Abstract：
:An extensive behavioral characterization was conducted with mice lacking the gene for neuropeptide Y (NPY) including response to 24 and 48 h fast and challenge with small molecule antagonists of NPY receptors implicated in mediating the feeding effects of NPY (i.e., Y1 and Y5). In addition, wildtype (WT) and NPY knockout (KO) mice were tested in locomotor monitors, elevated plus maze, inhibitory avoidance, acoustic startle, prepulse inhibition, and hot plate assays. One of the major findings was that the NPY KO mice have a reduced food intake relative to WT controls in response to fasting. Also, based on data from the behavioral models, the NPY KO mice may have an anxiogenic-like phenotype, and appear to be hypoalgesic in the hot plate paradigm. The data from these studies provide further evidence of involvement of NPY in energy balance, anxiety, and possibly nociception.
journal_name
Brain Resjournal_title
Brain researchauthors
Bannon AW,Seda J,Carmouche M,Francis JM,Norman MH,Karbon B,McCaleb MLdoi
10.1016/s0006-8993(00)02285-xsubject
Has Abstractpub_date
2000-06-16 00:00:00pages
79-87issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(00)02285-Xjournal_volume
868pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Met-enkephalin immunoreactive material content was found to be decreased in the cervical and thoracic segments of the spinal cord from rats aged 25 months as compared to young, 3-month-old, rats. No age-related variations were detectable at the lumbar level. Bio-Gel P 30 column chromatography of thoracic segment extra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90481-x
更新日期：1983-02-28 00:00:00
abstract：:Microarray analysis has been used to understand how gene regulation plays a critical role in neuronal injury, survival and repair following ischemic stroke. To identify the transcriptional regulatory elements responsible for ischemia-induced gene expression, we examined gene expression profiles of rat brains following...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.11.052
更新日期：2013-02-07 00:00:00
abstract：:Bilateral microinjections of the neuroleptic, cis-flupenthixol, were made into 56 forebrain targets distributed across various dopamine (DA) terminal fields in the forebrain. Drug effects on medial forebrain bundle (MFB) stimulation-produced reward were assessed with a rate-frequency procedure implemented in a runway ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91400-5
更新日期：1989-01-16 00:00:00
abstract：:Previous studies have revealed that there are increases in the incorporation of [3H]amino acids into protein in the denervated neuropil of the dentate gyrus during periods of reactive synaptogenesis. The present study evaluates whether the increase in incorporation reflects an increase in protein synthetic machinery (...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0169-328x(87)90032-5
更新日期：1987-09-01 00:00:00
abstract：:Fetal mouse retinal ganglion cell axons have been shown to ramify within co-cultured basement membrane secreting tumor explants and upon isolated basement membranes. Here we report that laminin, a glycoprotein found in basement membranes and adhesion sites of a variety of cell types, acted as a substrate for retinal e...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(84)90184-6
更新日期：1984-01-01 00:00:00
abstract：:The effect of MK-801 on striatal dopamine (DA) release was investigated by using an in vivo microdialysis technique in the freely moving rat. Systemic injection of MK-801 (0.25, 0.5, 1, 2 mg/kg, i.p.) reduced the extracellular level of DA significantly and produced no change in the level of 3,4-dihydroxyphenylacetic a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90197-j
更新日期：1990-09-24 00:00:00
abstract：:It was previously reported that chronic food restriction and maintenance of rats at 75-80% of initial body weight enhanced the reward-potentiating effect of D-amphetamine in the lateral hypothalamic self-stimulation (LHSS) paradigm. Moreover, the enhancement reversed in parallel with body weight recovery when ad libit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.03.002
更新日期：2006-05-04 00:00:00
abstract：:An intracerebral microdialysis technique was applied to study the effect of metabotropic glutamate receptor (mGluR) agonist on dopamine release in the striatum of methamphetamine (MAP)-sensitized rats. Rats were treated with MAP (1 mg/kg, i.p.) once daily for 6 consecutive days, followed by a 6-day withdrawal. Perfusi...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1996-08-12 00:00:00
abstract：:Microglial reactivity in the red nucleus of rats was studied following upper cervical and lower thoracic rubrospinal tractotomy using the lectin binding method. Following axotomy, the contralateral nucleus containing the axotomized neurons was identified using the retrograde tracer Fast blue. It was subdivided into do...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01418-7
更新日期：1996-04-09 00:00:00
abstract：:The understanding of sentences involves not only the retrieval of the meaning of single words, but the identification of the relation between a verb and its arguments. The way the brain manages to process word meaning and syntactic relations during language comprehension on-line still is a matter of debate. Here we re...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2006.08.038
更新日期：2007-05-18 00:00:00
abstract：:The present study was undertaken to investigate and compare the properties of noradrenaline release in the locus coeruleus (LC) and prefrontal cortex (PFC). For that aim the dual-probe microdialysis technique was applied for simultaneous detection of noradrenaline levels in the LC and PFC in conscious rats. Calcium om...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02553-7
更新日期：2001-07-06 00:00:00
abstract：:The dentato-olivary projection has been ultrastructurally studied in rats that received a wheatgerm agglutinin-horseradish peroxidase (WGA-HRP) injection in the nucleus lateralis. Ultrathin sections containing the inferior olive have been double-labelled with the GABA-immunogold method. About 97% of the WGA-HRP labell...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91641-7
更新日期：1989-02-13 00:00:00
abstract：:Past studies in the rat and Syrian hamster show that metabolic and electrical activity of the suprachiasmatic nuclei (SCN) is inhibited by melatonin (MEL) at about circadian time (ct) 8-11 h. The present experiment examined the effect of MEL on the firing frequency of SCN cells in brain slices prepared from long day (...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90853-f
更新日期：1993-04-23 00:00:00
abstract：:The effects of intracerebral injections of brain-gut peptides in the preoptic region on the secretion of luteinizing hormone (LH) and prolactin (PRL) were examined in ovariectomized, estrogen-primed rats. Gastrin or cholecystokinin-octapeptide injection in the preoptic region induced a moderate increase of circadian r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90330-1
更新日期：1987-05-05 00:00:00
abstract：:Motor cortex stimulation (MCS) is a promising clinical procedure to help alleviate chronic pain. Animal models demonstrated that MCS is effective in lessening nocifensive behaviors. The present study explored the effects of MCS on cortical somatosensory evoked potentials (SEPs) recorded at the primary somatosensory co...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.04.027
更新日期：2012-06-29 00:00:00
abstract：:The content and turnover of dopamine, norepinephrine and 5-hydroxytryptamine (serotonin), and the content of their respective major metabolites were evaluated in 19 discrete brain areas of rats exposed to conditioned emotional response (CER), and in control groups which received either equivalent yoked shock (shock on...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90647-3
更新日期：1982-05-20 00:00:00
abstract：:Excitotoxic effects leading to neuronal cell degeneration are often accompanied by a prolonged increase in the intracellular level of Ca(2+) ions and L-glutamate-induced toxicity is assumed to be mediated via a Ca(2+)-dependent mechanism. Due to their buffering properties, EF-hand Ca(2+)-binding proteins (CaBPs) can a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02753-1
更新日期：2002-08-02 00:00:00
abstract：:Effects of protein kinase C (PKC) activation on the function of the GABA/benzodiazepine receptor-chloride complex were analyzed by quantitative autoradiography using [3H]muscimol, [3H]flunitrazepam and [35S]TBPS in rat brain slices. The density of [3H]muscimol binding was highest in cerebellar granular layers and high...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02127-7
更新日期：1999-12-11 00:00:00
abstract：:Molecular events associated with mnemonic processes and neuronal plasticity are postulated to result in functional changes in synaptic structure. One possible site is the post-synaptic density, where activity-dependent changes modulate signal transduction cascades. In this report, we detail spatial-temporal changes fo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.02.023
更新日期：2005-04-18 00:00:00
abstract：:Opioid antagonists block the positive hedonic response to food taste and are potent inhibitors of palatability-driven feeding. However, the specific brain regions within which opioid peptide secretion contributes to the maintenance of palatability-driven feeding have not been clearly established. In the present study,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00719-7
更新日期：1998-09-14 00:00:00
abstract：:The role of astrocytes in glutamate toxicity has been controversial. Here, we show that astrocytes in neuron-astrocyte co-cultures increased neuronal sensitivity to chronic glutamate exposure but not to acute exposure. Enhanced neuronal toxicity by chronic exposure was dependent on astrocyte cell numbers. A reduced ge...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.10.015
更新日期：2014-11-24 00:00:00
abstract：:The motivational effects of exclusively peripheral or central opiate receptor blockade were studied using place conditioning. Place aversions were observed with intraventricular (i.c.v.) methylnaloxone (MN) in both naive (200-1000 ng) and morphine-dependent rats (50-500 ng). Subcutaneous MN (0.03-10 mg/kg) was ineffec...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90452-0
更新日期：1988-12-06 00:00:00
abstract：:Williams Syndrome (WS) is a neurodevelopment disorder associated with a hemizygous deletion on chromosome 7. WS is characterized with mental retardation, severe visual-spatial deficits, relative language preservation, and excellent facial recognition. Distinctive auditory features include musical ability, heightened s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.11.038
更新日期：2005-03-10 00:00:00
abstract：:The dynamics of regional cerebral blood flow and brain extracellular glucose were studied in the freely moving rat. These two variables were measured in the striatum during and following both mild tail pinch and restraint stress. Blood flow was monitored using a refinement of the hydrogen clearance technique that allo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90373-u
更新日期：1993-02-26 00:00:00
abstract：:Platelet-derived growth factor-B (PDGF-B) is a growth factor that regulates cell migration, proliferation, and differentiation, and is involved in several physical and pathological processes. The overexpression of PDGF-B in glioma surgical samples revealed its effect on tumorigenesis. In this study, we determined that...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.01.045
更新日期：2014-03-27 00:00:00
abstract：:Using a specific antibody against each of the 4 catecholamine-synthesizing enzymes, dopamine or serotonin, we compared the localization of these substances in rat and mouse spinal cord with two kinds of fixative, such as paraformaldehyde and glutaraldehyde, and two types of sectioning technique, i.e. cryostat and micr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90202-8
更新日期：1988-12-13 00:00:00
abstract：:Administration of methamphetamine (15 mg/kg) to adrenalectomized rats significantly decreased hippocampal type I and II corticosteroid receptors as well as type II receptors in the striatum. Type II receptors in the frontal cortex and hypothalamus were unaffected by methamphetamine administration. Pretreatment with MK...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91362-k
更新日期：1990-11-19 00:00:00
abstract：:A diffusion model is described here, which allows for the estimations of drug concentration changes in porous media, such as in slice tissues of the central nervous system (CNS) bathed in unstirred solutions following abrupt changes of drug concentration. This model may be used for the interpretation of data obtained ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91523-x
更新日期：1987-12-22 00:00:00
abstract：:gamma-Aminobutyric acid (GABA), pentobarbital and ethanol were applied by bath superfusion to rat locus coeruleus (LC) neurons in a brain slice preparation. The GABA-induced current and conductance increase was measured with single-electrode voltage clamp. Pentobarbital potentiated the GABA-induced current and conduct...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91044-h
更新日期：1990-05-28 00:00:00
abstract：:Acupuncture is widely used to relieve pain; however, the mechanism underlying electroacupuncture analgesia (EAA) during inflammatory pain is unclear. We investigated whether endogenous peripheral opioid receptors participated in EAA during hyperalgesia elicited by carrageenan-induced inflammation. Moreover, we investi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.08.014
更新日期：2010-10-08 00:00:00
