Abstract：
:The independent and combined effects of Ca2+, Mg2+, Zn2+, Al3+ and Li+ on [3H]MK-801 binding in human cerebral cortical membranes were studied to further characterize the modulatory effects of metal ions on the N-methyl-D-aspartate (NMDA) receptor-ionophore. Glycine, in the presence of glutamate, significantly intensified the Mg2+ inhibition of [3H]MK-801 binding whereas it masked the Ca2+ enhancement and slightly diminished the Zn2+ inhibition. Both Ca2+ and Mg2+ reduced the Zn2+ inhibitory potency. Aluminum demonstrated a potent, relatively glycine-insensitive inhibition of [3H]MK-801 binding as an amorphous Al(OH)3 polymer rather than as the free ion. Cationic modulation of the NMDA receptor-ionophore appears to be regulated at multiple sites which have significant allosteric interactions.
journal_name
Brain Resjournal_title
Brain researchauthors
Hubbard CM,Redpath GT,Macdonald TL,VandenBerg SRdoi
10.1016/0006-8993(89)91290-0subject
Has Abstractpub_date
1989-05-01 00:00:00pages
170-4issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(89)91290-0journal_volume
486pub_type
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