Abstract：
:The muscarinic cholinergic receptor of rat eccrine sweat gland was characterized using quantitative autoradiography and [3H]QNB as radioligand. The distribution of radioligand was maximal in the secretory coil. Autoradiographic competition binding studies were performed using selective antagonists to M1 (pirenzepine), M2 (AF-DX 116), and M3 (4-DAMP) and the classical nonselective antagonist atropine. pKi for pirenzepine, AF-DX 116, 4-DAMP, and atropine was 6.58, 5.47, 8.50, and 8.66 respectively indicating that the eccrine sweat gland muscarinic receptor was predominantly M3.
journal_name
Brain Resjournal_title
Brain researchauthors
Torres NE,Zollman PJ,Low PAdoi
10.1016/0006-8993(91)90415-rsubject
Has Abstractpub_date
1991-05-31 00:00:00pages
129-32issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(91)90415-Rjournal_volume
550pub_type
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