Abstract：
:The hypothesis that early social isolation results in long-term alterations in dopamine receptor sensitivity was tested using older adult rhesus monkeys. Isolated and control monkeys were challenged with apomorphine (0.1 and 0.3 mg/kg), and the drug effects on spontaneous blink rate, stereotyped behavior, and self-injurious behavior were quantified using observational measures. Monoamine metabolites were quantified from cisternal CSF by HPLC-EC, prior to pharmacological challenge. Isolated and control monkeys did not differ in CSF concentrations of HVA, 5-HIAA, or MHPG. At the higher dose, apomorphine significantly increased the rate of blinking, the occurrence of whole-body stereotypies, and the intensity of stereotyped behavior (as measured by observer ratings) in isolated monkeys. The frequency of occurrence of self-injurious behavior was too low to allow for meaningful comparisons. These significant differences in response to apomorphine challenge support the hypothesis that long-term or permanent alterations in dopamine receptor sensitivity, as assessed by drug challenge, are a consequence of early social deprivation.
journal_name
Brain Resjournal_title
Brain researchauthors
Lewis MH,Gluck JP,Beauchamp AJ,Keresztury MF,Mailman RBdoi
10.1016/0006-8993(90)91089-ysubject
Has Abstractpub_date
1990-04-09 00:00:00pages
67-73issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(90)91089-Yjournal_volume
513pub_type
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