Abstract:
:A diffusion model is described here, which allows for the estimations of drug concentration changes in porous media, such as in slice tissues of the central nervous system (CNS) bathed in unstirred solutions following abrupt changes of drug concentration. This model may be used for the interpretation of data obtained in neuropharmacological studies if (i) the diffusion coefficient of the molecules under investigation is constant within the excised tissue, (ii) drug molecules are diffusing only in the extracellular space (ECS) and are not bound by the tissue, (iii) drug molecules diffuse mainly within one dimension, (iv) the drug concentration in the bath is changed within 5 s, and (v) the bathing solutions at the surfaces of the slices are stagnant during the period of diffusion. To test this model, estimated tetramethylammonium (TMA) ion concentrations within a tissue slice were compared to actual TMA concentration changes measured at the same depth in the tissue of hippocampal slices by means of TMA-sensitive microelectrodes. A statistically significant correlation (P less than 0.05) was observed between the estimated and measured TMA concentrations which indicates that the model is valid under the defined conditions.
journal_name
Brain Resjournal_title
Brain researchauthors
Lipinski HG,Bingmann Ddoi
10.1016/0006-8993(87)91523-xsubject
Has Abstractpub_date
1987-12-22 00:00:00pages
26-34issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(87)91523-Xjournal_volume
437pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Following the administration of horseradish peroxidase (HRP) in the middle or lower cervical cord segments of neonatal (1-10 days), developing (15-20 days) and mature (2-4 months) albino rats, labeled pyramidal neurons were found in layer V of the cerebral cortex. They formed one continuous band of labeled neurons in ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91327-6
更新日期:1983-04-11 00:00:00
abstract::Striatal kainic acid (KA) lesions induce behavioral and biochemical deficits which resemble symptoms encountered in patients suffering from Huntington's disease. In rats with KA lesions, fetal striatal transplants have shown to reverse the pervasive nocturnal hyperactivity induced by the lesion. In the present study 4...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91313-3
更新日期:1988-04-12 00:00:00
abstract::In the present study, the light responses of ganglion cells to chromatic stimulus were recorded from isolated retina of neonatal chick. It was found that for some non-color-opponent ganglion cells, the spatiotemporal patterns of the cells' light responses were related to the chromatic information that they received. W...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.07.077
更新日期:2005-10-12 00:00:00
abstract::Accumulating evidence indicates that neurite degeneration occurs via a distinct mechanism from somal death programs. We have previously shown that neuritic ATP level in sympathetic neurons decreases, whereas somal ATP level remains unaltered during degeneration caused by the microtubule-disrupting agent, vinblastine. ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.09.050
更新日期:2004-12-24 00:00:00
abstract::L-Tryptophan produces a significant antihypertensive effect in spontaneously hypertensive rats while D-tryptophan does not change blood pressure. Both isomers of tryptophan significantly increase brain serotonin to the same extent at a time when the antihypertensive effect of L-tryptophan is maximal. Thus, the antihyp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90985-5
更新日期:1984-03-19 00:00:00
abstract::Huntington's disease (HD) is a fatal, genetic, neurodegenerative disorder characterized by deficits in motor and cognitive function. Here, we have quantitatively characterized motor deficiencies and dopamine release dynamics in transgenic HD model rats. Behavioral analyses were conducted using a newly-developed force-...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.02.042
更新日期:2012-04-23 00:00:00
abstract::Following the implantation of cobalt-gelatine pellets into the frontal cortex, epileptiform spikes in both primary and secondary foci developed and reached a peak between 7-12 days post implantation. Histological examination showed a necrotic lesion with terminal and fibre degeneration in brain areas connected with th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90288-7
更新日期:1975-07-25 00:00:00
abstract::Fluorescence resonance energy transfer (FRET) is a widely utilized optical technique for measuring small distances of 1-10 nm in live cells. In recent years, its application has been greatly popularized by the discovery of green fluorescent protein (GFP) and many improved variants which make good donor-acceptor fluoro...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2006.01.119
更新日期:2006-05-26 00:00:00
abstract::Facial allodynia is a migraine symptom that is generally considered to represent a pivotal point in migraine progression. Treatment before development of facial allodynia tends to be more successful than treatment afterwards. As such, understanding the underlying mechanisms of facial allodynia may lead to a better und...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.03.011
更新日期:2017-06-01 00:00:00
abstract::Responsiveness of single inferotemporal (IT) neurons to a tone as a start or warning signal in each test trial was investigated in monkeys performing visual discrimination of 4 patterns. It was found that the same IT neurons were responsive to both auditory signal and visual discriminanda with different response chara...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(87)80031-8
更新日期:1987-04-28 00:00:00
abstract::Previous work provided indirect evidence that planarians undergo abstinence-induced withdrawal from cocaine. The present study's purpose was to determine if planarians display withdrawal signs and, if so, to quantify the behaviors. Planarians were soaked in cocaine then transferred to either the same cocaine concentra...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.10.052
更新日期:2005-01-25 00:00:00
abstract::Kinins, such as bradykinin and Lys-bradykinin, are important mediators in peripheral inflammation. Although the existence of the components necessary for generating kinins has been demonstrated in the brain, a functional role of the kinin-generating system in cerebral inflammation remains to be defined. The aim of the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02768-9
更新日期:2003-07-18 00:00:00
abstract::As previously demonstrated, spontaneously firing bulbar inspiratory neurones are periodically inhibited either at the beginning of, or throughout expiration, while bulbar expiratory neurones are inhibited during inspiration. The aim of the present study was to test the hypothesis that amino acids act as transmitters o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90447-4
更新日期:1982-04-15 00:00:00
abstract::The effects of indomethacin (10 mg/kg) on the release of the transmitter amino acids, glutamate, aspartate, GABA, and of the purines, adenosine and inosine, from the cerebral cortex was studied in a four-vessel occlusion rat model of cerebral ischemia/reperfusion. In comparison with the control group, indomethacin sig...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90248-8
更新日期:1994-08-01 00:00:00
abstract::A series of experiments were performed to study the effects of learning upon proteins in the split-brain pigeon. With this preparation, one side of the brain was trained in a color discrimination task while the other side served as a naive control. Proteins from both sides of the brain were separated by one- and two-d...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90349-2
更新日期:1980-09-29 00:00:00
abstract::Growth factor-dependent proliferation of neuronal progenitors is an essential stage in CNS development. Although several of these growth factors have been identified, high levels of neuregulin 1 (NRG1) mRNA and protein expression in the CNS during the time of neuronal progenitor expansion suggest NRG1 growth factors m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.06.025
更新日期:2006-09-07 00:00:00
abstract::Neovascularization within syngeneic rat fetal neocortical grafts transplanted into a previously prepared cavity in the cerebral cortex was studied 1 to 3 months after transplantation, utilizing scanning electron microscopy of vascular corrosion casts. The grafts were easily identified and the outer surface of the graf...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00304-9
更新日期:1995-05-29 00:00:00
abstract::The localization of immunoreactive glutamic acid decarboxylase (GAD) and enkephalin-like immunoreactivity was examined in serial, 4-micron frozen sections of the caudate nucleus from rats pretreated with colchicine. Colocalization was found in numerous caudate neurons of medium size. Cell counts of corresponding label...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90850-3
更新日期:1984-05-23 00:00:00
abstract::A subset of olfactory receptor neurons of the Caribbean spiny lobster Panulirus argus possesses receptors for L-glutamate that can mediate both excitatory and inhibitory responses (P.C. Daniel, M.F. Burgess, C.D. Derby, Responses of olfactory receptor neurons in the spiny lobster to binary mixtures are predictable usi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00816-0
更新日期:1997-10-17 00:00:00
abstract::The identification of biologically important and chemically well-defined substances that can promote axon and dendrite formation would improve present understanding of the development of the nervous system. Physiological concentrations of insulin and insulin-like growth factor-II (IGF-II) reversibly enhanced neurite o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90246-4
更新日期:1984-06-08 00:00:00
abstract::In situ hybridization (ISH) is an essential technique for mapping gene expression in the brain. Although many ISH protocols provide for quantitative analysis of individual mRNAs in different brain regions or across experimental conditions, this technique has lacked the necessary standardization for quantitative compar...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.11.069
更新日期:2004-03-12 00:00:00
abstract::Murine brain cells differentiated for 19 days in culture before treatment for 5 days with 10 microM diazepam. Radioligand binding to the benzodiazepine receptors on membranes obtained from these cultures was determined by the filtration assay method. Decreased binding was observed in the membranes from treated culture...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90117-8
更新日期:1983-12-12 00:00:00
abstract::Because the occurrence of rapid eye movement (REM) sleep is critically dependent upon an animal's thermal balance, acute pharmacological treatments may effect REM sleep through effects on thermoregulation. We describe how manipulating ambient temperature (T(a)) alters the REM sleep-suppressing effects of systemically-...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90184-8
更新日期:1994-02-04 00:00:00
abstract::These experiments were designed to test the hypothesis that the TxA2 mimetic, U46,619, would stimulate group III and IV afferent nerve endings from the hindlimb of the anesthetized cat. Nerve impulses were recorded from the dorsal rootlets of the L7-S1 segments of the spinal cord, and afferent units identified by meas...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01211-5
更新日期:1997-01-02 00:00:00
abstract::Multiple dose administration of methamphetamine (MA) results in long-lasting toxic effects in the nigrostriatal dopaminergic system. These effects are considered to be primarily due to oxidative damage mediated by increased production of hydrogen peroxide or other reactive oxygen species in the dopaminergic system. Th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02122-8
更新日期:1999-12-18 00:00:00
abstract::Serotonin (5-HT), dopamine (DA) and noradrenaline (NE) play important roles in brain postnatal maturation. Therefore, deficits in brain availability of biogenic amines during critical developmental phases might underlie neurodevelopmental disturbances associated with cognitive impairment. To test this hypothesis we ev...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.04.006
更新日期:2008-06-27 00:00:00
abstract::The purpose of this study was to determine the effects of specific proinflammatory cytokines interleukin-6 (Il-6), interleukin-1beta (Il-1beta), interferon-gamma (IFN), and tumor necrosis factor-alpha (TNFalpha), on content and distribution of alpha-synuclein (alpha-synuclein), tau and ubiquitin in human derived cultu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.03.081
更新日期:2008-06-27 00:00:00
abstract::Radial glial cells of the embryonic murine cerebral wall are selectively labeled by staining with antibody RC1. In order to study the mitotic cycling of these cells, we combined RC1 immunohistochemistry and autoradiographic analysis following [3H]thymidine injection at 1, 2, 6, 48 h prior to sacrifice. Many radial gli...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(88)90043-0
更新日期:1988-02-01 00:00:00
abstract::We examined the effects of systemic administration of gamma-vinyl gamma-aminobutyric acid (GVG), a gamma-aminobutyric acid (GABA) transaminase inhibitor, on the kindling model of epilepsy in rats. GVG (1200 or 1500 mg/kg) approximately doubled the number of stimulations required for kindling development. GVG also supp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91498-8
更新日期:1986-11-29 00:00:00
abstract::Increasing evidence indicates that volatile general anesthetics exert their effects by affecting various types of membrane conductance expressed in the central nervous system (CNS), such as ligand-gated receptor-channels. The most recently identified family of the receptor-channels in the CNS are the extracellular ATP...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03125-0
更新日期:2001-12-07 00:00:00