Abstract：
:The expression of the calcium-binding protein calretinin (CR) in the chick cochlear nucleus, nucleus magnocellularis (NM), was examined after unilateral cochlea removal in hatchlings and 3-week-old birds. Following survival times of 3, 6 or 12 h or 1, 3 or 7 days, CR mRNA was localized by in situ hybridization using a radiolabeled chick CR probe. Levels of CR protein were assessed by CR-immunoreactivity (CR-I) using a calcium-independent CR antiserum and immunohistochemistry. At survival times of 1 day or less, cochlea removal did not change relative levels of CR mRNA or CR-I in NM between the deafferented and the unoperated sides of the brain. Decreases in CR expression on the cochlea removal side were observed, however, at times that coincide with deafferentation-induced cell loss (3 and 7 days). Additionally, bilateral cochlea removal had no apparent effect on CR-I in NM neurons when compared to those in normal animals. Thus, CR mRNA and protein appear to be constitutively expressed in NM neurons and are not affected by sensory deprivation.
journal_name
Brain Resjournal_title
Brain researchauthors
Stack KE,Code RAdoi
10.1016/s0006-8993(00)02476-8subject
Has Abstractpub_date
2000-08-04 00:00:00pages
135-9issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(00)02476-8journal_volume
873pub_type
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