Abstract:
:Spontaneous hippocampal EEG activity and evoked field potentials were investigated in intact rats and in animals with fetal hippocampal grafts. Pieces of hippocampal grafts, derived from 15- to 16-day-old fetuses, were used to prepare cell suspensions and grafted directly into the intact hippocampus. Control animals received suspension grafts of the cerebellum derived from fetuses of identical age. Host hippocampal electrical patterns were monitored with chronic single electrodes or with a 16-microelectrode probe from 7 to 10 months after grafting. In contrast to previously reported high survival rates of fetal grafts in studies with damage to the host brain prior to grafting, survival of both hippocampal (60%) and cerebellar grafts (20%) was very poor in the intact hippocampus. In animals with cerebellar transplants or without surviving grafted neurons the electrical activity of the host hippocampus was indistinguishable from normal controls. In rats with hippocampal grafts short duration, large amplitude EEG spikes (up to 10 mV) were recorded, predominantly during immobility. When the EEG spikes (putative interictal spikes) were of large amplitude and contained population spikes, test evoked responses delivered to the perforant path were suppressed after the spontaneous events. In contrast, evoked responses were facilitated by interictal spikes without population spikes. The threshold of electrically induced afterdischarges did not differ significantly between groups of intact rats and animals with or without hippocampal grafts. However, in three rats with hippocampal grafts the evoked afterdischarges were associated with behavioral seizures. In two of these rats spontaneously occurring seizures were also observed. Synaptophysin-immunoreactivity demonstrated growth of the host mossy fibers into the graft.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Brain Resjournal_title
Brain researchauthors
Buzsáki G,Masliah E,Chen LS,Horváth Z,Terry R,Gage FHdoi
10.1016/0006-8993(91)90168-usubject
Has Abstractpub_date
1991-07-19 00:00:00pages
30-7issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(91)90168-Ujournal_volume
554pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Considerable evidence indicates an enhanced sympathetic innervation of muscular resistance arteries in the spontaneously hypertensive rat (SHR) compared with its normotensive Wistar-Kyoto (WKY) control. Since nerve growth factor (NGF) is known to affect the growth of sympathetic nerves, we have utilized a sensitive tw...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91012-h
更新日期:1993-06-18 00:00:00
abstract::We are interested in studying the co-localization of NMDA glutamate receptor subunits (NR1, NR2A/B) and AMPA glutamate receptor subunits (GluR1, GluR2, GluR2/3 and GluR4) in individual neurons of the rat vestibular nuclei. Immunoreactivity for NR1, NR2A/B, GluR1, GluR2, GluR2/3 and GluR4 was found in the somata and de...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02913-9
更新日期:2000-11-24 00:00:00
abstract::The parafascicular thalamic nucleus (nPf) is a critical relay in the ascending system that mediates motor control in the central nervous system (CNS). Yet, little is known about whether or not the nPf is involved in the development of morphine dependence and withdrawal. In the present study, kainic acid was used to ch...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.02.084
更新日期:2009-05-19 00:00:00
abstract::Vasopressin generates a voltage-gated, sodium-dependent current in facial motoneurons in brainstem slices. Reducing the extracellular calcium concentration from 2 to 0.01 mM caused a 30 to 120% increase in the amplitude of this current. Lowering extracellular magnesium also enhanced it, but less efficiently. In the ph...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90097-7
更新日期:1993-10-08 00:00:00
abstract::Delta-9-tetrahydrocannabinol (Delta(9)-THC), the main psychoactive component of marijuana, is known to dysregulate various immune responses. Cannabinoid (CB)-1 and -2 receptors are expressed mainly on cells of the central nervous system (CNS) and the immune system. The CNS is the primary target of cannabinoids and ast...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.10.062
更新日期:2008-01-29 00:00:00
abstract::Whole cell and single channel Ca2+ currents were compared for hippocampal neurons of normal and ethanol-tolerant long-sleep and short-sleep mice. The properties of these currents were equivalent for normal LS and SS mice. In contrast, the peak amplitude of the whole cell Ca2+ current increased significantly for neuron...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90044-n
更新日期:1993-07-02 00:00:00
abstract::The patch clamp technique has been used to study ion channel activity in the apical (ventricular) membrane of epithelial cells from the rat choroid plexus. Two different classes of Cl(-)-selective channel were identified. A low conductance (26 pS) channel which was the predominant feature in cell-attached and inside-o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90988-l
更新日期:1992-09-18 00:00:00
abstract::To investigate whether tactile spatial attention is modulated by perceptual load, behavioural and electrophysiological measures were recorded during two spatial cuing tasks in which the difficulty of the target/non-target discrimination was varied (High and Low load tasks). Moreover, to study whether attentional modul...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.08.007
更新日期:2017-10-15 00:00:00
abstract::Since hypertension and/or hyperglycemia are risk factors for stroke, we examined whether the putative neuroprotectant, nicotinamide (NAm), could protect spontaneously hypertensive rats (SHR) or diabetic Fischer 344 rats against focal cerebral ischemia using a model of permanent middle cerebral artery occlusion (MCAo)....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02263-1
更新日期:2002-03-22 00:00:00
abstract::Neonatal MK-801 treatment from postnatal day 8-19 leads to long-term effects on brain function, suggesting that exposure to this drug leads to the development of a brain with immature network properties. One aspect of this hypothesis, that the NMDA receptors preserve their immature state after the treatment, has been ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91152-5
更新日期:1994-11-28 00:00:00
abstract::A systematic clinical neuroscience protocol is described for the use to examine the trigemino-cardiac reflex (TCR) response in humans. Target neurosurgical conditions are operations that require manipulations around the peripheral and central part of the trigeminal nerve and its branches, e.g. the cerebellopontine ang...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.08.060
更新日期:2007-05-29 00:00:00
abstract::To investigate the reversibility of neuronal functions during deep and mild hypothermia, we have examined changes in membrane properties of pyramidal neurons of the CA3 region of hippocampal slices during cooling and rewarming (8 approximately 37 degrees C) of the perfusion medium. Hypothermia reduced the excitatory p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)03285-6
更新日期:2001-03-02 00:00:00
abstract::The benzomorphan sigma ligands, (+)-N-allylnormetazocine (NANM) and (+)-pentazocine, but not (+)-cyclazocine, stereospecifically stimulated dopamine synthesis in minces of rat corpus striatum by 15-23% over basal values at 0.1-1.0 microM. The effect of (+)-NANM and (+)-pentazocine was blocked by the reported sigma ant...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90159-s
更新日期:1991-08-23 00:00:00
abstract::In pentobarbitone-anesthetized cats breathing spontaneously, we studied whether excision of one petrosal ganglion would modify the reflex efficacy of the remaining carotid and aortic chemoafferences in ventilatory control. Resting ventilation was not affected shortly after the ganglionectomy, but decreased sensitiviti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91495-3
更新日期:1990-07-23 00:00:00
abstract:OBJECTIVES:Neuroprotective benefits of ethanol (EtOH) and normobaric oxygenation (NBO) were previously demonstrated in transient and permanent ischemic stroke. Here we sought to identify whether the enhanced lactic acidosis and increased expression of monocarboxylate transporters (MCTs) observed after stroke might be a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.01.040
更新日期:2015-04-07 00:00:00
abstract::This study examined the spatial organization of corticotropin-releasing factor (CRF) immunopositive climbing fibers in the mouse cerebellum by whole mount immunohistochemistry. A striking pattern of parasagittal stripes of CRF staining was revealed. Cryosections of whole mount CRF stained cerebellum showed that anti-C...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.05.029
更新日期:2008-07-30 00:00:00
abstract::Ciliary ganglion neurons from chick embryo were grown in cell culture following enzymatic and mechanical dissociation. The culture conditions necessary for long-term (greater than 21 days) survival of the isolated neurons were investigated. Neurons could be cultured with and without non-neural cells by adjusting the c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90127-4
更新日期:1980-02-03 00:00:00
abstract::The pars externa (PE) system of the anterior olfactory nucleus (AON) in a primate, Callithrix jacchus, was defined by its architecture and by its connection patterns with the main olfactory bulb (MOB) as revealed by tracing techniques. Focal, unilateral injections of wheat germ agglutinin-conjugated horseradish peroxi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90071-6
更新日期:1988-08-02 00:00:00
abstract::The use of the fluorescence retrograde double-labeling method has revealed that striatal neurons projecting to the globus pallidus in the squirrel monkey are mainly confined to the putamen whereas those projecting to the substantia nigra occur mostly in the caudate nucleus. Only about 10% of the striatal neurons were ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91224-1
更新日期:1984-06-15 00:00:00
abstract::Efflux of choline from the rat cerebral cortex in vivo was investigated using the cup technique. After removal of the dura mater, the cup was placed on the cortex. Transmission and scanning electron microscopy revealed that the cortex was separated from the cup solution (100-300 microliter) by basal lamina, pia mater,...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91007-8
更新日期:1985-10-21 00:00:00
abstract::In primary neuron cultures obtained from ventral mesencephalon of mouse fetuses, approximately 10-30% of the neurons were dopaminergic, as demonstrated by a rapid glyoxylic acid histofluorescence procedure, and another 10-30% were GABAergic as demonstrated by autoradiography. Resting membrane potentials averaged -58 m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(88)90024-7
更新日期:1988-04-01 00:00:00
abstract::We have shown earlier that nicotinic agonists induce the release of noradrenaline from chick sympathetic neurons in culture in two ways: (a) by activating the postsynaptic nicotinic receptors on nerve cell bodies, giving rise to spreading electrical activity and opening of voltage operated calcium channels in neuronal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)00876-1
更新日期:1996-11-18 00:00:00
abstract::Large neuronal perikarya isolated in bulk fractions from adult bovine ventral spinal cord and examined by electron microscopy have discontinuities in their plasma membrane. A systematic investigation of the possible causes of the membrane defects indicates that the act of mechanical dissociation of the neurons from th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90108-7
更新日期:1978-12-22 00:00:00
abstract::Kernicterus is a bilirubin-induced encephalopathy in newborn. Its spectrum ranges from subtle extrapyramidal to acute encephalopathy and chronic posticteric sequelae. Current treatment of this serious problem is far from optimal. Taurine has been documented to have protective effects on neuronal cells against ischemia...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.01.036
更新日期:2010-03-12 00:00:00
abstract::The independent and combined effects of Ca2+, Mg2+, Zn2+, Al3+ and Li+ on [3H]MK-801 binding in human cerebral cortical membranes were studied to further characterize the modulatory effects of metal ions on the N-methyl-D-aspartate (NMDA) receptor-ionophore. Glycine, in the presence of glutamate, significantly intensi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91290-0
更新日期:1989-05-01 00:00:00
abstract::Freezing and escape responses induced by gradual increases in the intensity of the electrical current applied to dorsal regions of the periaqueductal gray (dPAG) cause a distinct pattern of Fos distribution in the brain. From these studies, it has been suggested that a pathway involving the dPAG itself, dorsomedial hy...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.10.044
更新日期:2005-01-21 00:00:00
abstract::The distribution of calretinin containing neurons examined by in situ hybridization mapping was compared with that obtained by immunocytochemistry in the brain of octopus. Results revealed a close correspondence between the two types of investigations. Western blot analysis disclosed a 29 kDa protein immunostained wit...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.11.056
更新日期:2007-02-09 00:00:00
abstract::Traumatic brain injury (TBI) in humans typically produces neurological suppression and a longer lasting impairment of memory clinically defined as post-traumatic amnesia. An animal model that reliably reproduces the physiological changes associated with TBI was used to assess the memory deficits following brain injury...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91014-j
更新日期:1993-06-18 00:00:00
abstract::Nuclear factor κB (NFκB) signaling plays ubiquitous roles in inflammation, immune response and neurogenesis. G protein-coupled receptor kinase 5 (GRK5) can protect neurons from degeneration. GRK5 also mediates tumor necrosis factor-α (TNFα)-induced NFκB signaling through the phosphorylation of IκBα. Here, we show that...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.02.041
更新日期:2015-05-22 00:00:00
abstract::Functionally activated sites usually have multiple specificities where coactivation is induced by inputs with different informational content. Using typical voxel-based functional mapping (univariate analysis), it is possible to show the presence of coactivation; however, it is not possible to distinguish whether coac...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.10.020
更新日期:2010-12-17 00:00:00