Abstract：
:Pregabalin is useful for treating neuropathic pain, but known to increase body weight as a side effect. To investigate the mechanism of this increase in body weight, we focused on dopamine in the lateral hypothalamus (LH) and examined the effects of pregabalin on dopamine levels in the LH and food intake. The dopamine levels in the LH was gradually decreased during fasting. When the animals were fed, dopamine levels in the LH was significantly increased, indicating that dopamine levels in the LH reflects energy state. The systemic injection of pregabalin tended to decrease dopamine levels in the LH after feeding. The dopamine levels in the LH was also significantly increased by glucose injection, which was inhibited by pregabalin. These results suggest that pregabalin inhibits dopaminergic function in the LH, which might increase food intake. To make these points clear, we examined the effects of pregabalin on food intake and blood glucose levels. Pregabalin significantly increased food intake, whereas pregabalin did not affect blood glucose levels. These results indicate that pregabalin stimulates feeding behavior, but not glucose metabolism. Moreover, the non-selective dopamine receptor antagonist cis-(Z)-flupenthixol injected into the LH significantly increased food intake, though neither the dopamine D1 receptor antagonist SCH 23390 nor the D2 receptor antagonist l-sulpiride injected into the LH affected food intake. These results indicate that the inhibition of dopaminergic function in the LH increases food intake. In conclusion, the present results suggest that pregabalin increases food intake through the inhibition of dopaminergic functions in the LH.
journal_name
Brain Resjournal_title
Brain researchauthors
Ikeda H,Yonemochi N,Ardianto C,Yang L,Kamei Jdoi
10.1016/j.brainres.2018.09.026subject
Has Abstractpub_date
2018-12-15 00:00:00pages
219-226eissn
0006-8993issn
1872-6240pii
S0006-8993(18)30492-Xjournal_volume
1701pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Thermoregulation is a complex intercommunicative function requiring coordination between core body temperature (CBT), the central nervous system, and peripheral vasculature. In menopausal women, dysregulation of thermoregulatory mechanisms leads to hot flushes and night sweats. A previous study in ovariectomized (OVX)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.09.050
更新日期：2006-12-06 00:00:00
abstract：:The present study was undertaken to disclose temporal changes in the distribution of Fos-like immunoreactive (-IR) neurons in the trigeminal subnucleus caudalis (SpVc), one of the important relay nuclei for processing the nociceptive information from the oro-facial regions, following induction of experimental tooth mo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01323-7
更新日期：1999-02-20 00:00:00
abstract：:This study investigated the effects of the calcium channel blockers nicardipine, calcicludine, omega-conotoxin GVIA, omega-agatoxin IVA, SNX-482, and NiCl on spontaneous muscle action potential of a rat spinal cord-muscle co-culture system. Spontaneous muscle action potential of the innervated muscle cells was blocked...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.11.057
更新日期：2005-02-09 00:00:00
abstract：:To assess the role of calcitonin gene-related peptide (CGRP) within the trigeminal subnucleus caudalis (Vc) on adrenal and autonomic function, microinjections were directed at different laminae of Vc in chloralose-anesthetized cats. Microinjections of CGRP (5 pmol, 100 nl) into laminae I-II increased significantly the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90713-6
更新日期：1991-08-30 00:00:00
abstract：:The highly rigid and conformationally extended 2-amino-4-phosphonobutanoic acid (AP4) analogue (RS)-1-amino-3-(phosphonomethylene)-cyclobutane-1-carboxylic acid (cyclobutylene AP5) was synthesized and found to inhibit evoked responses in the rat lateral perforant path (LPP) with an IC50 of 41 (+/- 1.5 S.E.M.) microM a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90525-e
更新日期：1992-01-31 00:00:00
abstract：:Nesfatin-1, an 82-amino acid peptide encoded by the secreted precursor nucleobinin-2 (NUCB2), exerts potent anorexigenic action independently of leptin signaling. This propensity has propelled this peptide and its analogues as potential anti-obesity drug candidates. However, a more extensive comprehension of its biolo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.01.032
更新日期：2019-05-15 00:00:00
abstract：:The distribution of radioactivity after injection of [3H]testosterone was studied in the forebrain of adult mice by thaw-mount autoradiography. Nuclear labeling was high in neurons in the dorsal part of the medial nucleus of the amygdala and in the dorsocaudal part of the bed nucleus of the stria terminalis. Low nucle...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90630-x
更新日期：1986-11-12 00:00:00
abstract：:We compared the clinical and pharmacodynamic effects of N-terminal methionine brain-derived neurotrophic factor (met-BDNF) and endogenous met-free BDNF in wobbler mouse motor neuron disease (MND). Met- or met-free BDNF at 5 or 20 mg/kg was subcutaneously injected daily, six times/week for 4 weeks. At 20 mg/kg, grip st...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02881-0
更新日期：2002-07-19 00:00:00
abstract：:The objective of this study was to determine whether the aging process influences the changes in the electrophysiological properties of motoneurons that occur as a consequence of axotomy. Accordingly, using intracellular recording and stimulating techniques, the basic electrical properties of control (unaxotomized) an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90594-y
更新日期：1992-01-20 00:00:00
abstract：:Variation in cell loss and mossy fiber reorganization was examined along the longitudinal axis of the dentate gyrus from temporal lobe epileptic (TLE) patients. Previous evidence has indicated that the anterior hippocampus is prone to seizure activity. We compared granule and hilar cell number in addition to Timm stai...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00167-o
更新日期：1995-04-24 00:00:00
abstract：:In order to investigate the interplay between visuo-spatial attention and central attention, we varied the relative probability (25% vs. 75%) of the responses to lateralized targets in an attentional blink paradigm. When the first target was associated with a less probable response, we observed a larger attentional bl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.09.004
更新日期：2007-12-14 00:00:00
abstract：:The carotid body of the mouse is ideally suited for in vitro photometric and fluorometric studies using transillumination. It is small, thin and translucent. Photometric recordings were made by using a dual wavelength method. Wavelengths of 550 nm (maximal absorbance, MA) and 540 nm (isosbestic point, IP) were employe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90019-8
更新日期：1985-03-18 00:00:00
abstract：:Structural changes induced by high frequency (HF) stimulation on granule cells of the hippocampal dentate gyrus of rats with inborn high (HP) and low (LP) learning capacity was examined in this study. Two types of axodendritic synapses were processed morphometrically; the axonal bouton on dendritic shafts and those ma...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90371-h
更新日期：1990-12-24 00:00:00
abstract：:Serotonin (5-HT) participates in pain modulation by interacting with different 5-HT receptors. The role of 5-HT5A receptor in neuropathic pain has not previously studied. The purpose of this study was to investigate: A) the role of 5-HT5A receptors in rats subjected to spinal nerve injury; B) the expression of 5-HT5A ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.06.043
更新日期：2015-10-05 00:00:00
abstract：:Phenotypic diversity is shaped by both genetic and epigenetic mechanisms that program tissue specific patterns of gene expression. Cells, including neurons, undergo massive epigenetic reprogramming during development through modifications to chromatin structure, and by covalent modifications of the DNA through methyla...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2008.07.074
更新日期：2008-10-27 00:00:00
abstract：:Deltamethrin is a highly potent pyrethroid insecticide that causes hypersensitivity, choreoathetosis, tremors, and paralysis in mammals. It is known to modify the sodium channel in such a way as to prolong the tail current associated with step repolarization following a depolarizing pulse. Using the axial-wire voltage...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90879-e
更新日期：1992-07-03 00:00:00
abstract：:A major function of the dopamine in the striatum is to control the activity of its efferent systems which contain primarily GABAergic neurons. Direct intracerebral injections of haloperidol into the corpus striatum impaired the performance of rats trained to depress a lever in a sensitive reaction time task. Rats were...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90186-8
更新日期：1989-04-03 00:00:00
abstract：:Rats predisposed to develop diet-induced obesity (DIO) preferentially activate their sympathetic nervous system during intracarotid glucose infusion [B.E. Levin, Intracarotid glucose-induced norepinephrine response and the development of diet-induced obesity, Int. J. Obesity 16 (1992) 451-457.] but their brains are ge...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00839-7
更新日期：1998-10-19 00:00:00
abstract：:The amygdala is a bilateral temporal lobe brain region which plays an important role in emotional processing. Past studies on the amygdala have shown hemispheric differences in amygdalar processes and responses associated with specific pain and fear behaviors. Despite the functional differences in the amygdala, few st...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.10.028
更新日期：2018-01-01 00:00:00
abstract：:The transcription factor Phox2b is necessary for the development of the nucleus of the solitary tract (NTS). In this brainstem nucleus, Phox2b is expressed exclusively within a subpopulation of glutamatergic neurons. The present experiments in the adult rat were designed to test whether this subpopulation includes the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.05.072
更新日期：2008-08-21 00:00:00
abstract：:After a moderate global cerebral ischemia, two hypothetical populations of pyramidal neurons are present among the hippocampal CA1 pyramidal neurons: one that will die and another one that will survive. Prior analysis of dissected hippocampal CA1 regions has shown a reduction of the GluR1-3 mRNA following ischemia. In...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)01985-0
更新日期：2001-03-09 00:00:00
abstract：:In the cat, cells of the superior colliculus (SC) and the tectofugal pathways of the visual system are highly selective for the direction of a moving visual stimulus. Deep layer units of SC in addition respond to auditory and somatosensory stimuli, but the proportion of such non-visual cells is usually found to be muc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90430-7
更新日期：1989-06-19 00:00:00
abstract：:Choline molecules are needed for the synthesis of acetylcholine and phospholipids in the mammalian brain. An enzymatic activity capable of forming lecithin (phosphatidylcholine) from the step-by-step methylation of phosphatidylethanolamine is identified in the bovine brain. This enzyme(s), phosphatidylethanolamine-N-m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90447-5
更新日期：1979-12-28 00:00:00
abstract：:Natural food sources constitute a promising source of new compounds with neuroprotective properties, once they have the ability to reach the brain. Our aim was to evaluate the brain accessibility of quercetin, epigallocatechin gallate (EGCG) and cyanidin-3-glucoside (C3G) in relation to their neuroprotective capabilit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.09.020
更新日期：2016-11-15 00:00:00
abstract：:Two-month-old male offspring of rats injected intravenously on day 19 of gestation with antiserum to synaptic membrane fraction showed marked behavioral deficits on a DRL (differential reinforcement at low rates) training paradigm. These behavioral deficits included perseveration, slow acquisition rates, and poor rete...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90325-x
更新日期：1975-07-18 00:00:00
abstract：:Effects of methamphetamine (MAP) on the extracellular neuropeptide Y (NPY) and noradrenaline (NA) levels were examined in the vicinity of the paraventricular nucleus (PVN) of freely moving rats by means of push-pull perfusion. The NA and NPY levels increased significantly in 30-60 min and reached the maximum level in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01343-1
更新日期：1996-01-22 00:00:00
abstract：:Treated carbon fiber electrodes were used with differential normal pulse voltammetry (DNPV) for in vivo determination of the relative participation of uric acid (UA) to peak 3 derived between 250-300 mV in the dorsal horn of the spinal cord of anesthetized rats. In vitro, treated carbon fiber electrodes respond linear...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90584-1
更新日期：1987-09-01 00:00:00
abstract：:Despite insights into an increasingly significant role for delta opioid receptors in thermoregulation, it is unclear whether delta receptors located in the brain or periphery play the more critical role in body temperature regulation. Moreover, it is not entirely clear which delta receptor phenotype, delta1 or delta2,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.04.074
更新日期：2005-07-05 00:00:00
abstract：:The development of afferent projections to the cerebellum was studied by making small (20 nl) injections of True blue into the cerebella of neonatal rats under general anaesthesia. Neurones in all main precerebellar nuclei were labelled even in rats less than one day old. With the exception of the disappearance of sma...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90037-5
更新日期：1988-04-01 00:00:00
abstract：:The present study investigated differences between vestibulo-somatic and vestibulo-sympathetic reflexes, along with differences between somatic and autonomic spino-bulbo-spinal (SBS) reflexes in chloralose-urethane anesthetized cats. Electrical stimulation was applied to the vestibular nerve (V) for a duration of 0.3 ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90221-5
更新日期：1985-05-20 00:00:00
