Abstract:
:Activation of serotonin neurotransmission produces increase of plasma oxytocin, prolactin, vasopressin and ACTH levels. Using dual-immunocytochemistry, the number of oxytocinergic neurons in the hypothalamic magnocellular nuclei co-storing Fos after administration of D-fenfluramine was found to be 15-fold higher compared to vehicle, comprising about 30% of the total number of these neurons. Vasopressinergic neurons were virtually not affected. These results show that serotonergic neurotransmission induces Fos transcription in oxytocinergic neurons that may lead to a release of oxytocin to the general circulation, whereas vasopressinergic neurons are activated through another mechanism.
journal_name
Brain Resjournal_title
Brain researchauthors
Mikkelsen JD,Jensen JB,Engelbrecht T,Mørk Adoi
10.1016/s0006-8993(99)01953-8subject
Has Abstractpub_date
1999-12-18 00:00:00pages
247-51issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(99)01953-8journal_volume
851pub_type
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