Abstract:
:We studied whether interleukin-1 (IL-1) affects the release of arginine vasopressin (AVP) from the superfused hypothalamo-neurohypophyseal complex (HNC) of rats. Involvement of the cholinergic system in the mediation of IL-1 on AVP release from HNC was also examined. Both human recombinant IL-1 alpha and -1 beta elicited a rapid increase of AVP from HNC in a dose-dependent manner at concentrations ranging from 0.1 to 10 nM. However, neither IL-1 alpha nor -1 beta at concentrations of 100 nM increased AVP, and even suppressed the stimulatory effect of 10 nM IL-1 alpha and -1 beta added later. Acetylcholine at concentrations of 1 to 100 nM caused a dose-dependent, rapid increase in AVP, whereas AVP release induced by 10 nM acetylcholine was completely suppressed by the combined presence of 10 microM hexamethonium, a nicotinic receptor antagonist, and 50 microM atropine, a muscarinic receptor antagonist. On the other hand, AVP release induced by 10 nM IL-1 alpha and -1 beta was not affected by the combination of the two antagonists. These results suggest that both IL-1 alpha and -1 beta may stimulate AVP release by acting directly on the hypothalamo-neurohypophyseal system, and that the stimulatory effect of IL-1 on AVP release may be independent of the cholinergic system.
journal_name
Brain Resjournal_title
Brain researchauthors
Nakatsuru K,Ohgo S,Oki Y,Matsukura Sdoi
10.1016/0006-8993(91)90169-vsubject
Has Abstractpub_date
1991-07-19 00:00:00pages
38-45issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(91)90169-Vjournal_volume
554pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The effect of intracerebroventricular administration of low-antinociceptive doses of selective mu- (DAMGO) or delta- (DPDPE) opioid agonists on the dose-dependent antinociceptive effects produced by intrathecal administration of sequentially increasing doses of selective mu-, delta-, or kappa-(U50,488H) opioid agonist...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91449-o
更新日期:1992-11-06 00:00:00
abstract::Here we describe a sustained outward potassium current (IK) in retinal horizontal cells (HCs). IK is unusually small over the range of membrane potentials normally experienced by these cells, which are chronically depolarized. We hypothesize that this unique IK will reduce the amount of neurotransmitter required to sh...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90204-o
更新日期:1990-09-24 00:00:00
abstract::Moyamoya disease (MMD) is a chronic occlusive cerebrovascular disease with unknown etiology that is characterized by the development of abnormal vascular networks at the base of the brain. Recent genome-wide studies identified RNF213 as an important MMD susceptibility gene. However, the exact mechanism by which the RN...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.11.014
更新日期:2015-01-12 00:00:00
abstract::Earlier studies showed that pretreatment (3 and 6 h) of rats with the glucocorticoid hormone, dexamethasone, potentiated the drinking response to either central or peripheral administration of angiotensin II (AII). In the present study the specificity and mechanisms of this potentiation were examined. Intraperitoneal ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90093-b
更新日期:1991-06-28 00:00:00
abstract::Oligodendrocytes (OLs), the predominant cell type found in cerebral white matter, are essential for structural integrity and proper neural signaling. Very little is known concerning stroke-induced OL dysfunction. Our laboratory has shown that infusion of human umbilical cord blood (HUCB) cells protects striatal white ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.09.078
更新日期:2010-12-17 00:00:00
abstract::This work describes the change in an active electrogenesis of the command neurons responsible for defensive closure of a snail's pneumostome during elaborating, extinction and restoration of a classical conditioned defensive reflex to a tactile stimulus. Tactile stimulations applied to different parts of a snail's bod...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91453-l
更新日期:1992-11-06 00:00:00
abstract::Alterations occurring in the antioxidant enzymes, copper, zinc-dependent superoxide dismutase (Cu,Zn-SOD) and glutathione peroxidase (GPX) following nigral dopaminergic denervation are unclear. We now report on the distribution and levels of m-RNA for Cu,Zn-SOD and GPX in basal ganglia of normal and 1-methyl-4-phenyl-...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02240-6
更新日期:2003-04-11 00:00:00
abstract::Poor sleep and insomnia have been recognized to be strongly correlated with the development of depression. The exploration of the basic mechanism of sleep disturbance could provide the basis for improved understanding and treatment of insomnia and prevention of depression. In this study, 31 subjects with insomnia symp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.07.024
更新日期:2016-10-01 00:00:00
abstract::Several studies have recently shown that basal and stress-induced secretion of corticosterone may enhance vulnerability to drugs of abuse. In this report, we studied the effects of metyrapone, an inhibitor of the synthesis of corticosterone, on cocaine-induced locomotion and on the relapse of cocaine self-administrati...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(09)90034-8
更新日期:1994-09-26 00:00:00
abstract::Three types of hyperpolarization in response to applied acetylcholine (ACh) were observed in 4 identified neurones (RP1, RP2, RP3 and RP4) in the right parietal ganglion of the African giant snail, Achatina fulica Férussac. In order to clarify the ionic mechanisms of these responses, the neurones were voltage-clamped ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90416-6
更新日期:1986-05-28 00:00:00
abstract::The influence of dopamine D1 receptor agonist, SKF 38393 has been studied in vitro in the model of low calcium spontaneous epileptiform discharges. Application of SKF 38393 (3 microM) to the perfusing medium evoked a decrease in neuronal firing rate of hippocampal CA1 neurons. The effect of SKF 38393 was blocked by pr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90208-s
更新日期:1990-09-24 00:00:00
abstract:PURPOSE:Diffusion kurtosis imaging (DKI) is a MRI technique which can measure alterations in the diffusion of water molecules to reflect tissue changes in both white and grey matter. This study evaluated the potential of DKI for the early diagnosis of radiation-induced temporal lobe changes in the grey and white matter...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.07.041
更新日期:2016-10-01 00:00:00
abstract::Scratching elicited by the intrathecal (i.t.) administration of substance P (SP) into the lumbosacral spinal cord of rats was not reduced by spinalization or i.t. pretreatment with the analgesic morphine. Spinalization also did not affect scratching elicited by i.t. kainic acid and potentiated scratching elicited by i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90081-9
更新日期:1988-07-12 00:00:00
abstract::The present study aimed to determine whether the observation of different grasps of the same object elicits automatic imitation of the kinematics of those grasps and this process influences the estimation of intrinsic target properties. In experiments 1 and 2, participants reached and grasped differently sized spheres...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.04.046
更新日期:2008-07-07 00:00:00
abstract::The Wistar Audiogenic Rat (WAR) is a genetic model of reflex epilepsy with seizures induced by high-intensity sound stimulation (120 dB SPL). In spite of the known neural substrates involved in WAR seizure phenotype, neuroendocrine hypothalamic neurons were never investigated. In this work, AVP immunohistochemistry in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.12.030
更新日期:2005-03-15 00:00:00
abstract::Different mechanisms have been suggested to contribute to isoflurane-mediated neuroprotection. Previous studies have suggested that the protein Slit can abrogate neuronal death in mixed neuronal-glial cultures exposed to oxygen-glucose deprivation (OGD) and reperfusion (OGD/R). We hypothesized that isoflurane increase...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.08.036
更新日期:2013-11-06 00:00:00
abstract::In acute cats deeply anesthetized with Nembutal, monosynaptic excitatory postsynaptic potentials (EPSPs) triggered by stimulation of the ventrolateral (VL) thalamic nucleus and the pes pedunculus were recorded in large pyramidal tract cells (PT cells). Deep anesthesia, low intensities of stimulation and an averaging t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90598-5
更新日期:1979-01-05 00:00:00
abstract::Glucose modulates substantia nigra (SN) dopamine (DA) neuronal activity and GABA axon terminal transmitter release by actions on an ATP-sensitive potassium channel (K(ATP)). Here, the effect of altering SN glucose levels on striatal DA release was assessed by placing microdialysis probes into both the SN and striatum ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02573-7
更新日期:2000-08-25 00:00:00
abstract::Structural changes induced by high frequency (HF) stimulation on granule cells of the hippocampal dentate gyrus of rats with inborn high (HP) and low (LP) learning capacity was examined in this study. Two types of axodendritic synapses were processed morphometrically; the axonal bouton on dendritic shafts and those ma...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90371-h
更新日期:1990-12-24 00:00:00
abstract::Although cocaine shares the ability of fenfluramine to inhibit the synaptic reuptake of serotonin, previous observations from our group suggest that the genomic effects of fenfluramine in the rat striatum are primarily mediated by dopaminergic rather than serotonergic mechanisms. To compare and further understand the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91391-9
更新日期:1994-05-30 00:00:00
abstract::We have elucidated the spatial and temporal localization of Cdk5 and p35nck5a in the developing rat postnatal cerebellum. Both proteins were highly expressed in cell bodies of post mitotic and immature neurons. The localization of Cdk5 in cellular compartment was changed from cell body to the axon in development. On t...
journal_title:Brain research
pub_type: 杂志文章
doi:
更新日期:1996-09-23 00:00:00
abstract::Neurturin (NTN) is a recently discovered neurotrophic factor related to glial cell line-derived neurotrophic factor (GDNF) and has a wide spectrum of biological roles in different types of neurons in the central and peripheral nervous systems. However, information on its expression in peripheral tissues has been limit...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01590-5
更新日期:1999-07-24 00:00:00
abstract::Neuropeptide Y (NPY, 1 and 10 pmol), NPY Y1 receptor agonist [Leu31, Pro34]NPY (10 pmol) and Y2 agonist NPY13-36 (100 pmol) were administered unilaterally into the region of the nucleus locus coeruleus (LC) in rats. NPY (10 pmol) and NPY13-36 increased the percentage of open arm entries, the percentage of time spent o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00076-6
更新日期:1998-03-30 00:00:00
abstract::Quantitative autoradiographic analysis was used to identify regions in the brain of the male primate where androgen binding sites may be involved in the actions of testosterone. Three days after castration, adult male rhesus monkeys received a subcutaneous injection of either dihydrotestosterone propionate (DHTP, 20 m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90456-3
更新日期:1989-11-13 00:00:00
abstract::Myelin of several Caudata (Urodela) species appears to be unique in the fact that it lacks hydroxycerebrosides and hydroxysulfatides although it contains their non-hydroxy counterparts. Comparison of the nerve conduction velocities in the Urodeles Necturus (salamander) and Notophthalmus (newt) with that in a reptile, ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90831-5
更新日期:1985-10-14 00:00:00
abstract::The growth inhibitory factor (GIF) is a new metallothionein (MT)-like protein that is downregulated in Alzheimer's disease (AD) brain. The biological function of GIF has not been fully clarified yet. We have raised an antibody to the synthetic polypeptide that is specific for rat GIF. The purified antibody reacted to ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00522-r
更新日期:1995-08-07 00:00:00
abstract::Dorsal root ganglia (DRG) are key elements in sensory signaling under physiological and pathological conditions. Little is known about electrical coupling among cells in these ganglia. In this study, we injected the fluorescent dye Lucifer yellow (LY) into single cells to examine dye coupling in DRG. We found no dye c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.12.021
更新日期:2005-03-02 00:00:00
abstract::Using the acetylthiocholine staining method, it was possible to visualize acetylcholinesterase (AChE)-stained neuronal cell bodies and nerve endings as well as AChE-positive vesicles in the rat duodenum. AChE-reactive perikarya were seen with certainty only in the myenteric plexus. They were 40 micron in diameter and ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90100-3
更新日期:1985-07-29 00:00:00
abstract::Defeat stress in mice, a model of social stress, increases benzodiazepine receptor binding as measured by specific [3H]Ro15-1788 binding in vivo, but not by [3H]flunitrazepam binding in vitro. This increase occurs rapidly, by 20 min following exposure to stress, and resolves by 60 min. Increased benzodiazepine recepto...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90023-0
更新日期:1987-06-30 00:00:00
abstract::The involvement of terminal sprouts in neurotransmitter release by in vivo botulinum type-A toxin poisoned motor endings was investigated 15 to 40 days after a single injection of the toxin onto the levator auris longus muscle of the mouse. Enhanced quantal acetylcholine release was induced by alpha-latrotoxin or La3+...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00475-2
更新日期:1998-06-29 00:00:00