Dietary arginine fails to protect against cerebrovascular damage in stroke-prone hypertensive rats.

abstract：:Electrode-implanted rats pressed a lever to self-stimulate a reward mechanism in their lateral hypothalamus (LH) each time with a brief train of pulses. Interdigitation of a medial hypothalamus (MH) train into the ipsilateral LH train inhibited the reward as indicated by a reduced lever pressing rate. Such interdigita...

journal_title：Brain research

authors： Porrino LJ,Coons EE,MacGregor B

更新日期：1983-10-31 00:00:00

abstract：:Following single injections of horseradish peroxidase (HRP) in the superior colliculus (SC) and [3H]proline in the striate cortex of rats, a close correspondence was observed in the topographical arrangements of extrastriate cortical fields of HRP retrograde label and of isotope anterograde label. These results suppor...

journal_title：Brain research

authors： Olavarria J,Van Sluyters RC

更新日期：1982-06-24 00:00:00

abstract：:Neurofibrillary tangles (NFT) are pathological cytoskeletal structures composed of paired helical filaments (PHF), and are found in neurons of patients afflicted with many neurodegenerative disorders, including Alzheimer's disease (AD). We previously found that an antiserum against casein kinase II (CK-II) stained NFT...

journal_title：Brain research

authors： Baum L,Masliah E,Iimoto DS,Hansen LA,Halliday WC,Saitoh T

更新日期：1992-02-21 00:00:00

abstract：:Stress stimulates the adrenal medulla to rapidly secrete catecholamines (CAs), and the adrenal cortex to release progesterone (PROG), which may locally regulate stress-induced CA release. We used bovine chromaffin cells to investigate the effects of PROG on CA secretion. PROG dose-dependently inhibited CA secretion in...

journal_title：Brain research

authors： Armstrong SM,Stuenkel EL

更新日期：2005-05-10 00:00:00

abstract：:Opiates and cannabinoids are among the most widely consumed habit-forming drugs in humans. Several studies have demonstrated the existence of interactions between both kind of drugs in a variety of effects and experimental models. The present study has been focused to determine whether perinatal delta9-tetrahydrocanna...

journal_title：Brain research

authors： Vela G,Martín S,García-Gil L,Crespo JA,Ruiz-Gayo M,Fernández-Ruiz JJ,García-Lecumberri C,Pélaprat D,Fuentes JA,Ramos JA,Ambrosio E

更新日期：1998-10-05 00:00:00

abstract：:Recently, [125I]S(-)5-OH-PIPAT (5-hydroxy-2-(N-n-propyl-N-3'-iodo-2'-propenyl)amino-tetralin) was reported to be a selective radioiodinated ligand for dopamine D2-like receptors. This ligand displayed a high binding affinity (Kd = 0.3-0.4 nM) and an agonist binding profile to dopamine D2 and D3 receptors expressed in ...

journal_title：Brain research

authors： Vessotskie JM,Kung MP,Chumpradit S,Kung HF

更新日期：1997-12-05 00:00:00

abstract：:This study was designed to describe renal afferent information with respect to its intraspinal projections, convergence with cutaneous inputs, ascending projections, and modulation by descending fiber tracts. Extracellular recordings were made from neurons in the spinal gray while electrically stimulating the renal ne...

journal_title：Brain research

authors： Knuepfer MM,Akeyson EW,Schramm LP

更新日期：1988-04-12 00:00:00

abstract：:Pituitary adenylate-cyclase activating polypeptide (PACAP) is a neuropeptide originally isolated from the hypothalamus and located in many neuronal systems in both the central and peripheral nervous system. PACAP is also found in nerve fibers innervating the pineal gland, where it stimulates the secretion of the pinea...

journal_title：Brain research

authors： Møller M,Baeres FM

更新日期：2003-09-12 00:00:00

abstract：:Event-related brain potentials were used to study the neural mechanisms underlying goal-directed object use distinguishing between processes supporting immediate and final action goals during action planning and execution. Subjects performed a grasping and transportation task in which actions were cued either with the...

journal_title：Brain research

authors： van Schie HT,Bekkering H

更新日期：2007-05-07 00:00:00

abstract：:The density of specific prostaglandin E2 (PGE2) binding sites was quantitatively mapped in the rat brain using in vitro autoradiography. The anterior wall of the third ventricle and the nucleus solitary tract were found to have a very high density of binding sites (greater than 15 fmol/mg tissue). Two thalamic nuclei ...

journal_title：Brain research

authors： Matsumura K,Watanabe Y,Imai-Matsumura K,Connolly M,Koyama Y,Onoe H,Watanabe Y

更新日期：1992-05-29 00:00:00

abstract：:Experimental and genetic hypertension in male rate is accompanied by a lower specific [3H]naloxone binding in the dorsal horn of the spinal cord, and in the hippocampus as compared to controls. Rats which are genetically resistant to hypertensive stimuli have a higher specific [3H]naloxone binding in the nucleus tract...

journal_title：Brain research

authors： Zamir N,Segal M,Simantov R

更新日期：1981-05-25 00:00:00

abstract：:The distributions of serotonin and catecholamines were examined within the central ganglia of juvenile Achatina through the histological localization of serotonin-like immunoreactivity and of glyoxylic acid-induced fluorescence. Somata containing these amines were widely distributed throughout all central ganglia exce...

journal_title：Brain research

authors： Croll RP

更新日期：1988-09-13 00:00:00

abstract：:In intracellular recordings from the CA1 region of the hippocampal slice preparation, an infrequent cell type different from the predominant pyramidal cell has been characterized. The cells have very brief spikes, hyperpolarizing after-potentials, and tend to fire at a high spontaneous rate; unitary synaptic potential...

journal_title：Brain research

authors： Schwartzkroin PA,Mathers LH

更新日期：1978-11-17 00:00:00

abstract：:The localization of vasoactive intestinal peptide (VIP)-like immunoreactivity was investigated in the brain, olfactory system and retina of the zebrafish, Danio rerio, during development and in juvenile specimens, by using the indirect immunofluorescence and the peroxidase-antiperoxidase methods. In 24 h post fertiliz...

journal_title：Brain research

authors： Mathieu M,Tagliafierro G,Angelini C,Vallarino M

更新日期：2001-01-12 00:00:00

abstract：:The effect of high acetaldehyde (ACe) on acetylcholine (ACh) release was studied in vivo in the medial frontal cortex (mfc) of freely moving rats using brain microdialysis coupled with high performance liquid chromatography and an electrochemical detector. Ethanol (EtOH) and ACe concentrations were quantified simultan...

journal_title：Brain research

authors： Jamal M,Ameno K,Wang W,Kumihashi M,Ameno S,Ikuo U,Shinji A,Ijiri I

更新日期：2005-03-28 00:00:00

abstract：:After glucocorticoid stimulation, glucocorticoid receptors (GRs) are translocated to the nucleus to modulate transcription of glucocorticoid target genes. The subcellular distribution and trafficking of GR in cultured cells has been studied quite intensively using several techniques. However, the intracellular localiz...

journal_title：Brain research

authors： Sarabdjitsingh RA,Meijer OC,de Kloet ER

更新日期：2010-05-17 00:00:00

abstract：:Stimulation frequency thresholds for lateral hypothalamic self-stimulation were monitored for 3 weeks following the induction of diabetes with streptozotocin (STZ). In each of the 3 weeks following STZ treatment, thresholds of diabetic rats were significantly lower than their pre-STZ baseline while thresholds of contr...

journal_title：Brain research

authors： Carr KD

更新日期：1994-11-21 00:00:00

abstract：:Corticotropin-releasing factor (CRF) has been hypothesized to be involved in the pathophysiology of anxiety, depression, cognitive and feeding disorders. Two distinct CRF receptor subtypes, CRFR1 and CRFR2, are thought to mediate CRF actions in the CNS. However, the role for each receptor subtype in animal models of n...

journal_title：Brain research

authors： Contarino A,Dellu F,Koob GF,Smith GW,Lee KF,Vale W,Gold LH

更新日期：1999-07-17 00:00:00

abstract：:Multidrug efflux transporters of the ATP-Binding cassette (ABC) family, P-glycoprotein (Pgp), multidrug-resistance associated protein 4 (MRP4) and breast cancer resistance protein (BCRP), located on endothelial cells lining brain vasculature play important roles in limiting movement of substances into and enhancing th...

journal_title：Brain research

authors： Wijesuriya HC,Bullock JY,Faull RL,Hladky SB,Barrand MA

更新日期：2010-10-28 00:00:00

abstract：:The effects of dopamine D1 and D2 selective drugs on the responses evoked in accumbens neurons by stimulation of cortical afferents were studied in an in vitro brain slice preparation. The D2-specific antagonist sulpiride (1-10 microM) increased, whereas the D2 agonist quinpirole (1-20 microM) occasionally attenuated ...

journal_title：Brain research

authors： O'Donnell P,Grace AA

更新日期：1994-01-14 00:00:00

abstract：:Previous studies have indicated that amyloid precursor protein (APP) might be a trophic agent in the nervous system, possibly through the regulation of cell adhesion and the protease/protease inhibitor activity. Additionally, APP is upregulated during the development of the nervous system. In order to further study th...

journal_title：Brain research

authors： Masliah E,Mallory M,Ge N,Saitoh T

更新日期：1992-10-16 00:00:00

abstract：:Ontogeny of somatostatin (SRIF) neuron system of the rat cerebellum was investigated by means of the indirect immunofluorescent method. In addition, several operations were performed to provide the evidence of understanding the cerebellar SRIF innervation. SRIF-positive structures appeared in the primordium of the cer...

journal_title：Brain research

authors： Inagaki S,Shiosaka S,Takatsuki K,Iida H,Sakanaka M,Senba E,Hara Y,Matsuzaki T,Kawai Y,Tohyama M

更新日期：1982-04-01 00:00:00

abstract：:In alert monkeys, some prefrontal neurons located in the superior dorsolateral area were activated to acoustic stimuli delivered in a restricted range of directions with respect to the animal's head. The effective direction was usually contralateral to the animal. The function of the auditory neurons in connection to ...

journal_title：Brain research

authors： Azuma M,Suzuki H

更新日期：1984-04-30 00:00:00

abstract：:It has been hypothesized that a disruption of gamma-aminobutyric acid (GABA) receptor-mediated processes may be involved in the pathophysiology of focal epilepsy. This disinhibition hypothesis has been postulated from the results of in vitro experiments of the interictal activity of focal epilepsy. Less is known, howe...

journal_title：Brain research

authors： Higashima M,Ohno K,Kinoshita H,Koshino Y

更新日期：2000-05-26 00:00:00

abstract：:Following pulse labeling with [3H]arachidonic acid ([3H]AA), its incorporation pattern in brain reflects regional changes in neurotransmitter signal transduction using phospholipase A2, that is, functional activity. In a rat model of Parkinson's disease, unilateral 6-hydroxydopamine lesion in the substantia nigra, [3H...

journal_title：Brain research

authors： Hayakawa T,Chang MC,Bell JM,Seeman R,Rapoport SI,Appel NM

更新日期：1998-10-05 00:00:00

abstract：:Ischemic-reperfusion injury in humans occurs in conditions such as stroke, cardiac arrest, subarachnoid hemorrhage or head trauma. Maximal tissue damage is observed during reperfusion, which is primarily attributed to oxidative injury resulting from production of oxygen free radicals. One of the major consequences of ...

journal_title：Brain research

authors： Panigrahi M,Sadguna Y,Shivakumar BR,Kolluri SV,Roy S,Packer L,Ravindranath V

更新日期：1996-04-22 00:00:00

abstract：:There is increasing evidence that traumatic brain injury (TBI) induces hypofunction of the striatal dopaminergic system, the mechanisms of which are unknown. In this study, we analyzed the activity of striatal tyrosine hydroxylase (TH) in rats at 1 day, 1 week, and 4 weeks after TBI using the controlled cortical impac...

journal_title：Brain research

authors： Shin SS,Bray ER,Zhang CQ,Dixon CE

更新日期：2011-01-19 00:00:00

abstract：:The alpha7 nicotinic acetylcholine receptor (nAChR) plays an important role in cognitive processes and has generated recent interest as a potential drug target for treating neurodegenerative disorders such as Alzheimer's disease (AD). The property of Ca(2+) permeation associated with alpha7 nAChR agonism may lead to C...

journal_title：Brain research

authors： Bitner RS,Nikkel AL,Markosyan S,Otte S,Puttfarcken P,Gopalakrishnan M

更新日期：2009-04-10 00:00:00

abstract：OBJECTIVE:This study aimed to investigate whether β-amyloid (Aβ) was able to enhance neurocan expression in a Sox9 dependent manner in astrocytes. METHODS AND MATERIALS:Astrocytes were incubated with Aβ at different concentrations, the expression of Sox9 and neurocan was detected by Western blot assay. Meanwhile, the ...

journal_title：Brain research

authors： Yan H,Zhu X,Xie J,Zhao Y,Liu X

更新日期：2016-09-01 00:00:00

abstract：:The present study determined whether cortical cholinergic neurons recover functionally following the loss of afferent projections from the nucleus basalis magnocellularis (nbm). At various time points following ibotenic acid lesions of the nbm, choline acetyltransferase (ChAT) activity or the capacity of cortical chol...

journal_title：Brain research

authors： Lapchak PA,Araujo DM,Pasinetti G,Hefti F

更新日期：1993-06-11 00:00:00