Abstract：
:Reactive oxygen species (ROS) and intrinsic antioxidant defense systems play an important role in both physiological cell signaling processes and many pathological states, including neurodegenerative disorders and oxygen-toxicity. Here we report that short exposures to non-physiologic oxygen levels change the balance of the ROS-dependent thioredoxin/peroxiredoxin system in the developing rat brain. The aim of this study was to evaluate the expression of peroxiredoxins, thioredoxin 1, sulfiredoxin 1, and DJ-1 on gene and protein level under hyperoxic conditions. Six-days old Wistar rats were exposed to 80% oxygen for 6-48 h while sex-matched littermates were kept in room-air and served as controls. Oxygen-toxicity significantly induced upregulation of peroxiredoxins 1 and 2, peroxiredoxin sulfonic form, thioredoxin 1, and sulfiredoxin 1 in the brains of infant rats. Additionally, hyperoxia reduced the level of DJ-1, a hydroperoxide-responsive protein in the developing rat brain. The pathology of hyperoxia-mediated injury to the developing brain is still elusive and oxygen administration to neonates is often inevitable. These findings may provide evidence for the development of targeted therapeutic strategies to enhance the antioxidative defense of the immature brain.
journal_name
Brain Resjournal_title
Brain researchauthors
Bendix I,Weichelt U,Strasser K,Serdar M,Endesfelder S,von Haefen C,Heumann R,Ehrkamp A,Felderhoff-Mueser U,Sifringer Mdoi
10.1016/j.brainres.2012.09.024subject
Has Abstractpub_date
2012-11-12 00:00:00pages
68-75eissn
0006-8993issn
1872-6240pii
S0006-8993(12)01506-5journal_volume
1484pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Glucocorticoids exacerbate aging-induced cell death, but relatively little is known about other CNS effects in senescence. We examined noradrenergic/adenylyl cyclase signaling in the cerebellum, which is a brain region that is susceptible to deterioration of synaptic function in aging. Aged control rats had increased ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00518-6
更新日期：1998-08-03 00:00:00
abstract：:In a study of the capacity of neural grafts to promote functional recovery in rats with fimbria-fornix lesions, 5 groups of rats were studied behaviourally and with acetylcholinesterase (AChE) histochemistry: (1) sham-operated controls; (2) bilateral fimbria-fornix lesions; (3) bilateral lesions plus bilateral solid e...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90751-x
更新日期：1982-11-18 00:00:00
abstract：:Putative serotonergic dorsal raphe (DRN) neurons display a dramatic state-related change in behaviour, discharging regularly at a high rate during waking and at progressively slower rates during slow-wave sleep (SWS) and ceasing firing during paradoxical sleep (PS). Using the antidromic latency technique and extracell...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02210-7
更新日期：2001-04-20 00:00:00
abstract：:Chronic intermittent hypoxia (CIH) may cause sustained systemic hypertension by increasing sympathetic neural discharge (SND). We hypothesized that CIH alters brainstem circuits modulating SND. After 30 days of CIH exposure in rats, increased c-fos labeling was seen in the nucleus of the solitary tract and ventrolater...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01222-0
更新日期：1999-01-23 00:00:00
abstract：:Nucleotide-repeat expansions underlie a heterogeneous group of neurodegenerative and neuromuscular disorders for which there are currently no effective therapies. Recently, it was discovered that such repetitive RNA motifs can support translation initiation in the absence of an AUG start codon across a wide variety of...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2016.04.003
更新日期：2016-09-15 00:00:00
abstract：:In the cat, cells of the superior colliculus (SC) and the tectofugal pathways of the visual system are highly selective for the direction of a moving visual stimulus. Deep layer units of SC in addition respond to auditory and somatosensory stimuli, but the proportion of such non-visual cells is usually found to be muc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90430-7
更新日期：1989-06-19 00:00:00
abstract：:The ability of crude cerebrum supernatant to stabilize, at a low temperature, cold-labile microtubules purified from beef brain was studied during development in the rat. The cold-stabilizing activity of the supernatant was low during the first postnatal week, rose significantly during the second postnatal week, and t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90238-6
更新日期：1988-08-01 00:00:00
abstract：:The climbing fiber input to the cerebellar cortex was destroyed using both electrolytic and chemical (3-acetylpyridine) lesions. The long-term effects of climbing fiber deafferentation on the ansiform lobule of weanling and adult rats were examined at both the light and electron microscopic levels. Image analysis of G...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90022-3
更新日期：1986-09-24 00:00:00
abstract：:Noxious stimulation of the leg increases hind limb blood flow (HBF) to the ipsilateral side and decreases to the contralateral in rat. Whether or not this asymmetrical response is due to direct control by sympathetic terminals or mediated by other factors such as local metabolism and hormones remains unclear. The aim ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.03.057
更新日期：2011-05-19 00:00:00
abstract：:In the present research the role of gender in MDMA-induced hyperthermia and serotonin depletion is studied by injecting male and female male rats with MDMA or saline 3 times (i.p.) with 3h interval at dosages of 0.3, 1, 3 or 9 mg/kg at an ambient temperature of 25°C. The acute hyperthermia following the higher dosages...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.04.039
更新日期：2011-06-29 00:00:00
abstract：:Previous research has suggested the potential involvement of the hypothalamic-pituitary-adrenal (HPA) axis in psychostimulant reinforcement. In particular, we have found significant correlations between electric footshock-induced increases in plasma corticosterone and the acquisition, or lack thereof, of intravenous c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00206-5
更新日期：1996-05-25 00:00:00
abstract：:Astrocytes cultured from the brains of neonatal rat pups acquire at least two specializations of intramembrane particle distribution: 'assemblies' and gap junctions. The number and appearance of assemblies in the cultured astrocytes is not markedly influenced by the presence or absence of a collagen substrate, and the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90545-0
更新日期：1983-10-03 00:00:00
abstract：:Hydrogen-rich water (HRW) has anti-oxidant activities, and it exerts neuroprotective effects during ischemia-reperfusion brain injury. Parvalbumin and hippocalcin are two calcium buffering proteins, which are involved in neuronal differentiation, maturation and apoptosis. The aim of this study was to investigate wheth...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.04.038
更新日期：2015-07-30 00:00:00
abstract：:The present study is designed to investigate the effects of preconditioning with different doses of hydrogen peroxide (H2O2) on oxidative stress-induced apoptosis and the changes in mitochondrial membrane potential (MMP), intracellular reactive oxygen species (ROS) level, and expression of Bcl-2 during H2O2 preconditi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.07.072
更新日期：2005-09-28 00:00:00
abstract：:Endothelin (ET), a potent vasoconstrictor peptide, is believed to have central sites of action and potential neurohormonal effects relating to body fluid homeostasis and blood-pressure regulation. Systemic endothelin binds to receptors at circumventricular organs and has been shown to increase plasma concentrations of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90580-3
更新日期：1992-01-20 00:00:00
abstract：:Environmental risk factors such as stressful experiences have long been recognized to affect seizure susceptibility, but little attention has been paid to the potential effects of improving housing conditions. In this study, we investigated the influence of an enriched environment on epileptogenesis. Epileptic suscept...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03355-3
更新日期：2002-11-08 00:00:00
abstract：:Tissue prisms prepared from neurosurgical samples of temporal neocortex of Alzheimer and control patients, upon depolarization preferentially released aspartate, glutamate and gamma-aminobutyrate (GABA). The Alzheimer and control samples did not significantly differ in the pattern of amino acid release, although acety...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91131-9
更新日期：1983-03-28 00:00:00
abstract：:Although there are indications of growth in the size and myelination of the rat corpus callosum during adulthood, it is not known how long this growth continues. In addition, the potential for age-related changes in these measures to affect the sex differences seen in adulthood has not been examined. Here the size of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.01.043
更新日期：2007-04-20 00:00:00
abstract：:Apoptosis has been shown to be induced by some pathological stimuli. MPP+ is a neurotoxin and an inducer of parkinsonism. When SH-SY5Y cells, human neuroblastoma cell line, were treated with MPP+, cell death estimated by lactate dehydrogenase (LDH) leakage assay occurred. The cell death was associated with the DNA fra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01120-x
更新日期：1995-12-18 00:00:00
abstract：:We have studied the modulation of hippocampal neuron morphological development in vitro using surfaces derivatized with aminosilane self-assembled monolayers (SAMs). The efficacies of model SAMs, alone, or in combination with adsorbed heparan sulfate glycosaminoglycan (HS), are related to the physical and chemical pro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90651-3
更新日期：1993-12-10 00:00:00
abstract：:This study addressed the issue of multiple parallel auditory processing systems and their relationship to the skull-recorded auditory evoked potentials (AEPs) in the unanesthetized, unrestrained rat. In the preceding paper (Brain Res., 602 (1993) 240-250) it has been shown that auditory cortex activity does not contri...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90690-o
更新日期：1993-02-05 00:00:00
abstract：:Using previously characterized polyclonal antibody directed against dopamine beta-hydroxylase (DBH), immunoreactive fibers were demonstrable in pineals of 6 controls of various ages and of 3 individuals with Alzheimer's disease (AD). Abnormal, swollen axons were present in pineals from aged individuals and from indivi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90818-4
更新日期：1989-03-06 00:00:00
abstract：:Total weight and DNA (cell number) determination in whole olfactory bulbs (OB) revealed that unilateral transection of the olfactory peduncle in newborn rats causes 2 X more (40%) deficit in cell number in the operated OB than section of the olfactory nerve. The deficit due to combined operations ('isolation' of OB) w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90104-5
更新日期：1986-10-01 00:00:00
abstract：:Choline is an essential nutrient whose availability during the second half of gestation produces long-lasting cognitive effects. Rats that obtain supplemental choline during embryonic day (E) 11-17 have enhanced depolarization-evoked acetylcholine (ACh) release from hippocampal slices, whereas choline deficiency durin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.08.046
更新日期：2008-10-27 00:00:00
abstract：:Short, high frequency stimulation bursts (4 pulses at 100 Hz) were applied to Schaffer/commissural projections to the CA1 field of rat hippocampal slices at 0.1, 0.2, 1.0 or 2.0-s intervals to assess their efficacy in eliciting long-term potentiation (LTP). Bursts repeated at 2-s intervals induced very little LTP; sho...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90579-2
更新日期：1986-03-19 00:00:00
abstract：:This study tested the hypothesis that the short-latency excitation of the phrenic motor output elicited by superior laryngeal nerve (SLN) stimulation requires non-NMDA receptor-mediated neurotransmission in the region of the dorsal respiratory group (DRG) of the adult cat. Injection of the non-NMDA receptor antagonist...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00355-t
更新日期：1995-06-05 00:00:00
abstract：:Release of Ca(2+) from intracellular Ca(2+) stores (ICS) is involved in age-related changes in the induction of long-term potentiation. However, the role of this Ca(2+) source for the increased susceptibility to long-term depression (LTD) with advanced age is unknown. Extracellular excitatory postsynaptic field potent...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.10.023
更新日期：2005-01-07 00:00:00
abstract：:The quantitative 2-[14C]deoxyglucose autoradiographic method was used to study the effects of the acute administration of a sedative anticonvulsant dose of diazepam (2 mg/kg) on rat brain energy metabolism. This benzodiazepine was injected to rats chronically treated for two weeks either by caffeine (10 mg/kg/day) or ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90593-2
更新日期：1987-09-01 00:00:00
abstract：:The growth of corticospinal tract (CST) axons was studied quantitatively at the 7th cervical (C7) and the 4th lumbar (L4) spinal segments in the balb/cByJ mice at the ages of postnatal day (P) 0, 2, 4, 6, 8, 10, 14, and 28. The cross-sectional area of the CST increased progressively with time. Unmyelinated axons, the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.02.036
更新日期：2006-04-21 00:00:00
abstract：:Somatosensory neurons including nociceptive ones in the medial thalamus have been studied extracellularly, and are classified into three types: nociceptive-specific, wide dynamic range, and tap neurons. However, the morphological characteristics of these three neurons have not yet been clarified. We studied the morpho...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91368-o
更新日期：1992-07-17 00:00:00
