Motor function and dopamine release measurements in transgenic Huntington's disease model rats.

abstract：:Neurotrophic factors (NTFs), beside regulating neuronal survival in the central and peripheral nervous system, are also involved in the modulation of neuronal function in the adult animal. Both brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor (GDNF) levels are altered in pathological...

journal_title：Brain research

authors： Ciobanu C,Reid G,Babes A

更新日期：2009-08-11 00:00:00

abstract：:The function of the phosphoinositide signal transduction system and the levels of heterotrimeric G-protein alpha-subunits were examined in postmortem prefrontal cortex regions (8/9) and region (10) from suicide victims with major depression and matched control subjects without psychiatric illness. The hydrolysis of [3...

journal_title：Brain research

authors： Pacheco MA,Stockmeier C,Meltzer HY,Overholser JC,Dilley GE,Jope RS

更新日期：1996-06-03 00:00:00

abstract：:The subfornical organ, along with other regions of the lamina terminalis, may contain osmoreceptors and is likely to be a site of action of blood-borne angiotensin II. The neural pathways by which these stimuli lead to vasopressin secretion, have been suggested to extend from the subfornical organ to hypothalamic site...

journal_title：Brain research

authors： Oldfield BJ,Hards DK,McKinley MJ

更新日期：1991-08-30 00:00:00

abstract：:To date several circuities in supraspinal site of the central nervous system have been known to engage in pain modulation. Lateral hypothalamus (LH) is known as part of the circuit of pain modulation among supraspinal sites. Its role in several animal pain models has been well defined. In this study, we examined the r...

journal_title：Brain research

authors： Salehi S,Kashfi K,Manaheji H,Haghparast A

更新日期：2020-04-01 00:00:00

abstract：:Previous studies have shown that pyramidal neurons in hippocampal regions CA1 and CA3 are selectively vulnerable in several neurodegenerative disorders and that a subpopulation of pyramidal neurons in cell cultures of embryonic hippocampus are sensitive to glutamate neurotoxicity. In order to determine whether the pat...

journal_title：Brain research

authors： Mattson MP,Kater SB

更新日期：1989-06-19 00:00:00

abstract：:To determine whether the idiosyncratic distribution of transduction mechanisms for bitter tastants in rat taste receptor cells (TRCs) could be inferred from the neural activity they evoke, single neuron responses to ten bitter-tasting compounds were recorded from rat glossopharyngeal (n = 30) and chorda tympani (n = 2...

journal_title：Brain research

authors： Dahl M,Erickson RP,Simon SA

更新日期：1997-05-09 00:00:00

abstract：:The effect of excitatory amino acid antagonists on antagonist on neuropeptide Y (NPY) and cholinergic neurons in the striatum of the rat was studied by means of NPY immunocytochemistry, DFP histochemistry for acetylcholinesterase (AChE), and biochemical determinations of choline acetyltransferase (ChAT). Intrastriatal...

journal_title：Brain research

authors： Boegman RJ,Parent A

更新日期：1988-06-14 00:00:00

abstract：:Rab3A is a synaptic vesicle-associated GTP-binding protein thought to be involved in modulation of presynaptic transmitter release through regulation of vesicle trafficking and membrane fusion. Electrophysiological studies at central nervous system synapses of Rab3A null-mutant mice have indicated that nerve stimulati...

journal_title：Brain research

authors： Sons MS,Plomp JJ

更新日期：2006-05-17 00:00:00

abstract：:We have previously shown that hypothyroidism produces a decrease in the number of spines counted along the apical shafts of pyramidal neurons of the cortex. Nevertheless, other authors have found that when an animal is subjected to some adverse living conditions the size of the spines decreases, making them invisible ...

journal_title：Brain research

authors： Berbel PJ,Escobar del Rey F,Morreale de Escobar G,Ruiz-Marcos A

更新日期：1985-07-01 00:00:00

abstract：:Extracellular single-unit activity was recorded from neurons of the internal and external pallidal segments, and from 'border cells' at the periphery of the segments, in 3 waking cynomolgus monkeys during electrical stimulation of 3 sites bilaterally in the striatum: one in the caudate nucleus and two in the putamen. ...

journal_title：Brain research

authors： Tremblay L,Filion M

更新日期：1989-09-25 00:00:00

abstract：:Previous research has demonstrated that feedback circuits such as reflexes can be tuned by setting their gains prior to movement onset during both posture and movement tasks. However, such a control strategy requires that perturbation contingencies be predicted during movement planning and that task goals remain fixed...

journal_title：Brain research

authors： Mutha PK,Boulinguez P,Sainburg RL

更新日期：2008-12-30 00:00:00

abstract：:mRNA prepared from rat small intestine was injected into Xenopus oocytes. The injected oocytes showed a clear electrical response to D-glucose (Glu) in the form of membrane depolarization and conductance increase, while none was shown to D-fructose. The membrane electrical response of the injected oocytes evoked by Gl...

journal_title：Brain research

authors： Aoshima H,Ishii H,Anan M

更新日期：1987-09-01 00:00:00

abstract：:The effect of aminoguanidine (AG) on structural abnormalities in optic nerve fibers was evaluated in streptozotocin-induced diabetic rats. Morphometry of myelinated optic nerve fibers showed a partial amelioration on the reduction of the axon size but complete preservation of myelin size with low dose (25 mg kg-1 body...

journal_title：Brain research

authors： Ino-ue M,Ohgiya N,Yamamoto M

更新日期：1998-08-03 00:00:00

abstract：:The patch-clamp technique was used to characterize the single channel ion currents in primary cultures of rat astrocytes. The most dominant channel type, which was found in over half of the inside-out membrane patches, was a potassium channel. The measured reversal potential was -67 mV, which is close to the calculate...

journal_title：Brain research

authors： Jalonen T,Holopainen I

更新日期：1989-04-10 00:00:00

abstract：:The lamprey brainstem contains a 'command system' which descends into the spinal cord to activate motor networks and initiate locomotion. In the present study, partial lesions were made in the rostral spinal cord in order to spare various tracts and determine which tracts carry the descending command signal to the spi...

journal_title：Brain research

authors： McClellan AD

更新日期：1988-08-09 00:00:00

abstract：:Prostanoids in the central nervous system define an important linkage between blood pressure and hormonal responses to hypotension/ischemia. Prostaglandin endoperoxide synthase (PGHS)-2, the inducible isoform of this enzyme, is induced by cerebral hypoperfusion/ischemia. To investigate the mechanism of the PGHS-2 gene...

journal_title：Brain research

authors： Zhang D,Wood CE

更新日期：2005-10-26 00:00:00

abstract：:Thresholds of induction of heat shock protein (HSP) 70 and heat shock cognate protein (HSC) 70 mRNAs after transient global ischemia in gerbil brain were investigated by in situ hybridization using cloned cDNA probes selective for each mRNA species. In sham control brain, HSP70 mRNA was little present, while HSC70 mRN...

journal_title：Brain research

authors： Kawagoe J,Abe K,Kogure K

更新日期：1992-12-25 00:00:00

abstract：:Insulin has emerged as an important neuropeptide. Central actions of insulin appear to oppose those in the periphery. Insulin is transported across the blood-brain barrier (BBB) by a saturable transport system. The permeability of the BBB to insulin is altered by various events, but no studies exist that have examined...

journal_title：Brain research

authors： Xaio H,Banks WA,Niehoff ML,Morley JE

更新日期：2001-03-30 00:00:00

abstract：:The projections of putative dopamine containing cells within the dorsal raphe nucleus (DR) were studied using a combination of tyrosine hydroxylase (TH) immunocytochemistry and fluorescent retrograde tracing. Substantial numbers of TH-immunoreactive cells in the DR were found to project to the nucleus accumbens. Progr...

journal_title：Brain research

authors： Stratford TR,Wirtshafter D

更新日期：1990-03-12 00:00:00

abstract：:Corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) are pivotal mediators of the hormonal response to stressors and are found within neurons of the paraventricular nucleus of the hypothalamus (PVN) and several extrahypothalamic sites where expression is activity-dependent. Previous work has shown incr...

journal_title：Brain research

authors： Foradori CD,Lund TD,Nagahara AH,Koenig JI,Handa RJ

更新日期：2007-08-20 00:00:00

abstract：:Knowledge of the effects of nerve growth factor (NGF) on glia is limited. A CNS site where NGF-glial interactions may occur is the retina. NGF is endogenous to the retina, and the retinal Müller glial cells have NGF receptors. Here, we examined the possibility that NGF may be a mitogen for Müller glial cells, which of...

journal_title：Brain research

authors： Ikeda T,Puro DG

更新日期：1994-06-27 00:00:00

abstract：:The organization of the wing component of the dorsal column-medial lemniscal pathway, and somatosensory projections from the thalamus to the Wulst, are described for an oscine member of the major group of birds, the Passeriformes. Wing primary afferents terminate throughout the cervical spinal cord, but between the br...

journal_title：Brain research

authors： Wild JM

更新日期：1997-06-06 00:00:00

abstract：:By use of the push-pull perfusion technique, release of neuronal cholecystokinin-like immunoreactivity (CCK-LI) from hypothalamus of owl monkeys was investigated in relation to an intragastric meal. In overnight fasted, halothane-anesthetized owl monkeys, levels of CCK-LI in the hypothalamic push-pull perfusate were b...

journal_title：Brain research

authors： Schick RR,Reilly WM,Roddy DR,Yaksh TL,Go VL

更新日期：1987-08-18 00:00:00

abstract：:Intrathecal administration of alpha(2) adrenergic agonists, such as clonidine, is capable of alleviating neuropathic pain. Recent studies suggest that spinal nitric oxide (NO) mediates the analgesic effect of intrathecal clonidine. Furthermore, compared to nicotinic receptors, spinal muscarinic receptors play a greate...

journal_title：Brain research

authors： Xu Z,Chen SR,Eisenach J,Pan HL

更新日期：2000-04-10 00:00:00

abstract：:We sought to determine whether the global increase in regional cerebral blood flow (rCBF) produced by electrical stimulation of the rostral cerebellar fastigial nucleus (FN) is a consequence of excitation of intrinsic neurons of the FN or of axons of fibers passing through or projecting into it. Studies were conducted...

journal_title：Brain research

authors： Chida K,Iadecola C,Reis DJ

更新日期：1989-10-23 00:00:00

abstract：:Female rats were subjected to unilateral left or right, bilateral, or sham ablation of the cerebral cortex. Eight weeks after surgery, the rats were sacrificed by decapitation and spleen cells were grown in culture for 96 h in the presence or absence of the T-cell mitogen concanavalin A or the B-cell mitogen lipopolys...

journal_title：Brain research

authors： LaHoste GJ,Neveu PJ,Mormède P,Le Moal M

更新日期：1989-03-27 00:00:00

abstract：:We sought to identify the areas that have altered neuronal activity within the hypothalamus of rats with heart failure (HF) by mapping neuronal staining of c-Fos protein (Fos) 6-8 weeks following coronary artery ligation (HF group; n=17) or sham surgery (sham-operated control group, n=15). Fos-like immunoreactivity wa...

journal_title：Brain research

authors： Patel KP,Zhang K,Kenney MJ,Weiss M,Mayhan WG

更新日期：2000-05-19 00:00:00

abstract：:The benzomorphan sigma ligands, (+)-N-allylnormetazocine (NANM) and (+)-pentazocine, but not (+)-cyclazocine, stereospecifically stimulated dopamine synthesis in minces of rat corpus striatum by 15-23% over basal values at 0.1-1.0 microM. The effect of (+)-NANM and (+)-pentazocine was blocked by the reported sigma ant...

journal_title：Brain research

authors： Booth RG,Baldessarini RJ

更新日期：1991-08-23 00:00:00

abstract：:The role of the cerebellum and the red nucleus in the conditioned eyeblink response was assessed, using a combination of reversible lesions and multiple-unit extracellular recording in the awake, behaving rabbit. Lesion, recording, and stimulation experiments have indicated that both of these structures are involved i...

journal_title：Brain research

authors： Chapman PF,Steinmetz JE,Sears LL,Thompson RF

更新日期：1990-12-24 00:00:00

abstract：:Intracranial microdialysis was used to measure dopamine (DA) release in the ventrolateral neostriatum of freely moving rats before and after unilateral tactile stimulation was applied to the orofacial region. Several behavioral parameters which have been linked to changes in nigrostriatal DA transmission (scanning, or...

journal_title：Brain research

authors： Adams F,Schwarting RK,Boix F,Huston JP

更新日期：1991-07-12 00:00:00