Abstract：
:The effect of arginine vasopressin (AVP) on protein phosphorylation in rat hippocampal synaptic plasma membranes (SPM) was examined. With a crude SPM preparation, AVP (10(-8)-10(-5) M) stimulated phosphorylation of a number of proteins which included a brain-specific protein of 48 kDa called B50 or protein F1, which is thought to be related to synaptic plasticity. Equimolar levels of oxytocin also stimulated B50/F1 phosphorylation. AVP and oxytocin at higher concentrations (10(-4)-10(-3) M) reduced SPM protein phosphorylation. When SPM was treated with both AVP and oxytocin, the effects were not additive; on the other hand, the effects of the phorbol ester (TPA) and AVP were additive. With SPM, partially purified by sucrose density centrifugation, only the inhibitory effect of AVP on B50/F1 phosphorylation was seen. These results suggest that AVP and oxytocin stimulation of B50/F1 phosphorylation requires cellular factors which are removed from SPM during membrane purification. In contrast, the inhibitory mechanism triggered by AVP and oxytocin appears to be associated with, or an integral part of, the synaptic membrane itself. Because the effects on membrane protein phosphorylation with maximal amounts of AVP and oxytocin were not additive, they must bind to the same sites on the membrane. This conclusion is supported by the additivity of the effects of AVP and phorbol ester, since the phorbol ester can act directly on the kinase and does not require a membrane recognition site.
journal_name
Brain Resjournal_title
Brain researchauthors
Hinko A,Kim Y,Pearlmutter AFdoi
10.1016/0006-8993(86)91231-xsubject
Has Abstractpub_date
1986-10-01 00:00:00pages
156-60issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(86)91231-Xjournal_volume
384pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Multiple dose administration of methamphetamine (MA) results in long-lasting toxic effects in the nigrostriatal dopaminergic system. These effects are considered to be primarily due to oxidative damage mediated by increased production of hydrogen peroxide or other reactive oxygen species in the dopaminergic system. Th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02122-8
更新日期：1999-12-18 00:00:00
abstract：:Morphological alterations occurring in Schwann cells of unmyelinated fibers (unmyelinated Schwann cells) were investigated in the sciatic nerve of the twicher mouse, a murine model of human globoid cell leukodystrophy. After postnatal day 10, the number of Schwann cell-axon units gradually increased and the number of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91719-8
更新日期：1989-11-27 00:00:00
abstract：:The effects of microinjection of alpha-noradrenergic agonists and antagonists in the flocculus on the basic gain and adaptibility of vestibulo-ocular and optokinetic responses were investigated. A complementary, previous investigation had shown that the adaptation, but not the basic performance, of compensatory oculom...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90623-4
更新日期：1991-10-25 00:00:00
abstract：:The nigrostriatal projection was studied with a retrograde tracing method (Evans blue, EB) combined with a technique for dopamine histofluorescence. The study, realized in control rats and in animals with 6-hydroxydopamine-induced lesions of the dopaminergic pathway, yielded the following results. (1) In 3 control rat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90235-3
更新日期：1981-06-01 00:00:00
abstract：:A decrease in the number of neuronal profiles in the isocortex of man may be observed on microscopic sections in aging and in degenerative diseases such as Alzheimer's disease. It can be the consequence of a loss of neurons per unit volume or of a reduction of the neuronal volume (i.e. pseudo-loss). This latter possib...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91602-8
更新日期：1989-12-11 00:00:00
abstract：:Voltage-clamped GABA(A fast) and GABA(A slow) inhibitory postsynaptic currents (IPSCs) were selectively elicited in hippocampal area CA1 pyramidal neurons. Clinically relevant concentrations of halothane (1.2 vol.%) prolonged both GABA(A fast) and GABA(A slow) IPSC decay times approximately 2.5 fold, while having litt...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00516-7
更新日期：1997-08-08 00:00:00
abstract：:Avian circadian rhythms are regulated by a multiple oscillatory system consisting of the pineal, the suprachiasmatic nucleus (SCN) and the eye. In the present study, ontogeny of circadian clock in the pineal and the SCN of chick embryo was examined using Per2 expression as a marker. A daily rhythmicity of Per2 express...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03531-5
更新日期：2003-11-14 00:00:00
abstract：:In the adult central nervous system (CNS), GABA and glycine (Gly) are predominant inhibitory neurotransmitters, negatively regulating glutamatergic transmission. In the immature CNS, on the other hand, they act as trophic factors, mediating morphogenesis. In the present study, to investigate their involvement in axona...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.01.048
更新日期：2012-03-29 00:00:00
abstract：:The effect of isradipine, a dihydropyridine calcium antagonist, on morphine-induced place preference and analgesia in rats and mice was studied. Isradipine (0.6-5.0 mg/kg s.c.) inhibited an acquisition of morphine-induced place preference in rats and mice in a dose-related manner. Isradipine did not affect or strength...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91311-2
更新日期：1992-10-16 00:00:00
abstract：:Increasing evidence indicates that volatile general anesthetics exert their effects by affecting various types of membrane conductance expressed in the central nervous system (CNS), such as ligand-gated receptor-channels. The most recently identified family of the receptor-channels in the CNS are the extracellular ATP...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03125-0
更新日期：2001-12-07 00:00:00
abstract：:The muscarinic cholinergic receptor of rat eccrine sweat gland was characterized using quantitative autoradiography and [3H]QNB as radioligand. The distribution of radioligand was maximal in the secretory coil. Autoradiographic competition binding studies were performed using selective antagonists to M1 (pirenzepine),...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90415-r
更新日期：1991-05-31 00:00:00
abstract：:Administration of methyl palmoxirate (MP), an inhibitor of fatty acid oxidation, stimulates eating behavior in rats. Fos immunohistochemistry was used to determine neural pathways that may play a role in the eating response to MP. The number of cells showing Fos-like immunoreactivity (Fos-li) was quantified by compute...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01143-8
更新日期：1998-01-19 00:00:00
abstract：:In an autopsy study on 29 male Aborigines and 57 male Caucasians, macroscopic and microscopic parameters of postnatal cerebellar development were determined and described by mathematic growth functions. For the whole cerebellum and its cortical layers volume measurements revealed delayed maturation for Aborigines comp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90782-8
更新日期：1989-10-16 00:00:00
abstract：:MPTP is a neurotoxin thought to damage dopaminergic neurons through free radical formation. MPTP is metabolized in the brain to MPP(+), which is taken up into dopaminergic neurons via the dopamine transporter and assumed to impair mitochondrial function. We used striatal synaptosomes and telencephalic mitochondria to ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02675-1
更新日期：2003-06-13 00:00:00
abstract：:The involvement of striatal cholinergic neurons in the release of dopamine (DA) elicited by the mu-opioid receptor agonist DAGO ([D-Ala2, NMePhe4-Gly5(ol)]enkephalin) was explored. The striatal release of DA was measured by microdialysis in rats anesthetized with chloral hydrate. When infused in the striatum, through ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/S0006-8993(96)01319-4
更新日期：1997-02-28 00:00:00
abstract：:Multiple retrograde fluorescent tracing was employed to investigate the organization of the rat entopeduncular nucleus projections to the lateral habenula, ventral anterior-ventral lateral thalamus, parafasicular-centre median complex, and tegmenti pedunculopontis area of the brain stem. The results indicate that neur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90064-0
更新日期：1981-04-27 00:00:00
abstract：:Movements of medium and large sized membranous organelles (0.5-1 microns in diameter) were visualized within segments of the crab walking leg nerve with Nomarski differential interference contrast optics and subjected to video contrast enhancement. Accessibility to the axoplasm was demonstrated by intra-axonal fluores...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91754-g
更新日期：1993-03-12 00:00:00
abstract：:Dantrolene sodium, a skeletal muscle relaxant, was investigated for its action on single motor units of the peroneus tertius muscle in cats anaesthetized with pentobarbitone sodium. Motor axons were isolated in ventral root filaments and their muscle units were identified as either fast-fatiguable (FF), fast-resistant...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90631-5
更新日期：1983-02-21 00:00:00
abstract：:Adult Wistar rats injected with the dopamine receptor agonist apomorphine display different types of motility patterns with respect to oral stereotypes and locomotor activities. It was tested whether phenotypes exhibiting either 'sniffing' or 'non-sniffing' behaviour differed in gene structures of dopamine receptors D...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03136-5
更新日期：2002-02-01 00:00:00
abstract：:To determine the contribution of presynaptic cholinergic mechanisms to the increased sensitivity of a genetically selected line of Sprague-Dawley rats (Flinders S-line) to the anticholinesterase, diisopropyl fluorophosphate (DFP), rats were sacrificed by focused microwave irradiation of the head 1 min after a pulse in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91044-8
更新日期：1984-03-05 00:00:00
abstract：:Chronic total sleep deprivation (TSD) of rats by the disk-over-water method reliably produces initial increases and subsequent decreases in waking intraperitoneal (Tip) and hypothalamic (Thy) temperatures, progressive increases in energy expenditure, skin lesions on the tail and plantar surfaces, debilitated appearanc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01071-8
更新日期：1995-12-12 00:00:00
abstract：:Previous work from this laboratory has documented that glutamate receptor activation and extracellular calcium entry into hippocampal neurons caused a long-lasting down-regulation of ligatin mRNA and protein. Here, we investigated whether glutamate reduced ligatin mRNA levels by decreasing the transcriptional activity...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00599-l
更新日期：1995-09-25 00:00:00
abstract：:The competitive CB1 receptor antagonist SR141716A was used to test the hypothesis that endogenous cannabinoids modulate tonic pain sensitivity. Pretreatment with the antagonist significantly enhanced the response to a chemical nociceptive stimulus in the formalin test. Postreatment with the antagonist 5 min following ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01031-2
更新日期：1998-12-07 00:00:00
abstract：:Involvement of N-methyl-D-aspartate (NMDA) receptor complex and 5-hydroxytryptamine3 (5-HT3) receptors in state-dependent learning (SDL) induced by ethanol (EtOH) was investigated in the step-through passive avoidance task in rats. Pre-training injections of EtOH or MK-801 reduced step-through latency in the test sess...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01040-8
更新日期：1996-01-15 00:00:00
abstract：:Systemic administration of mesenchymal stem cells (MSCs) following cerebral infarction exerts functional improvements. Previous research has suggested potential therapeutic mechanisms that promote neuroprotection and synaptogenesis. These include secretion of neurotrophic factors, remodeling of neural circuits, restor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.05.033
更新日期：2018-09-15 00:00:00
abstract：:The present study examined the effects of excitotoxins which activate distinct excitatory amino acid (EAA) receptor subtypes on the levels of Methionine-enkephalin-like immunoreactivity (ME-i.r.) in the striatum and globus pallidus, with a view to developing a model of the striatopallidal enkephalin deficit that preva...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90029-b
更新日期：1990-12-17 00:00:00
abstract：:Uptake of 5-hydroxytryptamine (5-HT) by adult and fetal rabbit's ileum was studied. The adult myenteric plexus accumulated tritium when incubated with tritiated 5-HT. However, in addition to labeled 5-HT, tritiated 5-hydroxyindole acetic acid and, when monoamine oxidase (MAO) was inhibited, 5-HT-o-glucuronide were fou...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90360-7
更新日期：1976-10-22 00:00:00
abstract：:Adult Sprague-Dawley rats were exposed to a single session of 100 inescapable tail shocks (IS). Bromodeoxyuridine (BrdU) was administered 1 h, 2 days or 7 days later and hippocampal cell proliferation (CP) was assessed after a 2-h survival period. Measures of plasma corticosterone (CORT) levels were also obtained. Des...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.10.081
更新日期：2007-01-26 00:00:00
abstract：:After injections of 6-hydroxydopamine (6-OHDA) along the medial forebrain bundle in the lateral hypothalamus, rats failed to acquire a one-way active avoidance response or failed to perform a previously acquired active avoidance response. Such rats, however, acquired a passive avoidance response and a conditioned tast...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90659-9
更新日期：1975-05-09 00:00:00
abstract：:In neonates, ventilatory responses to hypoxia are 'biphasic,' with an augmentation followed by a decline. The hypoxia-induced augmentations in ventilation are attenuated and the depressions are accentuated following denervation of the peripheral chemoreceptors. Piglets that were decerebrated at a rostral mesencephalic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01310-9
更新日期：1999-02-20 00:00:00
