Abstract：
:The benzomorphan sigma ligands, (+)-N-allylnormetazocine (NANM) and (+)-pentazocine, but not (+)-cyclazocine, stereospecifically stimulated dopamine synthesis in minces of rat corpus striatum by 15-23% over basal values at 0.1-1.0 microM. The effect of (+)-NANM and (+)-pentazocine was blocked by the reported sigma antagonist, BMY-14802 but not by the opiate antagonist naloxone. These results suggest that these (+)-benzomorphans may act as agonists at putative sigma heteroreceptors on striatal nerve terminals, or through an indirect mechanism, to modulate dopamine synthesis.
journal_name
Brain Resjournal_title
Brain researchauthors
Booth RG,Baldessarini RJdoi
10.1016/0006-8993(91)90159-ssubject
Has Abstractpub_date
1991-08-23 00:00:00pages
349-52issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(91)90159-Sjournal_volume
557pub_type
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