Noradrenergic innervation of human pineal gland: abnormalities in aging and Alzheimer's disease.

Abstract:

:Using previously characterized polyclonal antibody directed against dopamine beta-hydroxylase (DBH), immunoreactive fibers were demonstrable in pineals of 6 controls of various ages and of 3 individuals with Alzheimer's disease (AD). Abnormal, swollen axons were present in pineals from aged individuals and from individuals with AD. The pathology of noradrenergic axons in a structure innervated by the superior cervical ganglion suggests that peripheral noradrenergic systems may be affected in aging and in AD.

journal_name

Brain Res

journal_title

Brain research

authors

Jengeleski CA,Powers RE,O'Connor DT,Price DL

doi

10.1016/0006-8993(89)90818-4

subject

Has Abstract

pub_date

1989-03-06 00:00:00

pages

378-82

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(89)90818-4

journal_volume

481

pub_type

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