Method of administration determines the effect of naloxone on pain.

abstract：:It has been hypothesised that the increased life span commonly observed in rodents that have had their diet restricted after weaning may be related to its effects on the anti-oxidant defence systems. However, undernutrition during the gestation and pre-weaning period is known to have long-term deleterious effects on a...

journal_title：Brain research

authors： Partadiredja G,Worrall S,Simpson R,Bedi KS

更新日期：2008-07-30 00:00:00

abstract：:Glial cell line derived neurotrophic factor (GDNF) is a potent survival factor for several types of neurons. GDNF binds with high affinity to GDNF-family receptor alpha-1 (GFR alpha-1). This receptor is expressed in different areas of the brain, including the hippocampus and dentate gyrus. By using in situ hybridizati...

journal_title：Brain research

authors： Sarabi A,Hoffer BJ,Olson L,Morales M

更新日期：2000-09-22 00:00:00

abstract：:The pars externa (PE) system of the anterior olfactory nucleus (AON) in a primate, Callithrix jacchus, was defined by its architecture and by its connection patterns with the main olfactory bulb (MOB) as revealed by tracing techniques. Focal, unilateral injections of wheat germ agglutinin-conjugated horseradish peroxi...

journal_title：Brain research

authors： Reyher CK

更新日期：1988-08-02 00:00:00

abstract：:Microinjection of apomorphine into the ventral tegmental area (VTA) of male rats was previously shown to delay the onset of copulation and slow its rate, presumably by stimulating impulse-regulating autoreceptors on cell bodies of the A10 mesocorticolimbic dopamine tract. Such stimulation would be expected to slow the...

journal_title：Brain research

authors： Hull EM,Weber MS,Eaton RC,Dua R,Markowski VP,Lumley L,Moses J

更新日期：1991-07-19 00:00:00

abstract：:Recent studies have confirmed the presence of insulin receptors in the rat brain although their function has still not been well defined. The present study explores the possibility that insulin receptors in the brain can alter or contribute to central neurotransmission. Insulin caused a dose-dependent inhibition of hi...

journal_title：Brain research

authors： Palovcik RA,Phillips MI,Kappy MS,Raizada MK

更新日期：1984-08-20 00:00:00

abstract：:A novel gold phosphate complex called Black-Gold II with improved myelin staining properties has been developed. It differs from its predecessor, Black-Gold, in that it is highly water soluble at room temperature. This unique physical property confers a number of advantages for the high resolution staining of myelinat...

journal_title：Brain research

authors： Schmued L,Bowyer J,Cozart M,Heard D,Binienda Z,Paule M

更新日期：2008-09-10 00:00:00

abstract：:The binding of the selective alpha 2-adrenoceptor antagonist radioligand [3H]rauwolscine ([3H]RAUW) to homogenates of cat frontal cerebral cortex and cat lumbar spinal cord was investigated. Experiments were performed at 20 degrees C in 50 mM Tris HCl/l mM Na2EDTA buffer (pH 6.9 at 20 degrees C). At this temperature, ...

journal_title：Brain research

authors： Howe JR,Yaksh TL

更新日期：1986-03-12 00:00:00

abstract：:Fetal exposure to dexamethasone (DEX) alters brain plasticity and cognitive functions during adulthood in a sex-dependent manner. The mechanisms underlying such long-lasting sex-dependent change of prenatal DEX is not well understood. The p73 gene plays an important role in brain development. It encodes for two protei...

journal_title：Brain research

authors： Abul M,Al-Bader MD,Mouihate A

更新日期：2019-03-15 00:00:00

abstract：:Rats with electrodes in either the posterior medial forebrain bundle (MFB), the anterior MFB, the medial prefrontal cortex, or the locus coeruleus self-stimulated during a 45 min period following the injection of [14C]2-deoxyglucose. They were then sacrificed and their brains prepared for autoradiography. The autoradi...

journal_title：Brain research

authors： Yadin E,Guarini V,Gallistel CR

更新日期：1983-04-25 00:00:00

abstract：:The myelin vacuolation (mv) rat exhibits hypomyelination and vacuole formation in the myelin throughout the CNS, caused by a null mutation in the attractin gene. Myelin alterations in the spinal cord of mv rats progress during postnatal development and are more prominent in the white matter. In contrast, microglial ac...

journal_title：Brain research

authors： Izawa T,Yamate J,Franklin RJ,Kuwamura M

更新日期：2010-02-02 00:00:00

abstract：:An experiment was performed in order to determine the role of the amygdala and surrounding cortex in quiet biting attack elicited from electrical stimulation of the hypothalamus. Stimulation of basal, cortical, and anterior amygdala as well as pyriform cortex and parahippocampal gyrus resulted in a suppression of the ...

journal_title：Brain research

authors： Block CH,Siegel A,Edinger H

更新日期：1980-09-15 00:00:00

abstract：:The newly identified neuropeptide nociceptin/orphanin FQ (NOC) was measured in different rat brain areas related to the descending anti-nociceptive pathways and compared to two opioid peptides, dynorphin B (DYN B) and Met-enkephalinArgPhe (MEAP). Two experimental models of chronic nociception, one neurogenic and one i...

journal_title：Brain research

authors： Rosén A,Lundeberg T,Bytner B,Nylander I

更新日期：2000-02-28 00:00:00

abstract：:The effects of target and non-target cells on the growth and function of intrastriatal grafts of mesencephalic dopamine neurons have been studied in rats with unilateral 6-hydroxydopamine-induced lesions of the nigrostriatal dopamine pathway. Cell suspensions of ventral mesencephalon from 14-15-day-old rat fetuses (ri...

journal_title：Brain research

authors： Brundin P,Isacson O,Gage FH,Björklund A

更新日期：1986-01-01 00:00:00

abstract：:Extracellular recording was used to investigate spontaneously active neurons in all four major nuclei of the rat vestibular nuclear complex (VNC) in brainstem slices. The density of spontaneously active neurons was highest in the medial vestibular nucleus (MVN), slightly lower in the superior (SuVN) and spinal (SpVN) ...

journal_title：Brain research

authors： Sun Y,Waller HJ,Godfrey DA,Rubin AM

更新日期：2002-04-26 00:00:00

abstract：:Here we describe a sustained outward potassium current (IK) in retinal horizontal cells (HCs). IK is unusually small over the range of membrane potentials normally experienced by these cells, which are chronically depolarized. We hypothesize that this unique IK will reduce the amount of neurotransmitter required to sh...

journal_title：Brain research

authors： Sullivan JM,Lasater EM

更新日期：1990-09-24 00:00:00

abstract：:A modified glyoxylic acid technique was used to examine central and peripheral nervous tissues in Aplysia californica. In addition to confirming the distribution of catecholamines and serotonin in the central nervous system, the method demonstrated the presence of monoamines in the opaline gland and bag cell clusters ...

journal_title：Brain research

authors： Tritt SH,Lowe IP,Byrne JH

更新日期：1983-01-17 00:00:00

abstract：:The mammalian circadian clock in the suprachiasmatic nuclei (SCN) can be phase-shifted in vitro by the serotonin agonist quipazine. Here we show that quipazine resets the SCN clock in the presence of tetrodotoxin or 10 mM Mg2+, treatments that block Na+ action potentials and Ca2+ channels, respectively. These results ...

journal_title：Brain research

authors： Prosser RA,Heller HC,Miller JD

更新日期：1992-02-28 00:00:00

abstract：:The N-methyl-d-aspartate (NMDA) receptor, a glutamate receptor subtype, is a ligand-gated ion channel. Overstimulation of NMDA receptors may increase intracellular Ca2+ concentrations to lethal levels in neurodegenerative disorders affecting the basal ganglia. Such excitotoxicity may also contribute to the loss of med...

journal_title：Brain research

authors： Hopkins KJ,Oster-Granite ML

更新日期：1998-06-29 00:00:00

abstract：:The effects of acute and chronic phencyclidine (PCP) administration on neurotensin-like immunoreactivity (NTLI) were investigated in discrete regions of rat brain. Both acute and chronic administration of PCP induced high locomotor activity, stereotypy and ataxia. On PCP administration, NTLI decreased significantly in...

journal_title：Brain research

authors： Wachi M,Okuda M,Togashi S,Fuwano S,Miyashita O

更新日期：1985-05-06 00:00:00

abstract：:Diabetes mellitus can lead to functional and structural deficits in both the peripheral and central nervous system. The pathogenesis of these deficits is multifactorial, probably involving, among others, microvascular dysfunction and alterations in intracellular calcium homeostasis. The present study examined the effe...

journal_title：Brain research

authors： Biessels GJ,ter Laak MP,Kamal A,Gispen WH

更新日期：2005-02-21 00:00:00

abstract：:The immunocytochemical localization of the enzyme choline acetyltransferase (ChAT) was examined in the guinea pig organ of Corti to determine if both lateral and medial systems of efferents would show immunoreactive labeling for this specific enzyme marker of cholinergic neurons. Cochleae were also examined after lesi...

journal_title：Brain research

authors： Altschuler RA,Kachar B,Rubio JA,Parakkal MH,Fex J

更新日期：1985-07-08 00:00:00

abstract：:Oligodendrocyte precursor cells (OPCs) react rapidly to brain and spinal cord injuries. This reaction is characterized by the retraction of cell processes, cell body swelling and increased expression of the NG2 chondroitin sulfate proteoglycan. Reactive OPCs rapidly divide and accumulate surrounding the injury site wh...

journal_title：Brain research

authors： Levine J

更新日期：2016-05-01 00:00:00

abstract：:Chronic neuropathic pain has demonstrated that coexisting psychiatric disorders are associated with disability and poorer treatment outcomes. Hyperpolarization-activated cyclic nucleotide-gated (HCN, Ih) channels play a major role in pain via hyperexcitability and facilitation of ectopic firing in neurons. Neuronal hy...

journal_title：Brain research

authors： Yang L,Liu X,Yao K,Sun Y,Jiang F,Yan H,Mao P,Fan S,Wei X,Liu Y,Yuan W,Zhang S

更新日期：2019-08-15 00:00:00

abstract：:The nonsteroidal anti-inflammatory drugs are presumed to produce their analgesic effects by inhibiting the cyclooxygenase catalyzed metabolism of arachidonic acid to hyperalgesic prostanoids. This study examined the hyperalgesic effect of a range of prostaglandins. We found, employing the rat paw-withdrawal test, that...

journal_title：Brain research

authors： Taiwo YO,Levine JD

更新日期：1990-12-24 00:00:00

abstract：:The distribution of fast axonally transported proteins was studied by electron microscope radioautography in ciliary ganglia of chickens treated or not treated with acrylamide. At 3 h after the intracerebral injection of [3H]lysine, the preganglionic axons of the untreated chickens displayed few silver grains, mainly ...

journal_title：Brain research

authors： Chretien M,Patey G,Souyri F,Droz B

更新日期：1981-01-26 00:00:00

abstract：:In the present study, we investigated the co-localization pattern of the delta subunit with other subunits of GABA(A) receptors in the rat brain using immunoprecipitation and Western blotting techniques. Furthermore, we investigated whether low concentrations of ethanol affect the delta-subunit-containing GABA(A) rece...

journal_title：Brain research

authors： Mehta AK,Marutha Ravindran CR,Ticku MK

更新日期：2007-08-24 00:00:00

abstract：:The contribution of opioid receptors in the nucleus accumbens to contextual and auditory fear conditioning was examined. Impairment in contextual fear conditioning was found when training occurred under accumbal infusions of the opioid receptor agonist morphine in a dose-dependent and receptor specific fashion, only w...

journal_title：Brain research

authors： Iordanova MD,Haralambous T,McNally GP,Westbrook RF

更新日期：2013-06-23 00:00:00

abstract：:In terrestrial gastropod mollusks (slugs and snails), olfaction is the dominant sensory modality guiding various kinds of behavior. Anatomical studies indicate that olfactory information is processed in the brain (the cerebral ganglion) in two lobes in particular: the procerebrum (PC) and the metacerebrum (MtC). This ...

journal_title：Brain research

authors： Makinae H,Makino Y,Obara T,Yano M

更新日期：2008-09-22 00:00:00

abstract：:Although Rolling mouse Nagoya (RMN) has been considered to demonstrate cerebellar dysfunction, our previous metabolic and electrophysiological studies also revealed a dysfunction of the basal ganglia, with the presumable primary site of dysfunction being the striatum. In the present study, we investigated the neuroche...

journal_title：Brain research

authors： Taniwaki T,Shinoda H,Kaseda Y,Kato M,Goto I

更新日期：1996-04-01 00:00:00

abstract：:We have investigated, in 9 normal subjects, the time course of amplitude changes in the automatic long latency stretch reflex of wrist flexors during the preparatory period as a function of the precued direction of hand movement. Subjects maintained right hand position against a weak force and learned to compensate pr...

journal_title：Brain research

authors： Bonnet M

更新日期：1983-11-28 00:00:00