Apamin, a blocker of the calcium-activated potassium channel, induces neurodegeneration of Purkinje cells exclusively.

abstract：:Adult Long-Evans female rats sustained electrolytic fimbria-fornix lesions and, two weeks later, received intrahippocampal suspension grafts of fetal septal tissue. Sham-operated and lesion-only rats served as controls. Between 6.5 and 8 months after grafting, both the [3H]choline accumulation and the electrically evo...

journal_title：Brain research

authors： Cassel JC,Jeltsch H,Neufang B,Lauth D,Szabo B,Jackisch R

更新日期：1995-12-18 00:00:00

abstract：:This study investigates the reanalysis processes as a consequence of conflict between incompatible sentential representations in sentence comprehension. Using the event-related potential (ERP) technique, we examined the situation in which the sentential representation built upon world knowledge (i.e., the plausibility...

journal_title：Brain research

authors： Ye Z,Zhou X

更新日期：2008-04-08 00:00:00

abstract：:A selective 5-HT reuptake inhibitor, fluvoxamine (10 and 30 mg/kg, i.p.) suppressed long-term potentiation (LTP) in the hippocampal CA1 field of anesthetized rats. Fluvoxamine (30 mg/kg, i.p.)-induced suppression of LTP was completely reversed by the 5-HT(1A) receptor antagonist NAN-190 (0.5 mg/kg, i.p), but not by th...

journal_title：Brain research

authors： Kojima T,Matsumoto M,Togashi H,Tachibana K,Kemmotsu O,Yoshioka M

更新日期：2003-01-03 00:00:00

abstract：:Conditions for the stimulation of taurine release by illumination or increased K+ concentrations were established. The effect of Mg2+, ruthenium red and verapamil on taurine release induced by both procedures was compared. All these agents antagonize Ca2+-dependent release of neurotransmitters. Illumination-induced re...

journal_title：Brain research

authors： López-Colomé A,Erlij D,Pasantes-Morales H

更新日期：1976-09-03 00:00:00

abstract：:Even though animal and human studies show alterations in dopamine transporter (DAT) sites after alcohol withdrawal, the role of DAT in influencing either alcoholic or depressive behavior has not been examined extensively. Given that the Wistar-Kyoto (WKY) rat is a putative animal model of depressive behavior, the pres...

journal_title：Brain research

authors： Jiao X,Paré WP,Tejani-Butt SM

更新日期：2006-02-16 00:00:00

abstract：:Vagus nerve stimulation (VNS) has been used for years to treat patients with drug-resistant epilepsy. In the present study, the effect of different stimulation protocols of VNS on the hippocampal formation (HPC) type II theta field potentials were evaluated in anesthetized rats. The following theta parameters were ana...

journal_title：Brain research

authors： Broncel A,Bocian R,Kłos-Wojtczak P,Konopacki J

更新日期：2017-11-15 00:00:00

abstract：:We have examined the soma diameters and distribution of catecholaminergic (CA) cells in human retinae, by using an antibody to tyrosine hydroxylase (TH), the rate limiting enzyme in the production of catecholamines. TH-immunoreactivity was detected in two classes of cells (CA1 and CA2 cells). CA1 cells had relatively ...

journal_title：Brain research

authors： Mitrofanis J,Provis JM

更新日期：1990-09-10 00:00:00

abstract：:In the first postnatal month, the thickness of the cerebral cortex has different patterns of development in the male and female Long-Evans rat. All areas of the male cortex appear to develop at similar rates, very rapidly for the first 10 days, then more gradually reaching a peak somewhere between 30 and 40 days of ag...

journal_title：Brain research

authors： Diamond MC

更新日期：1987-05-01 00:00:00

abstract：:The effect of excitatory amino acid antagonists on antagonist on neuropeptide Y (NPY) and cholinergic neurons in the striatum of the rat was studied by means of NPY immunocytochemistry, DFP histochemistry for acetylcholinesterase (AChE), and biochemical determinations of choline acetyltransferase (ChAT). Intrastriatal...

journal_title：Brain research

authors： Boegman RJ,Parent A

更新日期：1988-06-14 00:00:00

abstract：:Following injections of WGA-HRP into lower cervical segments, the distribution of anterograde labeled terminals of spinocerebellar fibers was examined in the vermal cortex of the cat. The labeled terminals were seen in sublobules Ib to VIc, VIIb, VIIIa and VIIIb, and lobule IX. They were present mainly in the medial p...

journal_title：Brain research

authors： Matsushita M,Ikeda M,Tanami T

更新日期：1985-12-23 00:00:00

abstract：:The insula has emerged as a critical target for electrical stimulation since it influences pathological pain states. We investigated the effects of repetitive electrical stimulation of the insular cortex (ESI) on mechanical nociception, and general locomotor activity in rats subjected to chronic constriction injury (C...

journal_title：Brain research

authors： Alonso-Matielo H,Gonçalves ES,Campos M,Oliveira VRS,Toniolo EF,Alves AS,Lebrun I,de Andrade DC,Teixeira MJ,Britto LRG,Hamani C,Dale CS

更新日期：2021-01-02 00:00:00

abstract：:Glucocorticoid receptor (Gr) concentrations in the rat brain are low at the time of birth and increase towards adult levels during the first two weeks of life. Brief, daily handling of pups for the first 21 days postnatally has been found to permanently increase Gr concentrations within the hippocampus. Thus, the deve...

journal_title：Brain research

authors： Meaney MJ,Aitken DH

更新日期：1985-10-01 00:00:00

abstract：:Ferulic acid (FA) has an important effect on scavenging free radicals, which is related to the alleviation of various neurodegenerative diseases. However, there are few studies about its effects on vascular dementia. In this study, we demonstrated the effect of FA on oxidative damage of brain microvascular endothelial...

journal_title：Brain research

authors： Chen JL,Duan WJ,Luo S,Li S,Ma XH,Hou BN,Cheng SY,Fang SH,Wang Q,Huang SQ,Chen YB

更新日期：2017-07-01 00:00:00

abstract：:A progressive model of Parkinson's disease has been recently developed in the rat where a unilateral excitotoxic injection into the globus pallidus leads to a gradual loss of dopaminergic neurons in the ipsilateral substantia nigra over a period of at least 6 weeks. In this model microglial activation is observed in t...

journal_title：Brain research

authors： Wright AK,Miller C,Williams M,Arbuthnott G

更新日期：2008-06-24 00:00:00

abstract：:Electrical stimulation of the brain, particularly in the periventricular grey areas, caused long-lasting increases in behavioural escape thresholds to heating and mechanical stimuli applied to the facial region of the rat. The brain stimulation selectively suppressed responses to noxious stimuli. Responses to non-noxi...

journal_title：Brain research

authors： Cahusac PM,Morris R,Hill RG

更新日期：1995-11-27 00:00:00

abstract：:We have recently reported that hypothyroidism increases immunoreactive (IR)-vasoactive intestinal polypeptide (VIP) and VIP mRNA content in both parvocellular and magnocellular neurons of the rat, hypothalamic paraventricular nucleus (PVN). As VIP can stimulate vasopressin (AVP) secretion, we conducted an anatomical i...

journal_title：Brain research

authors： Toni R,Mosca S,Ruggeri F,Valmori A,Orlandi G,Toni G,Lechan RM,Vezzadini P

更新日期：1995-06-05 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by upper and lower motor neuron death with ascending paralysis leading to death. In a transgenic mouse model of ALS (SOD1-G93A) weakness appears at 3 months of age, and because of progressive paralysis leads to death by 5 months. Cyclospo...

journal_title：Brain research

authors： Keep M,Elmér E,Fong KS,Csiszar K

更新日期：2001-03-16 00:00:00

abstract：:The hippocampus is involved in key neuronal circuits that underlie cognition, memory, and anxiety, and it is increasingly recognized as a vulnerable structure that contributes to the pathogenesis of HIV-associated neurocognitive disorder (HAND). However, the mechanisms responsible for hippocampal dysfunction in neuroH...

journal_title：Brain research

authors： Sokolova IV,Szucs A,Sanna PP

更新日期：2019-12-01 00:00:00

abstract：:Event-related potentials (ERP) were measured when pleasant, neutral or unpleasant pictures were presented in the context of similarly valenced stimuli, and compared to ERPs elicited when the same pictures were viewed in an intermixed context. An early ERP component (150-300 ms) measured over occipital and fronto-centr...

journal_title：Brain research

authors： Pastor MC,Bradley MM,Löw A,Versace F,Moltó J,Lang PJ

更新日期：2008-01-16 00:00:00

abstract：:Metabolic stress imposed by epileptic seizures can result in mitochondrial dysfunction, believed to act as positive feedback on epileptogenesis and seizure susceptibility. As the mechanism behind this positive feedback is unclear, the aim of the present study was to investigate the causal link between acute mitochondr...

journal_title：Brain research

authors： Andreasen M,Nedergaard S

更新日期：2021-01-15 00:00:00

abstract：:This study was designed to evaluate the functional significance of angiotensin II (Ang II) receptors identified by previous receptor autoradiography studies to be located presynaptically on terminals of dopaminergic neurones projecting to the striatum. Microdialysis was performed in the striatum of conscious freely mo...

journal_title：Brain research

authors： Mendelsohn FA,Jenkins TA,Berkovic SF

更新日期：1993-06-11 00:00:00

abstract：:An in vitro method has been developed to determine quantitatively the permeability of the perineurium to radiotracers at room temperature. The permeability to [14C]sucrose of the isolated perineurium of the sciatic nerve of the frog, Rana pipiens, was measured at rest length, when the perineurium was stretched and aft...

journal_title：Brain research

authors： Weerasuriya A,Rapoport SI,Taylor RE

更新日期：1979-09-21 00:00:00

abstract：:The recruitment of performance control was recently explained in terms of the detection of response conflict. One recent hypothesis claims that the degree of response conflict is reflected in an electroencephalographical component, the Error Negativity (Ne). Indeed, in the framework of simulations, variations of the N...

journal_title：Brain research

authors： Carbonnell L,Falkenstein M

更新日期：2006-06-20 00:00:00

abstract：:We assessed the effects of simulated weightlessness, hindlimb unloading (HU) by 7 days of tail suspension, on noxious mechanically and heat evoked spinal withdrawal reflexes and spinal Fos expression during muscle nociception elicited by intramuscular (i.m.) injection of hypertonic (HT; 5.8%) saline into gastrocnemius...

journal_title：Brain research

authors： Lei J,Pertovaara A,You HJ

更新日期：2015-01-12 00:00:00

abstract：:Ramified microglial cells were investigated in primary cultures of dissociated cerebral cortical tissue from rats. The identification of these cells was confirmed through immunohistochemical staining with 7 monoclonal antibodies selective for microglia. While there was significant variation in staining intensity with ...

journal_title：Brain research

authors： Booth PL,Thomas WE

更新日期：1991-05-10 00:00:00

abstract：:Stanniocalcin (STC-1), a 50 kDa glycoprotein hormone that regulates calcium/phosphate homeostasis in bony fish and mammals, has been shown to be expressed in central neurons and choroid plexus, and to exert a protective effect against hypercalcemic and hypoxic damage to neurons. Circumventricular organs are known to f...

journal_title：Brain research

authors： Ratkovic S,Wagner GF,Ciriello J

更新日期：2008-07-07 00:00:00

abstract：:The malformative cortical lesions in the cerebral cortex that are characteristic of focal cortical dysplasia type IIb (FCDIIb) and tuberous sclerosis complex (TSC) are well-recognized causes of chronic intractable epilepsy in children. Increasing evidence suggests that extracellular matrix molecules play important rol...

journal_title：Brain research

authors： Li S,Yu S,Zhang C,Shu H,Liu S,An N,Yang M,Yin Q,Yang H

更新日期：2012-05-09 00:00:00

abstract：:The present study examined dopamine-immunoreactive neuronal structures using immunohistochemistry in conjunction with an anti-dopamine antiserum, following injection of l-3,4-dihydroxyphenylalanine (L-DOPA) with or without an inhibitor of monoamine oxidase (Pargyline) in the cat brain. L-DOPA injection made it possibl...

journal_title：Brain research

authors： Kitahama K,Geffard M,Araneda S,Arai R,Ogawa K,Nagatsu I,Pequignot JM

更新日期：2007-09-05 00:00:00

abstract：:A study of brains of 16 dogs from one to 19 years of age showed a structure- and cell-type- specific pattern of tau protein phosphorylation at mAb Tau-1 site and the absence of phosphorylation at the mAb AT8 site. Strong immunolabeling with mAb Tau-1 of the mossy fibers and perikarya of neurons in sectors CA3 and CA4 ...

journal_title：Brain research

authors： Wegiel J,Wisniewski HM,Sołtysiak Z

更新日期：1998-08-17 00:00:00

abstract：:The regulation of corticosteroid receptor expression in the rat brain by adrenal steroids remains controversial. The results of in vivo studies [Brinton and McEwen, 1988; Luttge et al., 1989] suggest that activation of type I receptors can modulate both mineralocorticoid (MR; type I) and glucocorticoid (GR; type II) r...

journal_title：Brain research

authors： O'Donnell D,Meaney MJ

更新日期：1994-02-04 00:00:00