Abstract：
:These experiments were designed to test the hypothesis that the TxA2 mimetic, U46,619, would stimulate group III and IV afferent nerve endings from the hindlimb of the anesthetized cat. Nerve impulses were recorded from the dorsal rootlets of the L7-S1 segments of the spinal cord, and afferent units identified by measurement of conduction velocities, mechanical probing of hindlimb muscles, and local injection of chemical stimulants (capsaicin and bradykinin). Five of the 15 group III fibers were stimulated by U46,619 (2-10 micrograms injected into the abdominal aorta; mean baseline impulse frequency increasing from 7.3 (+/- 3.2) impulses/s to 16.0 (+/- 3.1)), while 7 of the 12 group IV fibers responded to U46,619 (impulse frequency increasing from 4.3 (+/- 3.2) to 8.8 (+/- 3.6)). The average latency for the response (20-30 s) did not differ between the two groups of afferent fibers. We conclude that group III and IV afferent fibers originating from the skeletal muscle of the hindlimb are stimulated by TxA2 and that the release of TxA2 in skeletal muscle could evoke cardiorespiratory reflexes known to be activated by stimulation of these afferent nerves.
journal_name
Brain Resjournal_title
Brain researchauthors
Kenagy J,VanCleave J,Pazdernik L,Orr JAdoi
10.1016/s0006-8993(96)01211-5subject
Has Abstractpub_date
1997-01-02 00:00:00pages
175-8issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(96)01211-5journal_volume
744pub_type
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