Abstract：
:A progressive model of Parkinson's disease has been recently developed in the rat where a unilateral excitotoxic injection into the globus pallidus leads to a gradual loss of dopaminergic neurons in the ipsilateral substantia nigra over a period of at least 6 weeks. In this model microglial activation is observed in the ipsilateral substantia nigra 3 weeks after the lesion and could contribute to neuronal death at this time. The immunosuppressant drug tacrolimus (FK506) reduces dopamine cell death at 3 weeks following a globus pallidus lesion, but not thereafter. Tacrolimus-mediated neuroprotection could result from suppression of microglial activation but the microglial activation at three weeks post-lesion was not much reduced. Microglial activation was observed even in the apparent absence of neuronal death, prompting the suggestion that tacrolimus may prevent, or at least delay, the release of toxic cytokines from activated microglia. By 6 weeks after the GP lesion, even this mechanism fails to protect the dopamine cells from damage.
journal_name
Brain Resjournal_title
Brain researchauthors
Wright AK,Miller C,Williams M,Arbuthnott Gdoi
10.1016/j.brainres.2008.04.020subject
Has Abstractpub_date
2008-06-24 00:00:00pages
78-86eissn
0006-8993issn
1872-6240pii
S0006-8993(08)00938-4journal_volume
1216pub_type
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