Abstract：
:Maternal melatonin readily crosses the placenta to provide the fetus with time-of-day and day length information. To determine if melatonin could have a broader role during development than is currently recognized, melatonin receptor expression was examined in somatic sites during Siberian hamster embryogenesis. Using 125I-labeled-2-iodomelatonin ([125I]MEL), melatonin receptor expression was examined in whole fetuses by in vitro autoradiography. [125I]MEL binding sites were first apparent at gestational day (GD) 10 over the primitive oral pharynx. From GD 12 to 14, binding was present over the nasal pharynx, Rathke's pouch, caudal arteries, and over the thyroid gland during its migration along the thyroglossal duct. By GD 16, Rathke's pouch had differentiated into the pituitary gland, which continued to express specific [125I]MEL binding until birth. From GD 16 until birth, binding was no longer detectable over the thyroid gland, but persisted over the nasal epithelium. At all ages, binding sites exhibited high affinity for [125I]MEL and appeared to be coupled with guanosine nucleotide-binding proteins. These data suggest that melatonin receptors are expressed in several somatic sites, including Rathke's pouch and the thyroid gland, during fetal development.
journal_name
Brain Resjournal_title
Brain researchauthors
Rivkees SA,Reppert SMdoi
10.1016/0006-8993(91)91424-ysubject
Has Abstractpub_date
1991-12-24 00:00:00pages
345-9issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(91)91424-Yjournal_volume
568pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Transport of the hexapeptide dalargin across the blood-brain barrier was accomplished using a nanoparticle formulation. The formulation consisted of dalargin bound to poly(butyl cyanoacrylate) nanoparticles by sorption, coated with polysorbate 80. Intravenous injection of this formulation to mice resulted in an analge...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00023-j
更新日期：1995-03-13 00:00:00
abstract：:Several studies have demonstrated that the blood-brain barrier (BBB) (dynamic cellular complex composed by brain capillary endothelial cells (BCECs) and surrounded by astrocytic end feet and pericytes) regulates the exchanges of amyloid β (Aβ) peptide between the blood and the brain. Deregulation of these exchanges se...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.10.047
更新日期：2015-01-12 00:00:00
abstract：:Alterations in brain high energy phosphate compounds, using 31P-NMR (nuclear magnetic resonance) spectroscopy, were measured in vivo in young adult (3-4 months) rats following prenatal exposure to ligands acting specifically at benzodiazepine (BDZ) binding sites. The exposure induced a decrease in intracellular pH tha...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91202-r
更新日期：1990-01-01 00:00:00
abstract：:Axonal projections of medial brain stem areas rich in serotonin-containing neurons were identified in layers I and II of cat medullary dorsal horn using EM autoradiography. Following [3H]amino acid injections into the brain stem, labeled axonal endings were found throughout layers I and II but were most numerous in la...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90729-0
更新日期：1981-01-26 00:00:00
abstract：:Using the passive avoidance learning task in rats, the role of brain somatostatin in cognitive function was investigated with special reference to that of the brain cholinergic system. In addition, the involvement of both the brain somatostatinergic and cholinergic systems in the anti-amnesic action of a newly introdu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90900-8
更新日期：1994-04-11 00:00:00
abstract：:We examined the in vitro effects of neurotransmitters, high KCl as well as sialic acid-containing compounds (GM1; SC) on transglutaminase (TG) activity in isolated superior cervical ganglia (SCG) one week after denervation or axotomy. Following denervation, TG activity in SCG decreased to 83% of the unoperated control...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90352-n
更新日期：1993-02-26 00:00:00
abstract：:Transgenic mice expressing human APPswe and PS1-A264E mutations mimic certain neuropathological features of Alzheimer's disease (AD). These mice have elevated levels of the highly fibrillogenic amyloid beta1-42 peptide (Abeta42) and develop amyloid plaques around the age of 9 months. Our aim was to find whether these ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02617-3
更新日期：2002-07-12 00:00:00
abstract：:Double impregnation staining of tissue was used to study on thick sections the three-dimensional configuration of the peripheral endoplasmic reticulum in neurosecretory neurons of the supraoptic nucleus in control and water-deprived rats. According to the spatial organization of the endoplasmic reticulum, two types of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90105-7
更新日期：1979-07-13 00:00:00
abstract：:Measurements of extracellular Ca2+ and K+ activities [( Ca2+]o, [K+]o) in the superfused cat carotid body in vitro with triple-barrelled ion-selective electrodes have shown that hypoxia induced a decrease in [Ca2+]o of 0.035 +/- 0.17 mM (mean +/- S.D.; n = 17) and a biphasic change in [K+]o which consisted of an incre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91186-4
更新日期：1989-03-20 00:00:00
abstract：:It has been accepted that the descending system from the nucleus locus coeruleus (LC)/nucleus subcoeruleus (SC) plays a significant role in spinal nociceptive processing. The present study was designed to examine modulation of nociceptive processing in the caudal part of the trigeminal sensory nuclear complex, the tri...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.09.023
更新日期：2003-12-12 00:00:00
abstract：:The relationship between fiber tract formation and transverse and longitudinal borders of the diencephalon was investigated in Alligator embryos beginning when this structure was a single unit and continuing until internal subgroups were present within individual segments. At all stages of development, distinct bundle...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.11.081
更新日期：2010-02-08 00:00:00
abstract：:Alterations in local cerebral glucose utilization (LCGU) induced by electrical stimulation of the sensory relay nucleus (VPL) or parafascicular nucleus (Pf) of the thalamus in conscious rats were measured by the [14C]2-deoxyglucose method, the objective being to assess the mechanism of analgesia induced by electrical ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90357-x
更新日期：1987-04-07 00:00:00
abstract：:Reduced neuronal plasticity in the striatum, hippocampus, and neocortex is a common feature of transgenic mouse models of Huntington's disease (HD). Doublecortin (DCX) and polysialylated neural cell adhesion molecule (PSA-NCAM) are associated with structural plasticity in the adult mammalian brain, are markers of newl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.03.018
更新日期：2007-06-02 00:00:00
abstract：:Erythropoietin (EPO), a hematopoietic hormonal cytokine induced in response to hypoxia, has neuroprotective effects. EPO receptor (EPOR) is expressed in microglia, resident immune cells in the brain. However, the effect of EPO on microglial activation is not clear. In the present study, we demonstrated that the EPOR i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.02.023
更新日期：2017-05-01 00:00:00
abstract：:Intraventricular administration of cholecystokinin-octapeptide in unanesthetized rats results in a significant reduction in the number of [3H]spiperone binding sites. Striatal levels of the dopamine metabolites 3,4-dihydroxyphenylacetic acid and homovanillic acid were significantly reduced, whereas there was no signif...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90949-6
更新日期：1983-10-31 00:00:00
abstract：:In the urethane-anesthetized rat both electrical stimulation (20 microA, 0.2 ms, 30 s) through micropipettes and glutamate injections (0.1 M, 100 nl) within an area including the dorsal lateral parabrachial nucleus, the adjacent central lateral parabrachial nucleus, the external lateral parabrachial nucleus, the Kölli...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90570-7
更新日期：1988-10-18 00:00:00
abstract：:(1)The brain stem of anaesthetized cats has been mapped between Horsley-Clark planes APO and P8.5 with electrical stimuli of low intensity in order to determine the areas which can produce excitatory of inhibitory influences on the spontaneously contracting, sympathetically denervated, urinary bladder. (2) Two inhibit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90865-4
更新日期：1982-02-25 00:00:00
abstract：:Rab3A is a small GTP-binding synaptic vesicle protein, shown to dissociate from synaptic vesicle membranes upon depolarization-induced exocytosis. Using an antiserum raised against rab3A, we found that the antigen was localized to the neuropil of specific brain regions, but was not present in major fiber tracts or mos...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91087-u
更新日期：1992-09-11 00:00:00
abstract：:An interaction between angiotensin II (Ang II) receptors and alpha 2-adrenoceptors was evaluated in the nucleus tractus solitarii (NTS) of the normotensive Wistar-Kyoto rat (WKY) and of the spontaneously hypertensive rat (SHR) using quantitative receptor autoradiography and cardiovascular analysis. In the WKY rat, Ang...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00220-k
更新日期：1995-05-08 00:00:00
abstract：:The effect of lowered brain glutathione content on the glutamate release following cerebral ischemia was investigated. Diethylmaleate (4 mmol/kg, i.p.), a commonly used chemical reagent for tissue glutathione depletion, significantly reduced the ischemia-induced glutamate release. The release of another excitatory ami...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00992-y
更新日期：1995-11-06 00:00:00
abstract：:Our previous study [32] indicated that blockade of kappa-opioid receptors with nor-binaltorphimine (nor-BNI) in the medial preoptic area (MPOA) produced two different LH responses during midpregnancy in the rat: an increase in basal pulsatile LH secretion, followed in many cases by a larger and/or sustained increase i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00874-p
更新日期：1995-11-06 00:00:00
abstract：:Previous electrophysiological as well as imaging research has contributed to the understanding of impairments in attention, executive functions, and memory in patients with attention-deficit/hyperactivity disorder (ADHD). However, there is a lack of studies investigating ADHD related differences in the gamma range of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.06.023
更新日期：2008-10-15 00:00:00
abstract：:Minor brain injury was inflicted with a small needle at 4 sites one week before the production of incomplete brain ischemia in the mouse. A bilateral carotid clamp was applied for 60 min under pentobarbital anesthesia, and the number of survivors at one week after the ischemic insult was compared with those in animals...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90091-0
更新日期：1986-09-03 00:00:00
abstract：:We studied seizures which were induced by a microinjection of kainic acid (KA) into the unilateral olfactory bulb (OB) in the rats. The first epileptiform discharge appeared in the OB, was then propagated to the amygdala and the hippocampus unilaterally, and finally propagated to the unilateral sensori-motor cortex. C...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00626-2
更新日期：1995-09-25 00:00:00
abstract：:A novel and convenient assay was used to determine the effect of recombinant Interleukin-2 (IL-2) on the function of the blood-brain barrier (BBB). The assay is based on a variant of the West Nile virus, WN-25, which had lost its neuroinvasiveness but not its neurovirulence. WN-25, when injected intravenously, can cau...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91079-2
更新日期：1989-09-04 00:00:00
abstract：:Chronic neuropathic pain has demonstrated that coexisting psychiatric disorders are associated with disability and poorer treatment outcomes. Hyperpolarization-activated cyclic nucleotide-gated (HCN, Ih) channels play a major role in pain via hyperexcitability and facilitation of ectopic firing in neurons. Neuronal hy...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.03.036
更新日期：2019-08-15 00:00:00
abstract：:Intraocular injections of tetrodotoxin were used to block activity for 27 days in normal fish and for the first 27 or 31 days of regeneration in fish with one optic nerve crushed. Synaptic activity was then assessed by a current source-density analysis of field potentials evoked by optic nerve shock at different times...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90958-7
更新日期：1983-06-13 00:00:00
abstract：:High salt intake is able to evoke neuroendocrine and autonomic responses that include vasopressin release and sympathoexcitation resulting in increasing in the arterial blood pressure (BP). The C1 neurons are a specific population of catecholaminergic neurons located in the RVLM region and they control BP under homeos...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.147107
更新日期：2020-12-01 00:00:00
abstract：:We assessed the chronological change of the expression of synaptophysin, an integral glycoprotein on the presynaptic vesicles, after a transient cerebral ischemic insult in the rat. The ischemic lesion was consistently localized in the dorsolateral part of the striatum, which was clearly visualized by a depletion of c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90225-c
更新日期：1993-07-09 00:00:00
abstract：:Serotonin (5-HT) produces both short- and long-term enhancement of generator potentials in identified type B-photoreceptors of Hermissenda. The actions of 5-HT have been shown to modulate both light- and voltage-dependent conductances. To further examine light-dependent processes we studied spontaneous and light-elici...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90969-t
更新日期：1993-11-19 00:00:00
