Abstract：
:We examined whether there are the neurotransmitter candidate amino acid L-proline containing neurons localized in the rat brain. Antibodies against L-proline conjugated with rabbit serum albumin were raised in a rabbit and purified with affinity chromatography. Strong L-proline-like immunoreactivity was confined to several groups of neurons in the arcuate nucleus (n) and supraoptic n in the hypothalamus and area postrema. The brainstem had markedly stained fibers in the medial longitudinal fasciculus and localized neuronal cell body labeling in the red n, mesencephalic trigeminal n, lateral reticular n, raphe obscurus n, solitary n, compact ambiguus n, motor trigeminal n and n of trapezoid body. Our findings are consistent with the hypothesis that L-proline may function as a neurotransmitter or neuromodulator in the brain.
journal_name
Brain Resjournal_title
Brain researchauthors
Takemoto Y,Semba Rdoi
10.1016/j.brainres.2005.12.064subject
Has Abstractpub_date
2006-02-16 00:00:00pages
311-5eissn
0006-8993issn
1872-6240pii
S0006-8993(05)01733-6journal_volume
1073-1074pub_type
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