Increase in glutamate sensitivity of subthalamic nucleus neurons following bilateral decortication: a microiontophoretic study in the rat.

abstract：:Glutamate induced responses in the surface membrane of Xenopus oocyte by injection with mRNA from crustacea and insect muscle. Glutamate (10(-5) to 10(-4) M) elicited smooth current responses which resembled those induced by kainate. This smooth current reversed direction at about 0 mV and was blocked by a spider toxi...

journal_title：Brain research

authors： Saito M,Ohsako S,Deguchi T,Kawai N

更新日期：1987-12-01 00:00:00

abstract：:Our previous studies have shown that there is a lower cGMP concentration in the aged brain as well as an alteration in the activity of cGMP-hydrolyzing phosphodiesterases (PDEs) and nitric oxide synthase (NOS). The aim of this study was to investigate the effect of specific inhibitors of selected PDEs on object recogn...

journal_title：Brain research

authors： Domek-Łopacińska K,Strosznajder JB

更新日期：2008-06-24 00:00:00

abstract：:This study describes the localization of [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3, synthetic peptide leptin mimetics, in the hypothalamus of Swiss Webster and C57BL/6J wild-type mice, leptin-deficient ob/ob mice, and leptin-resistant diet-induced obese (DIO) mice. The mice were given [D-Leu-4]-OB3 or MA-[D-Leu-4]-OB3 in 0.3...

journal_title：Brain research

authors： Anderson BM,Jacobson L,Novakovic ZM,Grasso P

更新日期：2017-06-01 00:00:00

abstract：:Results of previous studies suggested that incertohypothalamic dopamine (IHDA) neurons located in the medial zona incerta (MZI) project to the central nucleus of the amygdala (cAMY), horizontal diagonal band of Broca (HDB), and paraventricular nucleus (PVN). The overall goal of the present study was to determine the r...

journal_title：Brain research

authors： Cheung S,Ballew JR,Moore KE,Lookingland KJ

更新日期：1998-10-19 00:00:00

abstract：:Stanniocalcin (STC-1), a 50 kDa glycoprotein hormone that regulates calcium/phosphate homeostasis in bony fish and mammals, has been shown to be expressed in central neurons and choroid plexus, and to exert a protective effect against hypercalcemic and hypoxic damage to neurons. Circumventricular organs are known to f...

journal_title：Brain research

authors： Ratkovic S,Wagner GF,Ciriello J

更新日期：2008-07-07 00:00:00

abstract：:Amyloid precursor protein (APP) is a ubiquitously expressed membrane spanning glycoprotein which is endoproteolytically processed to Abeta, a 39-43 amino acid peptide that is the main component of senile plaques in Alzheimer Disease (AD). APP is a member of a highly conserved gene family, including Amyloid Precursor-L...

journal_title：Brain research

authors： McNamara MJ,Ruff CT,Wasco W,Tanzi RE,Thinakaran G,Hyman BT

更新日期：1998-08-31 00:00:00

abstract：:A direct projection from rat mesencephalic trigeminal nucleus (Vme) neurons to the hypoglossal nucleus (XII) motoneurons was studied using a double labeling method of anterogradely biotinylated dextran amine (BDA) tracing combined with retrogradely horseradish peroxidase (HRP) transport at both light and electron micr...

journal_title：Brain research

authors： Zhang J,Luo P,Pendlebury WW

更新日期：2001-10-26 00:00:00

abstract：:Glucocorticoids bind with high affinity to intracellular receptors located in high density within discrete regions of the rodent and primate brain. The binding of [3H]corticosterone was compared in the brains of male vs female rats. The number and affinity of cytosol receptors in the hippocampus and hypothalamus were ...

journal_title：Brain research

authors： Turner BB,Weaver DA

更新日期：1985-09-16 00:00:00

abstract：:The effects of intracerebroventricular administration of 6-hydroxydopamine (6-OHDA) and 5,7-dihydroxytryptamine (5,7-DHT) on sodium-sensitive [3H]mazindol binding were investigated in the rat hypothalamus and corpus striatum. In the hypothalamus, specific [3H]mazindol binding was inhibited by low concentrations of sod...

journal_title：Brain research

authors： Angel I,Janowsky A,Paul SM

更新日期：1989-12-04 00:00:00

abstract：:Chronic intermittent hypoxia (CIH) may cause sustained systemic hypertension by increasing sympathetic neural discharge (SND). We hypothesized that CIH alters brainstem circuits modulating SND. After 30 days of CIH exposure in rats, increased c-fos labeling was seen in the nucleus of the solitary tract and ventrolater...

journal_title：Brain research

authors： Greenberg HE,Sica AL,Scharf SM,Ruggiero DA

更新日期：1999-01-23 00:00:00

abstract：:Electrophysiological methods were used to investigate the effects of trigeminal nerve stimulation or transection on responses of single gustatory neurons in the nucleus of the solitary tract (NTS) to tastants (NaCl, sucrose, citric acid, monosodium glutamate) in pentobarbital-anesthetized rats. Unilateral transection ...

journal_title：Brain research

authors： Boucher Y,Simons CT,Faurion A,Azérad J,Carstens E

更新日期：2003-05-30 00:00:00

abstract：:In kittens, but not in adult cats, depriving one eye of pattern vision by suturing the lids shut (monocular deprivation or MD) for one week reduces the proportion of binocular units in the visual cortex. A sensitivity of cortical units in adult cats to MD can be produced by infusing exogenous monoamines into the visua...

journal_title：Brain research

authors： McCall MA,Tieman DG,Hirsch HV

更新日期：1982-11-04 00:00:00

abstract：:The hypothesis that early social isolation results in long-term alterations in dopamine receptor sensitivity was tested using older adult rhesus monkeys. Isolated and control monkeys were challenged with apomorphine (0.1 and 0.3 mg/kg), and the drug effects on spontaneous blink rate, stereotyped behavior, and self-inj...

journal_title：Brain research

authors： Lewis MH,Gluck JP,Beauchamp AJ,Keresztury MF,Mailman RB

更新日期：1990-04-09 00:00:00

abstract：:Spontaneous hippocampal EEG activity and evoked field potentials were investigated in intact rats and in animals with fetal hippocampal grafts. Pieces of hippocampal grafts, derived from 15- to 16-day-old fetuses, were used to prepare cell suspensions and grafted directly into the intact hippocampus. Control animals r...

journal_title：Brain research

authors： Buzsáki G,Masliah E,Chen LS,Horváth Z,Terry R,Gage FH

更新日期：1991-07-19 00:00:00

abstract：:We previously showed indirectly that the increase in diacylglycerol (DAG) levels caused by exposing differentiating PC12 cells to nerve growth factor (NGF) must derive mainly from de novo synthesis and, to a lesser and transient extent, from the hydrolysis of [3H]phosphatidylinositol (PI). To explore further the bioch...

journal_title：Brain research

authors： Li J,Wurtman RJ

更新日期：1999-02-13 00:00:00

abstract：:Neurotensin is a putative peptide neurotransmitter in the mammalian brain. The light microscopic localization of the neurotensin receptor has been carried out by the autoradiographic localization of [3H]neurotensin binding sites in slide-mounted tissue sections. Large variations in receptor distribution were found, ev...

journal_title：Brain research

authors： Young WS 3rd,Kuhar MJ

更新日期：1981-02-16 00:00:00

abstract：:The mesocorticolimbic circuitry has been implicated in the pathophysiology of several neuropsychiatric syndromes like chronic pain and addiction. The aim of this study was to evaluate the effects of dizocilpine (MK-801), a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, on sensorimotor behaviors and t...

journal_title：Brain research

authors： Al-Amin HA,Saadé NE,Khani M,Atweh S,Jaber M

更新日期：2003-08-15 00:00:00

abstract：:The fate of dissociated neurons from 8-day chick embryo ciliary ganglia, cultured in serum-containing media on polyornithine substrata, is influenced by two different macromolecular factors. The neurons will die within 24 h in the absence of CNTF, the eye-derived ciliary neuronotrophic factor. Even when supported by C...

journal_title：Brain research

authors： Adler R,Manthorpe M,Varon S

更新日期：1982-12-01 00:00:00

abstract：:Two separate in vitro assays were used to examine the biosynthesis of the broad spectrum excitatory amino acid receptor antagonist kynurenic acid (KYNA) during the life span of the adult rat. Assessment of KYNA's anabolic enzyme kynurenine aminotransferase revealed steady increases between 3 and 24 months of age in al...

journal_title：Brain research

authors： Gramsbergen JB,Schmidt W,Turski WA,Schwarcz R

更新日期：1992-08-14 00:00:00

abstract：:The effects of the putative dopaminergic antagonist, haloperidol (0.01-10 mg/kg, i.v.), on cerebral glucose utilization in 43 anatomically discrete regions of the rat brain have been examined by the quantitative autoradiographic 2-deoxyglucose technique. Dose-dependent reductions in glucose utilization were observed i...

journal_title：Brain research

authors： McCulloch J,Savaki HE,Sokoloff L

更新日期：1982-07-08 00:00:00

abstract：:Met-enkephalin-like immunoreactive material (ME-LI) in the neurointermediate lobe of rat pituitary was dramatically altered by the long-term administration of drugs altering dopamine receptor activity. Treatment with the dopamine receptor antagonist haloperidol resulted in significant increases of ME-LI and treatment ...

journal_title：Brain research

authors： George SR,Kertesz M

更新日期：1985-05-13 00:00:00

abstract：:Hippocampal slices were taken from 7-day-old rats and maintained in vitro for 1-3 weeks. The organization of intrahippocampal connections in these explants was studied by placing onto the tissue small crystals of horseradish peroxidase (HRP) soaked with the detergent Nonidet. Antero- and retrograde transport of HRP wa...

journal_title：Brain research

authors： Keller F,Lipp HP,Waser PG

更新日期：1986-08-13 00:00:00

abstract：:Contradictory results have been reported with regard to the effects of various models of hepatic encephalopathy on the blood-brain barrier (BBB) permeability, which may be due partly to the use of brain concentrations of BBB markers without attention to their peripheral pharmacokinetics. The purpose of the current stu...

journal_title：Brain research

authors： Shaik IH,Miah MK,Bickel U,Mehvar R

更新日期：2013-09-19 00:00:00

abstract：:In the present study, we investigated the co-localization pattern of the delta subunit with other subunits of GABA(A) receptors in the rat brain using immunoprecipitation and Western blotting techniques. Furthermore, we investigated whether low concentrations of ethanol affect the delta-subunit-containing GABA(A) rece...

journal_title：Brain research

authors： Mehta AK,Marutha Ravindran CR,Ticku MK

更新日期：2007-08-24 00:00:00

abstract：:Postsynaptic potentials were evoked in neostriatal neurons by stimulation of the ipsilateral and contralateral medial agranular frontal cortical field (AGm) in the rat. This cortical region is known to project bilaterally to the dorsal lateral head of the caudate-putamen of rats. Ipsilateral stimulation of AGm should ...

journal_title：Brain research

authors： Wilson CJ

更新日期：1986-03-05 00:00:00

abstract：:The effects of noxious and non-noxious limb stimulations on the second exteroceptive suppression of voluntary temporalis muscle activity (ES2) were studied in healthy human volunteers. Duration of temporalis ES2 was measured on averaged rectified responses obtained after stimulating the labial commissure at an intensi...

journal_title：Brain research

authors： Schoenen J,Wang W,Gerard P

更新日期：1994-09-19 00:00:00

abstract：:Occipital cortex of 19-day-old fetal rats was dissociated and cultured in vitro for 2-5 weeks in horse serum supplemented Eagle's MEM. The outgrowing neurons rapidly formed a dense network which started to degenerate after 3 weeks in vitro. By means of electron microscopy the numerical development of 6 different categ...

journal_title：Brain research

authors： Romijn HJ,Mud MT,Habets AM,Wolters PS

更新日期：1981-07-01 00:00:00

abstract：:We used two approaches to test the possibility that changes in presynaptic calcium currents might be responsible for the long-term potentiation (LTP) effect induced by high-frequency stimulation in area CA1 of hippocampal slices. In a first series of experiments, we compared the effect of LTP induction on paired-pulse...

journal_title：Brain research

authors： Muller D,Lynch G

更新日期：1989-02-13 00:00:00

abstract：:Thalamocortical connections were studied after injections of retrograde tracers were made into rostral or caudal parts of cortical area Fr2 in adult rats. The data reveal that both rostral Fr2 (rFr2) and caudal Fr2 (cFr2) receive input from the centrolateral, central medial, interanteromedial, mediodorsal, paracentral...

journal_title：Brain research

authors： Hicks RR,Huerta MF

更新日期：1991-12-24 00:00:00

abstract：:Astrocytes cultured from the brains of neonatal rat pups acquire at least two specializations of intramembrane particle distribution: 'assemblies' and gap junctions. The number and appearance of assemblies in the cultured astrocytes is not markedly influenced by the presence or absence of a collagen substrate, and the...

journal_title：Brain research

authors： Landis DM,Weinstein LA

更新日期：1983-10-03 00:00:00