Abstract：
:The modulation of serotonin (5-HT) release by opioid receptors in the hippocampus of the awake, unrestrained rat was evaluated by use of in vivo microdialysis. The hippocampus was perfused with Ringer's solution (2 microliters/min), and extracellular levels of 5-HT and its major metabolite, 5-hydroxyindoleacetic acid (5-HIAA) were estimated by assaying their concentration in the dialysate by HPLC-ECD. Addition of potassium (K+, 60 and 120 mM) to the perfusate evoked a concentration-dependent release of 5-HT, but did not alter extracellular 5-HIAA levels. Co-perfusion of morphine (0.1 to 10 microM) with K+ (120 mM) produced a concentration-dependent reduction of 5-HT release. Naltrexone (0.03 to 3 mg/kg, i.p.), a relatively selective mu-opioid receptor antagonist, blocked in a dose-dependent manner the morphine (10 microM)-induced inhibition of 5-HT release. Naltrexone alone did not alter significantly either extracellular 5-HT levels or the release of 5-HT evoked by K+. Neither co-perfusion with [D-Pen2, D-Pen5]-enkephalin (DPDPE, 1 to 10 microM), an agonist selective for delta-opioid receptors, nor with U-69593 (10 microM), an agonist selective for kappa-opioid receptors, modified the K+ (120 mM)-evoked release of 5-HT. These findings indicate that mu-opioid receptors modulate the physiological release of 5-HT from serotonergic neurons in the rat hippocampus.
journal_name
Brain Resjournal_title
Brain researchauthors
Yoshioka M,Matsumoto M,Togashi H,Smith CB,Saito Hdoi
10.1016/0006-8993(93)90456-wsubject
Has Abstractpub_date
1993-06-04 00:00:00pages
74-9issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(93)90456-Wjournal_volume
613pub_type
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