Abstract：
:Cardiac arrest-induced cerebral hypoxic injury could induce posthypoxic movement disorders. Here we investigated the effects of memantine, an NMDA receptor channel blocker, on the neurodegeneration occurred in an established rat model of posthypoxic myoclonus. We found that administration of memantine for 7 days significantly reduced cerebral hypoxia-induced neurodegeneration in the CA1 of the hippocampus, the reticular thalamic nucleus (RTN) and the primary fissure of the cerebellum of the posthypoxic animals. The results suggest that the neurodegeneration observed in specific areas of the brain of the posthypoxic rats is contributed by NMDA receptor-mediated excitotoxicity.
journal_name
Brain Resjournal_title
Brain researchauthors
Tai KK,Truong DDdoi
10.1016/j.brainres.2006.11.076subject
Has Abstractpub_date
2007-02-16 00:00:00pages
209-15issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(06)03469-Xjournal_volume
1133pub_type
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