D-fenfluramine activates rat oxytocinergic and vasopressinergic neurons through different mechanisms.

Abstract:

:Activation of serotonin neurotransmission produces increase of plasma oxytocin, prolactin, vasopressin and ACTH levels. Using dual-immunocytochemistry, the number of oxytocinergic neurons in the hypothalamic magnocellular nuclei co-storing Fos after administration of D-fenfluramine was found to be 15-fold higher compared to vehicle, comprising about 30% of the total number of these neurons. Vasopressinergic neurons were virtually not affected. These results show that serotonergic neurotransmission induces Fos transcription in oxytocinergic neurons that may lead to a release of oxytocin to the general circulation, whereas vasopressinergic neurons are activated through another mechanism.

journal_name

Brain Res

journal_title

Brain research

authors

Mikkelsen JD,Jensen JB,Engelbrecht T,Mørk A

doi

10.1016/s0006-8993(99)01953-8

subject

Has Abstract

pub_date

1999-12-18 00:00:00

pages

247-51

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(99)01953-8

journal_volume

851

pub_type

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