Abstract：
:Following pulse labeling with [3H]arachidonic acid ([3H]AA), its incorporation pattern in brain reflects regional changes in neurotransmitter signal transduction using phospholipase A2, that is, functional activity. In a rat model of Parkinson's disease, unilateral 6-hydroxydopamine lesion in the substantia nigra, [3H]AA acid incorporation from blood was increased in cerebral cortex, caudate putamen, globus pallidus, entopeduncular nucleus, subthalamic nucleus and substantia nigra pars reticulata ipsilateral to the lesion. This increased [3H]AA incorporation likely reflects disinhibition of basal ganglia and cortical circuits secondary to absent inhibitory nigrostriatal dopaminergic input.
journal_name
Brain Resjournal_title
Brain researchauthors
Hayakawa T,Chang MC,Bell JM,Seeman R,Rapoport SI,Appel NMdoi
10.1016/s0006-8993(98)00751-3subject
Has Abstractpub_date
1998-10-05 00:00:00pages
177-81issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(98)00751-3journal_volume
807pub_type
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