Abstract：
:Intoxication with organophosphorus (0P) anticholinesterase agents such as soman triggers irreversible lesions in some cerebral areas. Administration of soman at the LD 50 leads to an increased activity of NADPH-diaphorase (= NO-synthase) in the cerebral endothelial cells from the 6th hour after poisoning. This activity culminates after 24 h, whereas variations in this enzymatic activity are not easily detectable in NADPH-diaphorase positive neurons. Since soman triggers astrocytic oedema leading to a possible decrease in the local cerebral blood flow, it is likely that the induction of endothelial NO-synthase exerts an antagonistic effect, since NO is a vasodilator.
journal_name
Brain Resjournal_title
Brain researchauthors
Bouchaud C,Chollat-Namy A,Duserre S,Delamanche ISdoi
10.1016/0006-8993(94)91296-3subject
Has Abstractpub_date
1994-10-17 00:00:00pages
249-54issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(94)91296-3journal_volume
660pub_type
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