Abstract：
:One of the fundamental tasks of neurobiology is to understand how the precision and specificity of the adult nervous system is achieved during development. This paper reviews the progress that has been made toward this end in studies of the developing mammalian cerebral cortex. Particular attention is focused on the problem of how cortical neurons make decisions during development: the correlation between a neuron's 'birthday' and its final laminar destination and projection patterns has raised the possibility that young neurons may be committed to their adult fates very early on in development, perhaps prior to migration. Indeed, several lines of evidence reviewed here suggest that at least some of the decisions made by cortical neurons are intrinsic properties of the cell itself. These studies include experiments on the reeler mouse mutant, and more recent attempts to manipulate developmental fates by pharmacological interventions and transplantation techniques. It is concluded that early commitment events in the cerebral cortex may specify a neuron's laminar position and restrict the range of potential axonal projections that the cell may form, but that local positional cues direct neurons to select (or maintain) only certain of the possible projections.
journal_name
Brain Resjournal_title
Brain researchauthors
McConnell SKdoi
10.1016/0165-0173(88)90002-1subject
Has Abstractpub_date
1988-01-01 00:00:00pages
1-23issue
1eissn
0006-8993issn
1872-6240journal_volume
472pub_type
杂志文章,评审相关文献
BRAIN RESEARCH文献大全abstract：:Sleep deprivation leads to cognitive impairments in humans and, if sustained for 2-3 weeks in rats, it is invariably fatal. It has been suggested that neural activity associated with waking, if it is not interrupted by periods of sleep, may damage brain cells through excitotoxic or oxidative mechanisms and eventually ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01768-0
更新日期：1999-09-04 00:00:00
abstract：:Mitochondrial division inhibitor (mdivi-1), a selective inhibitor of a mitochondrial fission protein dynamin-related protein 1 (Drp1), has been shown to exert protective effects in heart and cerebral ischemia-reperfusion models. The present study was designed to investigate the beneficial effects of mdivi-1 against sp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.03.033
更新日期：2015-09-04 00:00:00
abstract：:The Harderian gland of birds, a major lacrimal gland, contains a large population of lymphoid cells that produce IgA, a significant component of tears. Using histochemical techniques, we have examined the innervation of the gland. There was an extensive acetylcholine-esterase positive fiber network throughout the glan...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91331-9
更新日期：1985-02-25 00:00:00
abstract：:The ultrastructural features of the serotoninergic innervation of the rat dentate gyrus in normal adults and in animals receiving raphe nuclear area transplants was investigated using an antibody to serotonin (5-HT). Neonatal rats received a lesion of the fimbria-fornix and entorhinal cortex. Three days later, a porti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90509-3
更新日期：1986-03-26 00:00:00
abstract：:A substantial projection from the retina to the dorsal raphe nucleus (DRN) has been demonstrated in the Chilean degus, a diurnal/crepuscular hystricomorph rodent. Following intraocular injection of cholera toxin subunit B (CTB), immunocytochemically labeled CTB-positive axons and terminals were observed in all major r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02061-3
更新日期：2001-03-23 00:00:00
abstract：:Odorant-stimulated formation of cAMP in olfactory receptor neurons may mediate olfactory signal transduction. The response is short and desensitization occurs rapidly, possibly by induction of cyclic nucleotide phosphodiesterase (PDE) activity. Previously, we showed that two low Km PDEs regulate hydrolysis of cAMP in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91401-d
更新日期：1993-05-07 00:00:00
abstract：:Unilateral 6-hydroxydopamine (6-OHDA) lesions of substantia nigra pars compacta (SNPC) neurons in rats induce behavioural hypersensitivity to dopaminergic agonists. However, the role of specific dopamine receptors is unclear, and potential alterations in their transduction mechanisms remain to be evaluated. The presen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02927-4
更新日期：2001-11-30 00:00:00
abstract：:Extracellular recordings were made in vitro from 212 single units in the rat subfornical organ (SFO) and 54 single units in the rat medial preoptic area (MPO). Units were exposed to solutions made hyper-osmotic or hypo-osmotic by 1.4-11%. A reversible 30% or greater change in frequency followed the osmotic challenge i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90251-x
更新日期：1988-10-04 00:00:00
abstract：:Aluminum (Al) is among the most abundant elements on earth, it has been associated with the etiology of Alzheimer's disease. In the present study, AlCl(3) was administered with the dose of 10, 50 or 300 mg/kg b.wt/day through diet for 100 days. On day 101, overnight-fasted animals were sacrificed, the whole brains wer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.02.024
更新日期：2010-04-09 00:00:00
abstract：:Few clinical or experimental studies have carried out systematic investigations of cutaneous and deep sensibility in areas with referred muscle pain. Therefore, no clear signs of increased or decreased psychophysical responses to various somatosensory stimuli are found in referred pain areas. In the present study, a t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01077-3
更新日期：1997-01-02 00:00:00
abstract：:The response of the endoneurial vasculature in rat sciatic nerve following crush injury was investigated by morphometric analysis of serial nerve transverse sections at the site of injury and in distal segments at 1, 2, 3, 6, and 9 weeks after injury. Quantitative analysis included determination of the number of vesse...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90018-i
更新日期：1993-09-24 00:00:00
abstract：:An increase in medial perforant synaptic strength can be observed for hippocampal slices from rats exposed to environmental enrichment. The expression of enhanced synaptic strength exhibits properties similar to long-term potentiation (LTP), a physiological model of memory storage. Similarities include an increase in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00707-x
更新日期：1996-10-14 00:00:00
abstract：:In vitro assays offer a means of screening potential therapeutics and accelerating the drug development process. Here, we utilized neuronal cultures on planar microelectrode arrays (MEA) as a functional assay to assess the neurotoxicity of amyloid-β 1-42 (Aβ42), a biomolecule implicated in the Alzheimer׳s disease (AD)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.09.036
更新日期：2015-12-10 00:00:00
abstract：:Voltage-activated calcium channel currents were recorded from differentiated human neuroblastoma cells. SK-N-SH-SY5Y (SH-SY5Y) line, using patch-clamp techniques. Experimental solutions were designed to suppress sodium and potassium channel currents, and barium ions were used as the charge carrier. Two distinct types ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91300-h
更新日期：1993-02-12 00:00:00
abstract：:We examined the effects of nicotinic drugs on the metabolites of [3H]dopamine (DA) released from rat striatal synaptosomes in comparison with the effects of high K+ and methamphetamine stimulation. The pattern of outflow of [3H]DA and its metabolites induced by nicotine stimulants, acetylcholine (ACh), nicotine and lo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90204-4
更新日期：1983-11-21 00:00:00
abstract：:The regulation of corticosteroid receptor expression in the rat brain by adrenal steroids remains controversial. The results of in vivo studies [Brinton and McEwen, 1988; Luttge et al., 1989] suggest that activation of type I receptors can modulate both mineralocorticoid (MR; type I) and glucocorticoid (GR; type II) r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90174-0
更新日期：1994-02-04 00:00:00
abstract：:The effects of exo- and endogenous cGMP on the resting activity (RA) of afferent crista fibers were studied in isolated preparations of the statocysts of the cuttlefish Sepia officinalis and the squid Sepioteuthis lessoniana. Bath application of the membrane-permeable cGMP analogs 8-bromo-cGMP (B-cGMP) and N(2),2'-o-d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02777-3
更新日期：2000-10-13 00:00:00
abstract：:Previous studies have shown that one of the genetic variants BDNF val66met polymorphism is associated with drug addiction. Age at onset for drugs abuse has also been regularly cited as a factor associated with high genetic predispositions. We conducted an exploratory research to investigate the association of BDNF val...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.07.022
更新日期：2010-09-24 00:00:00
abstract：:A qualitative immunohistochemical study was performed on calcineurin A- and calbindin-positive neurons in the spinal cord of transgenic mice, an animal model of amyotrophic lateral sclerosis, carrying the G93A mutation of the Cu/Zn-superoxide dismutase gene. The results show that calcineurin A-immunoreactive motoneuro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03048-1
更新日期：2001-01-19 00:00:00
abstract：:The present study examines the brain-level representation and composition of meaning in scalar quantifiers (e.g., some), which have both a semantic meaning (at least one) and a pragmatic meaning (not all). We adopted a picture-sentence verification design to examine event-related potential (ERP) effects of reading inf...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.10.042
更新日期：2013-01-15 00:00:00
abstract：:The suprachiasmatic nuclei receive photic input information directly through a retinohypothalamic tract (RHT) and indirectly through a projection from the intergeniculate leaflet of the lateral geniculate complex, the geniculohypothalamic tract (GHT). Prior work has established that the RHT is sufficient for entrainme...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90374-5
更新日期：1988-09-20 00:00:00
abstract：:Benzodiazepine (BZ) site ligands affect vigilance, anxiety, memory processes, muscle tone and epileptogenic propensity through modulation of neurotransmission at GABA(A) receptors containing alpha1, alpha2, alpha3 or alpha5 subunits, and may have numerous experimental and clinical applications. The ability of non-sele...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.02.020
更新日期：2008-05-07 00:00:00
abstract：:The mRNA level of the 17-kDa protein neurogranin (NG), a postsynaptic substrate of the protein kinase C, has previously been found to be decreased in rat forebrain after 24-h sleep deprivation (SD). To investigate the functional significance of this finding in various forebrain regions, the effect of 24-h SD on the mR...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00416-n
更新日期：1995-07-10 00:00:00
abstract：:The immunohistochemical localization of an endogenous lectin R1 isolated from the rat cerebellum was studied during its postnatal development. The lectin is present in the cerebellum from birth to adulthood, essentially in lysosomes, multivesicular bodies, and parts of the endoplasmic reticulum, principally of large a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90148-8
更新日期：1985-01-01 00:00:00
abstract：:Many of our everyday actions are only appropriate in certain situations and selecting the appropriate behavior requires that we use current context and previous experience to guide our decisions. The current study examined hippocampal functional connectivity with prefrontal and striatal regions during a task that requ...
journal_title：Brain research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brainres.2011.09.038
更新日期：2011-11-14 00:00:00
abstract：OBJECTIVE:Previously, we found that the inhaled anesthetic isoflurane up-regulated the transcriptional factor hypoxia inducible factor (HIF)-1α protein levels during induction of neurodegeneration in the brain of neonatal rats. Here, we investigated the role of HIF-1α and the underlying signaling pathway in the neurode...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.10.014
更新日期：2016-12-15 00:00:00
abstract：:Facilitation of cerebellorubral transmission was illustrated in nembutalized cats on paired stimulation of the cerebellar nucleus interpositus by an example of monosynaptic EPSPs of the rubrospinal neurons. It was found that the facilitation stated is not determined by the change in the presynaptic volley of impulses....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90334-9
更新日期：1987-05-05 00:00:00
abstract：:Fasting induced a reduction in neuronal nitric oxide synthase (nNOS) mRNA in the paraventricular nucleus (PVN) and supraoptic nucleus (SON) of rats. The effect of intracerebroventricular (i.c.v.) administration of leptin on the nNOS mRNA level in the PVN and SON of fasting rats was studied by in situ hybridization his...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02065-x
更新日期：1999-11-06 00:00:00
abstract：:Long-term memory formation for passive-avoidance learning in the day-old chick is known to have two distinct time windows of protein synthesis (F.M. Freeman, S.P.R. Rose, A.B. Scholey, 1995. Two time windows of anisomycin-induced amnesia for passive-avoidance training in the day-old chick. Neurobiol. Learn. Mem. 63, 2...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02181-8
更新日期：2000-05-12 00:00:00
abstract：:In the present immunohistochemical study the distribution of nitric oxide synthase (NOS) was studied in various autonomic ganglia and in related peripheral tissues of the rat. For comparison some other neuronal markers including acetylcholinesterase and tyrosine hydroxylase as well as several neuropeptides were analys...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91483-4
更新日期：1994-09-12 00:00:00
