Abstract：
:Intracranial microdialysis was used to measure dopamine (DA) release in the ventrolateral neostriatum of freely moving rats before and after unilateral tactile stimulation was applied to the orofacial region. Several behavioral parameters which have been linked to changes in nigrostriatal DA transmission (scanning, or snout contact with the walls of the observation chamber, turning and locomotion) were measured as well. Orofacial stimulation was followed by an asymmetrical increase in DA release with concentrations of transmitter higher in the neostriatum ipsilateral to the side of stimulation. Asymmetrical scanning behavior was observed during the time period when DA release was asymmetric, with rats favoring use of the side of the face contralateral to increased DA release. Increases in the DA metabolites DOPAC and HVA were found in the striatum ipsilateral to stimulation, but were delayed 40 min following the increase in DA.
journal_name
Brain Resjournal_title
Brain researchauthors
Adams F,Schwarting RK,Boix F,Huston JPdoi
10.1016/0006-8993(91)90842-jsubject
Has Abstractpub_date
1991-07-12 00:00:00pages
318-22issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(91)90842-Jjournal_volume
553pub_type
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