Abstract：
:It has been suggested that thiolic groups are essential for cytochrome c oxidase (COX) activity and other respiratory mitochondrial enzymes. Recent experiments showed that the thiolic antioxidant N-acetylcysteine (NAC) can protect against age-related impairment in COX activity in mice hepatic mitochondria. The present paper shows that NAC enhances COX activity in vitro in synaptic mitochondria isolated from young and old mice. The optimum NAC concentration for maximum COX activity was 5 mM in young and 10 mM in old synaptic preparations. Our data suggest that mitochondrial thiolic groups, which are essentials to oxidative phosphorylation, are impaired by aging.
journal_name
Brain Resjournal_title
Brain researchauthors
Martínez Banaclocha M,Martínez Ndoi
10.1016/s0006-8993(99)01819-3subject
Has Abstractpub_date
1999-09-18 00:00:00pages
249-51issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(99)01819-3journal_volume
842pub_type
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