Phasic but not tonic REM-selective discharge of periaqueductal gray neurons in freely behaving animals: relevance to postulates of GABAergic inhibition of monoaminergic neurons.

Abstract:

:To determine if ventrolateral periaqueductal gray contains neurons that selectively increase their discharge activity before and during rapid eye movement (REM) sleep, and hence might furnish GABAergic inhibition of monoaminergic neurons, we recorded the extracellular activity of 33 neurons across sleep-wakefulness in freely behaving cats. Several types of state-specific neuronal populations were found in the periaqueductal gray, although we did not find any neurons that had a tonic discharge increase before and during REM. Thus, these data suggest that, although periaqueductal gray neurons may regulate phasic components of REM sleep, they do not have the requisite tonic pre-REM and REM activity to be a source of GABAergic inhibition of monoaminergic neurons.

journal_name

Brain Res

journal_title

Brain research

authors

Thakkar MM,Strecker RE,McCarley RW

doi

10.1016/s0006-8993(02)02914-1

subject

Has Abstract

pub_date

2002-08-02 00:00:00

pages

276-80

issue

2

eissn

0006-8993

issn

1872-6240

pii

S0006899302029141

journal_volume

945

pub_type

杂志文章
  • Sensory deafferentation and olfactory bulb morphology in the zebrafish and related species.

    abstract::The zebrafish, Danio rerio, has become an important model species for examining olfactory system structure and function, yet little is known about developmental changes in olfactory bulb morphology from embryo to adult. The present study examined both normal growth and the effects of deafferentation on the bulb from h...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)02412-9

    authors: Poling KR,Brunjes PC

    更新日期:2000-02-21 00:00:00

  • Central interactions between angiotensin II and PGD(2) in the regulation of vasopressin and oxytocin secretion in dehydrated rats.

    abstract::Brain-derived angiotensin II (ANG II) and prostaglandins have important roles in the regulation of body fluid and blood pressure homeostasis. In the present studies we investigated the central interactions between these two neurochemical products in regulating the hypothalamo-neurohypophysial system during dehydration...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(00)03113-9

    authors: Kadekaro M,Terrell ML,Bui V,Summy-Long JY

    更新日期:2001-01-19 00:00:00

  • Dye and electrical coupling between frog motoneurons.

    abstract::Coupling between lumbar motoneurons in the isolated frog spinal cord was studied by using intracellular recordings and intracellular injections of Lucifer Yellow CH. Physiological studies revealed intra- and intersegmental, short latency electrical interactions between many motoneurons. Injections of Lucifer Yellow in...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)90721-7

    authors: Brenowitz GL,Collins WF 3rd,Erulkar SD

    更新日期:1983-09-12 00:00:00

  • Awaking effect of PGE2 microinjected into the preoptic area of rats.

    abstract::We examined the effect of prostaglandin (PG)E2 on the sleep-wake activity and on body temperature by microinjecting PGE2 into the preoptic area of rats that had been chronically implanted with guide cannulae and electrodes for the recordings of electroencephalogram and electromyogram. PGE2 at doses of 2.5 X 10(-13), 2...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90935-3

    authors: Matsumura H,Goh Y,Ueno R,Sakai T,Hayaishi O

    更新日期:1988-03-22 00:00:00

  • Laminar origins of spinal projection neurons to the periaqueductal gray of the rat.

    abstract::Attempts were made to determine the cells of origin of the spinal projections to the PAG using retrograde axoplasmic transport techniques of HRP and fluorescent markers. Following injections limited to the lateroventral subnucleus of the PAG, labels were transported to the contralateral laminae I, III, V, VII and X pr...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)91127-7

    authors: Liu RP

    更新日期:1983-03-28 00:00:00

  • The synthesis and distribution of the kinin B1 and B2 receptors are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy.

    abstract::Kinins, a special class of polypeptides, are represented by bradykinin (BK), kallidin (Lys-BK), as well as their metabolites. The biological actions of these polypeptides binding on their receptors (B1 and B2) have been related to inflammation process, cytokines action, glutamate release and prostaglandins production....

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2003.12.050

    authors: Argañaraz GA,Silva JA Jr,Perosa SR,Pessoa LG,Carvalho FF,Bascands JL,Bader M,da Silva Trindade E,Amado D,Cavalheiro EA,Pesquero JB,da Graça Naffah-Mazzacoratti M

    更新日期:2004-04-23 00:00:00

  • Membrane properties of deep dorsal horn neurons from neonatal rat spinal cord in vitro.

    abstract::Whole-cell patch-clamp recordings were undertaken to characterize and compare the membrane properties of deep dorsal horn neurons in transverse slices of rat lumbar spinal cord in two age groups, postnatal days (P) 3-6 and 9-16. In both age groups, significant correlations were observed between membrane time constant ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00578-7

    authors: Hochman S,Garraway SM,Pockett S

    更新日期:1997-09-05 00:00:00

  • Biosynthesis of myelin-associated proteins in simian virus 40 (SV40)-transformed rat Schwann cell lines.

    abstract::In order to study the biosynthesis of myelin-associated proteins in Schwann cells, we have induced proliferation of cultured Schwann cells from neonatal rat sciatic nerve by transformation with Simian Virus 40 (SV40). Homogeneous transformed Schwann cell lines were established by single cell cloning. The transformed p...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)91324-2

    authors: Chen GL,Halligan NL,Lue NF,Chen WW

    更新日期:1987-06-23 00:00:00

  • Time course of reinnervation of the olfactory bulb after transection of the primary olfactory nerve in the pigeon.

    abstract::Horseradish peroxidase (HRP) histochemistry was used to study the time course of reinnervation of the pigeon olfactory bulb after simple transection of the primary olfactory nerve. At selected intervals (9, 13, 29, 61 and 93 days) after transection of the right olfactory nerve, a concentrated solution of HRP was insti...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)00361-s

    authors: Jennings RA,Hambright Keiger CJ,Walker JC

    更新日期:1995-06-19 00:00:00

  • Generalization of seizures parallels the formation of "dark" neurons in the hippocampus and pontine reticular formation after focal-cortical application of 4-aminopyridine (4-AP) in the rat.

    abstract::Distribution and time course of the occurrence of "dark" neurons were compared with the EEG activity and behavior of rats during 4-aminopyridine (4-AP) induced epileptic seizures. A crystal of the K(+) channel blocker 4-AP (0.5 mg/kg) was placed onto the exposed parieto-occipital cortex of Halothane-anesthetized rats ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2008.06.044

    authors: Baracskay P,Szepesi Z,Orbán G,Juhász G,Czurkó A

    更新日期:2008-09-04 00:00:00

  • Effects of dietary fat and enterostatin on dopamine and 5-hydroxytrytamine release from rat striatal slices.

    abstract::Studies have demonstrated defects of DA and 5HT neurotransmission in dietary fat induced obese animals. In the present study, we used a perfusion system to assay the release of DA and 5HT from striatal slices preloaded with [(3)H]-DA or [(3)H]-5HT. The release of both DA and 5HT from striatal slices of rats fed a high...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.06.036

    authors: York DA,Teng L,Park-York M

    更新日期:2010-08-19 00:00:00

  • Evaluation of the effects of testosterone and luteinizing hormone on regulation of β-amyloid in male 3xTg-AD mice.

    abstract::During normal aging, men experience a significant decline in testosterone levels and a compensatory elevation in levels of gonadotropin luteinizing hormone (LH). Both low testosterone and elevated LH have been identified as significant risk factors for the development of Alzheimer's disease (AD) in men. It is unclear ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2012.05.011

    authors: Rosario ER,Carroll JC,Pike CJ

    更新日期:2012-07-23 00:00:00

  • Musical scale properties are automatically processed in the human auditory cortex.

    abstract::While listening to music, we immediately detect 'wrong' tones that do not match our expectations based on the prior context. This study aimed to determine whether such expectations can occur preattentively, as indexed by event-related potentials (ERPs), and whether these are modulated by attentional processes. To this...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.08.023

    authors: Brattico E,Tervaniemi M,Näätänen R,Peretz I

    更新日期:2006-10-30 00:00:00

  • The effects of intracranial administration of the dopamine agonist apomorphine on penile reflexes and seminal emission in the rat.

    abstract::Previous studies employing systemic administration of the dopamine agonist apomorphine have shown that the dose response curves for apomorphine's effects on penile reflexes and seminal emission differ, suggesting that experimentally separable populations of dopamine receptors regulate these two responses. The present ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)90328-4

    authors: Pehek EA,Thompson JT,Hull EM

    更新日期:1989-10-23 00:00:00

  • Calcitonin gene-related peptide (hCGRP alpha) binding sites in the nucleus accumbens. Atypical structural requirements and marked phylogenic differences.

    abstract::The distribution of [125I]hCGRP alpha binding sites was studied in tissue sections from rat brain and, at the level of the nucleus accumbens in the brains of 6 other species. In the rat, very high levels of binding were found in the nucleus accumbens, the amygdaloid complex and mammillary body while high amounts were ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90686-p

    authors: Dennis T,Fournier A,Guard S,St Pierre S,Quirion R

    更新日期:1991-01-18 00:00:00

  • Prostaglandin E1 modifies porcine cerebral arterial tone through cyclooxygenase related eicosanoid(s) release.

    abstract::The effects of prostaglandin E1 (PGE1) on porcine cerebral arteries were studied in the absence and presence of cyclooxygenase inhibitors, 5 x 10(-6) M indomethacin or 10(-4) M aspirin. In preparations placed at a resting tension, 3 x 10(-9) to 10(-6) M PGE1 caused dose-dependent contractions. In prostaglandin F2 alph...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)91096-2

    authors: Fukuda S,Taga K,Tsukui A,Nishimura N,Kumagai Y,Shimoji K

    更新日期:1989-09-04 00:00:00

  • Brain-derived neurotrophic factor expression is increased in the rat amygdala, piriform cortex and hypothalamus following repeated amphetamine administration.

    abstract::The amygdala plays an important role in the regulation of motivational states, especially those associated with addiction. The amygdala also expresses high levels of brain-derived neurotrophic factor (BDNF), an activity-dependent neurotrophin that can influence the reinforcing and locomotor activating properties of ps...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)03160-8

    authors: Meredith GE,Callen S,Scheuer DA

    更新日期:2002-09-13 00:00:00

  • Impact of prefrontal intermittent theta-burst stimulation on working memory and executive function in Parkinson's disease: A double-blind sham-controlled pilot study.

    abstract::Cognitive impairment is a prevalent non-motor feature of Parkinson's disease (PD) which can present even in early stages of the disease. Impairments in executive processing and working memory (WM) are common and have been attributed, in part, to abnormalities within the dorsolateral prefrontal cortex (DLPFC) and broad...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2019.146506

    authors: Hill AT,McModie S,Fung W,Hoy KE,Chung SW,Bertram KL

    更新日期:2020-01-01 00:00:00

  • Effect of morphine tolerance and abstinence on the binding of [3H]MK-801 to brain regions and spinal cord of the rat.

    abstract::The effect of chronic administration of morphine to rats on the N-methyl-D-aspartate (NMDA) receptors labeled with [3H]MK-801, a non-competitive antagonist, was determined in brain regions and spinal cord. Male Sprague-Dawley rats were rendered tolerant to and physically dependent on morphine by subcutaneous implantat...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)91740-x

    authors: Gudehithlu KP,Reddy PL,Bhargava HN

    更新日期:1994-03-14 00:00:00

  • Alterations in delta opioid receptor levels in discrete areas of the neocortex and in the globus pallidus of the aging guinea pig: a quantitative autoradiographic study.

    abstract::The effect of aging on delta opioid receptors was examined in the brains of guinea pigs aged 1, 6, 24 and 36 months. Quantitative autoradiography was used to monitor the concentrations of delta receptors in various anatomical regions at five rostro-caudal levels. delta opioid receptor populations were found to be rema...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)91021-j

    authors: Hiller JM,Fan LQ,Simon EJ

    更新日期:1993-06-18 00:00:00

  • Specificity of histiotypic organization and synaptogenesis in reaggregating cell cultures of mouse cerebellum.

    abstract::The fine structure of reaggregating cultures of cells from 6- to 7-day-old mouse cerebellum was studied at intervals between 3 and 21 days in vitro (DIV). The resulting aggregates consisted mainly of small neurons (granule, stellate and basket cells), neuroglial cells and their processes. Large neurons were rarely pre...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(84)90067-1

    authors: Orkand PM,Lindner J,Schachner M

    更新日期:1984-09-01 00:00:00

  • Neurosensory assessments of migraine.

    abstract::Headache medicine is primarily dependent on patients' subjective reports of pain, which are assessed at diagnosis and throughout the duration of treatment. There is a need for an objective, quantitative biological measurement of headache pain severity. In this study, quantitative sensory testing (QST) was conducted vi...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2012.12.043

    authors: Nguyen RH,Ford S,Calhoun AH,Holden JK,Gracely RH,Tommerdahl M

    更新日期:2013-03-01 00:00:00

  • Involvement of nitric oxide in the induction of interleukin-1 beta in microglia.

    abstract::In response to in vitro stimulation with lipopolysaccharide (LPS), microglia induce the production of the inflammatory cytokine interleukin-1 beta (IL-1β) together with nitric oxide (NO) and superoxide anion (O2(-)). Here we investigated the role of NO and O2(-) in the signaling mechanism by which IL-1β is induced in ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2015.08.030

    authors: Sudo K,Takezawa Y,Kohsaka S,Nakajima K

    更新日期:2015-11-02 00:00:00

  • Connectivities of the striatal grafts in adult rat brain: a rich afference and scant striatonigral efference.

    abstract::Previous reports from this laboratory have indicated that fetal rat striatal grafts have the major types of neuronal and glial components known to be involved in Huntington's chorea. In this study a number of major afferent and efferent innervations seen in normal striatum were examined in the striatal grafts and were...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)91592-8

    authors: Zhou FC,Buchwald N

    更新日期:1989-12-11 00:00:00

  • Spinal projections of renal afferent nerves in the rat.

    abstract::This study was designed to describe renal afferent information with respect to its intraspinal projections, convergence with cutaneous inputs, ascending projections, and modulation by descending fiber tracts. Extracellular recordings were made from neurons in the spinal gray while electrically stimulating the renal ne...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)91292-9

    authors: Knuepfer MM,Akeyson EW,Schramm LP

    更新日期:1988-04-12 00:00:00

  • Effects of continuous hypoxia on energy metabolism in cultured cerebro-cortical neurons.

    abstract::Mechanisms underlying hypoxia-induced neuronal adaptation have not been fully elucidated. In the present study we investigated glucose metabolism and the activities of glycolytic and TCA cycle enzymes in cerebro-cortical neurons exposed to hypoxia (3 days in 1% of O2) or normoxia (room air). Hypoxia led to increased a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2008.06.074

    authors: Malthankar-Phatak GH,Patel AB,Xia Y,Hong S,Chowdhury GM,Behar KL,Orina IA,Lai JC

    更新日期:2008-09-10 00:00:00

  • Temporal assessment of caspase activation in experimental models of focal and global ischemia.

    abstract::Rodent models of focal and global ischemia were used to examine caspase activation. Several readouts were employed on identical tissue to provide correlative measurement of caspase induction, activation and enzymatic activity. In a rat focal ischemia model, caspase-3 enzymatic activity, as recorded by DEVD-AMC cleavag...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(03)02846-4

    authors: Cho S,Liu D,Gonzales C,Zaleska MM,Wood A

    更新日期:2003-08-29 00:00:00

  • Central projections of the normal and 'regenerate' infraorbital nerve in adult rats subjected to neonatal unilateral infraorbital lesions: a transganglionic horseradish peroxidase study.

    abstract::Application of horseradish peroxidase (HRP) to the proximal stump of the transected infraorbital (IO) nerve in the orbit was employed in normal adult rats to demonstrate the ganglionic representation of and brainstem innervation by the trigeminal (V) branch which supplies primarily the mystacial vibrissae. In the V ga...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)90970-8

    authors: Jacquin MF,Rhoades RW

    更新日期:1983-06-13 00:00:00

  • Trimetazidine prevents cochlear lesions induced by intraperitoneal and perilymphatic administration of kainic acid.

    abstract::The protective activity of trimetazidine (TMZ) against cochlear neurotoxicity induced by intraperitoneal and intracochlear administration of kainic acid (KA) has been analyzed. The amplitude of the CAP N1 wave was significantly higher in KA rats pretreated with TMZ, independently of the administration route, than in t...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)01258-5

    authors: Gil-Loyzaga P,Hernández E,Carricondo F,Simón F,Poch-Broto J

    更新日期:1999-04-24 00:00:00

  • gamma-Aminobutyric acid (GABA) immunoreactivity in mouse and rat first somatosensory (SI) cortex: description and comparison.

    abstract::The location and morphological characteristics of gamma-aminobutyric acid (GABA)-immunopositive cells and their processes were studied in rat and mouse first somatosensory (SI) cortex (including 'barrels') in layer IV, and layers above (I-III), and below (V and VI). In coronal sections of SI cortex of both species GAB...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)91472-2

    authors: Chmielowska J,Stewart MG,Bourne RC

    更新日期:1988-01-26 00:00:00