom sound, is a common consequence of damage to the auditory periphery. A major goal of tinnitus research is to find the loci of the neural changes that underlie the disorder. Crucial to this endeavor has been the development of an animal behavioral model of tinnitus, so that neural c...

journal_title：Brain research

authors： Baizer JS,Manohar S,Paolone NA,Weinstock N,Salvi RJ

更新日期：2012-11-16 00:00:00

abstract：:Previous studies have shown that muscarinic cholinergic agonists bind to 3 distinct receptor sites in brain, each being distinguished by their affinity for the agonists. Antagonists, on the other hand, bind to these sites with the same high affinity. The relative concentrations of the two high and the low affinity ago...

journal_title：Brain research

authors： Wamsley JK,Zarbin MA,Birdsall NJ,Kuhar MJ

更新日期：1980-10-27 00:00:00

abstract：:The projections of serotonin-containing neurons of the midbrain raphe nuclei (nucleus raphe dorsalis, nucleus centralis superior) are studied by analysis of axonal transport of labeled amino acids. These results are correlated with regional alterations of serotonin content following midbrain raphe lesions which produc...

journal_title：Brain research

authors： Halaris AE,Jones BE,Moore RY

更新日期：1976-05-14 00:00:00

abstract：:To investigate whether tactile spatial attention is modulated by perceptual load, behavioural and electrophysiological measures were recorded during two spatial cuing tasks in which the difficulty of the target/non-target discrimination was varied (High and Low load tasks). Moreover, to study whether attentional modul...

journal_title：Brain research

authors： Gherri E,Berreby F

更新日期：2017-10-15 00:00:00

abstract：:gamma-Aminobutyric acid (GABA) synthesis in the brain is mediated by two major isoforms of glutamic acid decarboxylase, GAD(65) and GAD(67). The contribution of these isoforms to GABA synthesis flux (V(GAD)) is not known quantitatively. In the present study we compared V(GAD) in cortex of control and vigabatrin-treate...

journal_title：Brain research

authors： Mason GF,Martin DL,Martin SB,Manor D,Sibson NR,Patel A,Rothman DL,Behar KL

更新日期：2001-09-28 00:00:00

abstract：:The distribution of immunocytochemically localized subunits that comprise ionotropic non-NMDA excitatory amino acid receptors was examined in human frontal, parietal and temporal association neocortex. AMPA/kainate receptor subunits were identified using a monoclonal antibody (3A11) that recognizes an epitope common t...

journal_title：Brain research

authors： Vickers JC,Huntley GW,Hof PR,Bederson J,DeFelipe J,Morrison JH

更新日期：1995-02-06 00:00:00

abstract：:The alpha7 nicotinic acetylcholine receptor (nAChR) plays an important role in cognitive processes and has generated recent interest as a potential drug target for treating neurodegenerative disorders such as Alzheimer's disease (AD). The property of Ca(2+) permeation associated with alpha7 nAChR agonism may lead to C...

journal_title：Brain research

authors： Bitner RS,Nikkel AL,Markosyan S,Otte S,Puttfarcken P,Gopalakrishnan M

更新日期：2009-04-10 00:00:00

abstract：:Saccadic adaptation is the progressive correction of systematic saccade targeting errors. When a saccade to a particular target is adapted, saccades within a spatial window around the target, the adaptation field, are affected as a function of their distance from the adapted target. Furthermore, previous studies sugge...

journal_title：Brain research

authors： Collins T,Doré-Mazars K,Lappe M

更新日期：2007-10-03 00:00:00

abstract：:Photoreceptor outer segments are continually renewed from base to tip and consequently the membrane at the tip is older than at the base. In parallel with this, there are differences in light responsiveness, and it has been proposed that these may be due to the aforementioned differences in age. We have tested this pr...

journal_title：Brain research

authors： Leibovic KN,Bandarchi J

更新日期：1997-03-07 00:00:00

abstract：:The activity of choline kinase (CK) was examined in the rat superior cervical ganglion (SCG) during development and following postganglionic axotomy. The highest specific enzyme activity (nmol phosphorylcholine/mg protein/h) 52 +/- 8, is observed 5 d before birth, then it rapidly decreases by about 50%, reaching at th...

journal_title：Brain research

authors： Gilad GM,Gilad VH

更新日期：1981-09-14 00:00:00

abstract：:Responses of subthalamic neurons (STN) to the iontophoretic application of glutamate (Glu), acetylcholine (ACh) and GABA were studied in rats 2 or 3 weeks following bilateral decortication, and were compared to those obtained in normal animals. All the cells recorded in lesioned rats showed a decrease in their spontan...

journal_title：Brain research

authors： Rouzaire-Dubois B,Scarnati E

更新日期：1987-02-17 00:00:00

abstract：:It is well documented that VMAT2 protects nigrostriatal DA neurons against MPP(+) by sequestering it inside vesicles away from its mitochondrial site of neurotoxic action. However, the implication of the VMAT2 in the mechanism of action exerted by 6-OHDA has received little attention. Therefore, the aim of the present...

journal_title：Brain research

authors： Cleren C,Naudin B,Costentin J

更新日期：2003-11-07 00:00:00