Abstract：
:Six cats were trained to eat while partially restrained and while thermal pulse stimuli (43-60 degrees C, 5 s duration) were delivered to the upper hindlimbs. Food and stimulus delivery were under programmed electronic control. The probability and latency of 3 natural, unlearned nocifensive behaviors were electronically registered: interruption of eating or of exploring for food, hindlimb movement and vocalization. Preoperatively, all cats showed significant increases in the probability of two or more behaviors as stimulus temperature increased. Each cat also showed a significant food-induced suppression of one or more of these behaviors. Thermocoagulation lesions limited to the giganto- and magnocellular fields of the medial medullary reticular formation (4 cats) produced a decrease in nocifensive responsiveness. Larger lesions within the same area but with extension into the postpyramidal raphe nuclei, resulted in increased nocifensive responsiveness (2 cats). No lesion affected response latency or the food-induced modulation of nocifensive behavior. The results support the hypothesis that supraspinally organized nocifensive responses are: (1) tonically facilitated by neural activity originating in or passing through the medial bulboreticular formation; (2) tonically suppressed by midline raphe spinal neurons; and (3) phasically modulated by suprabulbar neural mechanisms that are related to changes in behavioral state.
journal_name
Brain Resjournal_title
Brain researchauthors
Casey KL,Morrow TJdoi
10.1016/0006-8993(89)91036-6subject
Has Abstractpub_date
1989-10-30 00:00:00pages
150-61issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(89)91036-6journal_volume
501pub_type
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