Pharmacological properties and monoaminergic mediation of the slow IPSP, in mammalian sympathetic ganglion.

Abstract:

:Phenoxybenzamine can selectively eliminate the s-IPSP, in the presence of anti-cholinesterases that enhance s-IPSP and s-EPSP; and the alpha 2-antagonist, yohimbine, can partially but consistently depress s-IPSP selectively. The results provide positive pharmacological support for the monoaminergic nature of the transmitter for s-IPSP in mammalian sympathetic ganglia and argue against suggestions that the s-IPSP is a direct hyperpolarizing response to acetylcholine.

journal_name

Brain Res

journal_title

Brain research

authors

Ashe JH,Libet B

doi

10.1016/0006-8993(82)90321-3

subject

Has Abstract

pub_date

1982-06-24 00:00:00

pages

345-9

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(82)90321-3

journal_volume

242

pub_type

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