Abstract:
:Previous studies have shown that one of the genetic variants BDNF val66met polymorphism is associated with drug addiction. Age at onset for drugs abuse has also been regularly cited as a factor associated with high genetic predispositions. We conducted an exploratory research to investigate the association of BDNF val66met genetic polymorphism with the ages of onset for heroin abuse in males. Venous blood samples from 96 heroin-dependent persons were analyzed by Real-Time Fluorogenic PCR Assay to determine the genotype of BDNF val66met polymorphism. The effect of BDNF val66met genetic polymorphism on the age of onset for heroin abuse was analyzed in the patients of different genotypes. The observed genotype frequency was 32.29% (val66val; n=31), 45.83% (val66met; n=44), and 21.88% (met66met; n=21), which was similar with the reported results of Asians. The onset age was significantly different among the three genotypic groups, and val66met carriers had earlier onset of heroin abuse than did val66val and met66met carriers. Our findings further illustrate the role of BDNF genetic variants in drug abuse and dependence and this study will help to identify who are at risk of becoming heroin dependence in the future and decide the more appropriate timing that interventions should be taken in the high-risk groups.
journal_name
Brain Resjournal_title
Brain researchauthors
Hou H,Qing Z,Jia S,Zhang X,Hu S,Hu Jdoi
10.1016/j.brainres.2010.07.022subject
Has Abstractpub_date
2010-09-24 00:00:00pages
245-8eissn
0006-8993issn
1872-6240pii
S0006-8993(10)01584-2journal_volume
1353pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Phosphorylation of cyclic AMP response element binding protein (CREB) is one of the most important mechanisms controlling various gene transcriptions. In the present study, the phosphorylation of CREB was examined immunohistochemically at 24 h of recirculation following 1.5 h of middle cerebral artery occlusion (MCAO)...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01263-3
更新日期:1999-02-13 00:00:00
abstract::Many neurons release a variety of amino acids in response to depolarizing stimuli. Although some of these amino acids, namely, glutamate, aspartate, and gamma-aminobutyric acid (GABA), have been qualified as neurotransmitters, functional roles of the other amino acids including alanine remain obscure. We investigated ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03253-5
更新日期:2002-10-18 00:00:00
abstract::The aim of this study was to identify the medullary vagal nuclei involved in the different phases of swallowing activated physiologically in a species with an esophagus similar to human. In decerebrate cats, the pharyngeal (0.5-1.0 ml water in pharynx (N=6)) or esophageal (1-3 ml air in esophagus (N=5)) phases of swal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.03.061
更新日期:2004-07-16 00:00:00
abstract::The present study was designed to determine the types of acetylcholine receptors involved in the initiation of epileptic seizures from the zona incerta and surrounding structures by cholinergic stimulation in rats. Unilateral intracerebral microinjection of the mixed muscarinic and nicotinic agonist carbachol (3 micro...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90017-5
更新日期:1994-04-18 00:00:00
abstract::In the present study, the light responses of ganglion cells to chromatic stimulus were recorded from isolated retina of neonatal chick. It was found that for some non-color-opponent ganglion cells, the spatiotemporal patterns of the cells' light responses were related to the chromatic information that they received. W...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.07.077
更新日期:2005-10-12 00:00:00
abstract::It has been suggested that thiolic groups are essential for cytochrome c oxidase (COX) activity and other respiratory mitochondrial enzymes. Recent experiments showed that the thiolic antioxidant N-acetylcysteine (NAC) can protect against age-related impairment in COX activity in mice hepatic mitochondria. The present...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01819-3
更新日期:1999-09-18 00:00:00
abstract:PURPOSE:Diffusion kurtosis imaging (DKI) is a MRI technique which can measure alterations in the diffusion of water molecules to reflect tissue changes in both white and grey matter. This study evaluated the potential of DKI for the early diagnosis of radiation-induced temporal lobe changes in the grey and white matter...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.07.041
更新日期:2016-10-01 00:00:00
abstract::Motor behavior not seen in newborn cats can be revealed by spinal transection and is therefore normally suppressed. Motor performance of these spinal kittens after reaching adulthood surpasses that of chronic adult-operated spinal cats but the latter display a significant improvement when GABAergic inhibition is block...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90879-0
更新日期:1985-11-04 00:00:00
abstract::Solid pieces of the fetal septal region (SG) or hippocampus (HPC) were implanted in a cavity formed by aspiration of the fimbria fornix (FF) and the overlying cingulate cortex on one side in adult rats. In other lesioned animals cell suspensions obtained from the fetal septal area (SS) or the locus coeruleus region of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90632-9
更新日期:1987-01-06 00:00:00
abstract::Cell bodies and dendrites of neurones in the thalamic reticular nucleus projecting to the dorsal lateral geniculate nucleus in adult albino rats, were labelled by retrograde transport of horseradish peroxidase (HRP). In the same animals the terminals of cortico-reticular axons were made identifiable by ipsilateral vis...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90685-5
更新日期:1981-02-23 00:00:00
abstract::We examined whether there are the neurotransmitter candidate amino acid L-proline containing neurons localized in the rat brain. Antibodies against L-proline conjugated with rabbit serum albumin were raised in a rabbit and purified with affinity chromatography. Strong L-proline-like immunoreactivity was confined to se...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.12.064
更新日期:2006-02-16 00:00:00
abstract::The effects of psychological stress on catecholamine and indoleamine metabolism were examined in various brain regions of rats. Psychologically stressed rats were exposed to emotional responses of foot-shocked rats, but were themselves prevented from receiving foot-shock. Psychological stress for 30 min resulted in si...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90129-j
更新日期:1991-08-23 00:00:00
abstract::The distribution of melanin-concentrating hormone-like immunoreactivity (MCH-LI) in 41 microdissected brain and spinal cord regions was determined using radioimmunoassay with antibodies to salmon MCH. The highest concentration of MCH-LI was detected just ventral to the zona incerta (subzona incerta) (2923.2 fmol/mg pr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90337-9
更新日期:1986-05-14 00:00:00
abstract::Voltage-dependent calcium channels are important for calcium influx and the ensuing intracellular calcium signal in various excitable membranes. The beta subunits of these channels modify calcium currents through pore-forming alpha1 subunits of the high-voltage- activated calcium channels. In the present study, beta3 ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.05.041
更新日期:2007-07-30 00:00:00
abstract::The short term effects of spinal cord hemisection on protein synthesis in the Cebus monkey were studied by measuring the uptake of [3H]lysine into the trichloroacetic acid (TCA) precipitable and non-precipitable fractions of spinal cord. Animals were sacrificed 3, 6, or 13 days after hemisection. Two normal animals an...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)91046-5
更新日期:1976-07-23 00:00:00
abstract::Size matched male green anoles (Anolis carolinensis) were paired in a neutral setting and allowed to engage in aggressive displays. Winners and losers were apparent in each pair within 90min, resulting in stable dominant/subordinate dyads. Androgen receptor (AR) expression was assessed at three time points after the i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.07.028
更新日期:2014-09-25 00:00:00
abstract::Light-microscopical measurements have been made on teased pulpal nerve fibers from young adult cat canine teeth. In the root canal portion (apical to first branching point) the mean internodal length was approximately 250 micron. In the pulpal chamber portion (coronal to the first branching point) the pulpal nerve fib...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90221-x
更新日期:1984-06-11 00:00:00
abstract::In response to in vitro stimulation with lipopolysaccharide (LPS), microglia induce the production of the inflammatory cytokine interleukin-1 beta (IL-1β) together with nitric oxide (NO) and superoxide anion (O2(-)). Here we investigated the role of NO and O2(-) in the signaling mechanism by which IL-1β is induced in ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.08.030
更新日期:2015-11-02 00:00:00
abstract::The mechanisms responsible for the rate of rise (RR) of cumulative depolarization induced by dorsal root stimulus trains were investigated with intracellular recordings from motoneurones of the rat isolated spinal cord. The NMDA receptor antagonists CPP or APV depressed the cumulative depolarization but not its RR whi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)00997-3
更新日期:1996-11-04 00:00:00
abstract::Testosterone's (T) aggression-enhancing effects may be mediated in part by its 5alpha-reduced, 3-hydroxysteroid dehydrogenized metabolite 5alpha-androstane-3alpha,17beta-diol (3alpha-diol). To test this hypothesis, in Expt. 1 gonadectomized (gdx) C21 mice were administered T, 3alpha-diol, or vehicle and were observed ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03076-7
更新日期:2002-09-06 00:00:00
abstract:BACKGROUND:Perinatal brain injury in preterm infants is a major cause of neurological handicap. The role of the neurotrophin receptor p75 (p75(NTR)) in the pathogenesis and repair of neonatal excitotoxic brain injury is unknown. Depending on a complex interplay of neurotrophin signalling, p75(NTR) can, in addition to i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.07.095
更新日期:2010-10-08 00:00:00
abstract::The purpose of this experiment was to determine whether increased secretion of somatostatin or alterations in its molecular form contribute to the age-related decline in growth hormone secretion. Median eminences were removed from male Sprague-Dawley rats (3-4 and 21-24 months of age) and superfused with Krebs-Ringer ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90217-9
更新日期:1986-08-20 00:00:00
abstract::A single electrode voltage clamp was used to examine the prolonged hyperpolarizing afterpotential (PHA) which accompanies photoconversion of a substantial fraction of rhodopsin (lambda max = 500 nM) to metarhodopsin (lambda max = 575 nM) in distal photoreceptor cells in the retina of the bay scallop, Pecten irradians....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90539-x
更新日期:1982-05-13 00:00:00
abstract::N2O antinociception was assessed in eight inbred and two outbred mouse strains. Results indicated the following order of responsiveness among the 10 strains: A/J (most sensitive), C57BL/6ByJ, C57BL/6J, BALB/cByJ, C3H/HeJ, Swiss-Webster, CXBK/ByJ, ICR, CBA/J and DBA/2J (least sensitive). These results demonstrate signi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91017-m
更新日期:1993-06-18 00:00:00
abstract::The recent indications of specialized lateralization of cardiovascular regulation within the right and left posterior insular cortex of the rat, suggest the possibility of transcallosal connectivity between these regions. This has not been previously demonstrated using physiological techniques. Extracellular neural re...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02068-0
更新日期:2000-04-28 00:00:00
abstract::Coupling between lumbar motoneurons in the isolated frog spinal cord was studied by using intracellular recordings and intracellular injections of Lucifer Yellow CH. Physiological studies revealed intra- and intersegmental, short latency electrical interactions between many motoneurons. Injections of Lucifer Yellow in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90721-7
更新日期:1983-09-12 00:00:00
abstract::Stroke is the third leading cause of death in the US, with a prevalence of 750,000 patients per year, and a social cost estimated at $50 billion. Current therapeutics are targeted at restoring blood flow rather than on preventing the actual mechanisms associated with neuronal cell death. Here, we show that, following ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02922-0
更新日期:2002-08-30 00:00:00
abstract::To date several circuities in supraspinal site of the central nervous system have been known to engage in pain modulation. Lateral hypothalamus (LH) is known as part of the circuit of pain modulation among supraspinal sites. Its role in several animal pain models has been well defined. In this study, we examined the r...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.146674
更新日期:2020-04-01 00:00:00
abstract::Adhesion molecules on the endothelial surface of the blood-brain barrier (BBB) play an important role in the pathogenesis of many encephalopathies, including multiple sclerosis (MS) and cerebral malaria (CM). The expression of four surface molecules of relevance to MS and CM on the immortalized human umbilical vein en...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01436-5
更新日期:1999-06-05 00:00:00
abstract::Discharges of neurons in the midpontine dorsal tegmental field (DTF neurons) were recorded and analyzed during locomotion and were compared with those of reticulospinal neurons (RS neurons) located lateral to the DTF area. The conduction velocity of the descending axon of the DTF neurons was significantly smaller than...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91078-9
更新日期:1985-08-26 00:00:00