Abstract：
:Previous research has suggested the potential involvement of the hypothalamic-pituitary-adrenal (HPA) axis in psychostimulant reinforcement. In particular, we have found significant correlations between electric footshock-induced increases in plasma corticosterone and the acquisition, or lack thereof, of intravenous cocaine self-administration in rats. The experiments presented here were designed to further determine the role for corticosterone in cocaine reinforcement in rats by decreasing plasma levels of the hormone with surgical and pharmacological adrenalectomies. Bilateral adrenalectomy completely abolished the acquisition of intravenous cocaine self-administration over a wide range of doses (0.03125 to 1.0 mg/kg/infusion) without affecting food maintained responding. This suppression of self-administration was partially reversed by adding corticosterone (100 micrograms/ml) to the rats' drinking water. In another group of rats, pretreatment with metyrapone, which blocks the synthesis of corticosterone, resulted in dose-related decreases in ongoing cocaine self-administration. These data suggest that corticosterone is not only important, but may also be necessary for both the acquisition and maintenance of cocaine reinforcement in rats.
journal_name
Brain Resjournal_title
Brain researchauthors
Goeders NE,Guerin GFdoi
10.1016/0006-8993(96)00206-5subject
Has Abstractpub_date
1996-05-25 00:00:00pages
145-52issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(96)00206-5journal_volume
722pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Amitriptyline, a representative tricyclic antidepressant, has been widely used for the treatment of neuropathic pain, such as post-herpetic and trigeminal neuralgia. In the present study, we investigated the effect of amitriptyline on glycinergic spontaneous miniature inhibitory postsynaptic currents (mIPSCs) in acute...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.03.030
更新日期：2012-05-21 00:00:00
abstract：:In seven female alpha-chloralose-anesthetized cats, 52 lateral thalamic neurons were tested with noxious distension of the urinary bladder, the distal colon and the lower esophagus. In addition, the neurons were characterized with innocuous and noxious mechanical stimulation of the skin and deep structures. Of the 52 ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02180-0
更新日期：1999-12-18 00:00:00
abstract：:Long-term potentiation (LTP) can be initiated in CA1, but not in the dentate, region of slices from rats with bilateral subcortical deafferentation at 8 week survival time. At about one week survival time, LTP is present in the CA1 region of all and also in the dentate of about 50% of slices. The results suggest that ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90981-g
更新日期：1990-06-04 00:00:00
abstract：:The development of glial precursor cells in the mammalian optic nerve depends on retinal ganglion cell (RGC) axons, but the signals that mediate this neuron-to-glia interaction have not been fully characterized. Sonic hedgehog (Shh) is expressed by RGCs, and we showed previously that it is required for the specificati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.06.058
更新日期：2008-09-04 00:00:00
abstract：:Intracellular and extracellular recordings in the arterially-perfused eye cup of pigmented and albino rabbits show the presence of blue cones, green cones and rods. Among the ganglion cells, a fraction shows spectral opponency. Two main types were found. In one, on-depolarizing responses and on-hyperpolarizing respons...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90278-0
更新日期：1978-07-14 00:00:00
abstract：:The effects of diethyldithiocarbamate (DDC) and DDC plus glutamate on mesencephalic cell cultures were investigated. DDC 10 microM was toxic for cell cultures as assessed by observation under a phase-contrast microscope and the drop in [3H]dopamine uptake. Moreover, DDC 1 microM greatly potentiated cell death induced ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01457-s
更新日期：1995-03-13 00:00:00
abstract：:A single informon reproduces classical conditioning to compound stimuli under a wide range of conditions during reinforcement and non-reinforcement; it also reproduces simple operant conditioning. A network of 210 informons with 8400 simultaneouslly varying pathways has been simulated; it can learn to recognize handpr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90574-6
更新日期：1976-01-30 00:00:00
abstract：:Changes in absorbance of voltage-sensitive merocyanine-rhodanine dyes were used to monitor electrical responses in the semilunar ganglion of 4-10-day-old developing chick embryos. The electrical responses were simultaneously recorded from many positions in the ganglion. Stimulation of the afferent nerve fibers (the op...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90130-0
更新日期：1985-01-01 00:00:00
abstract：:Antimitotic drugs used in the chemotherapeutic treatment of cancers induce undesirable but unavoidable side-effects from interruption of normal mitotic processes throughout the body. We have examined whether several such drugs capable of penetrating the blood-brain barrier - thioTEPA and 5-fluorouracil - influence the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.06.093
更新日期：2006-09-21 00:00:00
abstract：:The purpose of the present study was to investigate the possible involvement of hippocampal NMDA (N-methyl-d-aspartate) receptors in spatial memory in rats by means of intrahippocampal injection of an NMDA antagonist, AP5 (D,L-2-amino-5-phosphonopentanoic acid). In Expt. 1, spontaneous motor activity (locomotor activi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01256-0
更新日期：1998-01-19 00:00:00
abstract：:The serotonin agonist 8-hydroxy-di-propylaminotetralin (8-OH-DPAT), injected systemically or directly into the medial preoptic area (MPOA), reduces the ejaculatory threshold in male rats. While 8-OH-DPAT has been characterized as an agonist at the 5-HT1A receptor, it also acts at other receptor sites including the dop...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01331-6
更新日期：1999-02-27 00:00:00
abstract：:The present study examined the locomotor response of rats to unilateral injections of the mixed D1/D2 agonist apomorphine, the D2 agonist quinpirole, and the D1 agonist SKF 38393 into the left or right nucleus accumbens (NA) of male Sprague-Dawley rats. There were 2 main findings. First, unilateral (left or right) inj...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91351-g
更新日期：1990-11-19 00:00:00
abstract：:Social plasticity is the ability to adaptively change the expression of social behaviour according to experience, allowing animals to optimize their social relationships in the context of previous experience and the complexities of social environments. Environmental enrichment (EE) mimics a stimulating lifestyle at th...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2019.03.033
更新日期：2019-08-15 00:00:00
abstract：:The cellular and intracellular localization of the epsilon-subspecies of protein kinase C (PKC) in the rat brain was demonstrated by immunocytochemistry using specific antibodies against epsilon-PKC. The epsilon-PKC-specific immunoreactivity was most abundant in the hippocampal formation, olfactory tubercle and Callej...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91512-q
更新日期：1993-04-02 00:00:00
abstract：:Chronic food restriction lowers the threshold for lateral hypothalamic electrical self-stimulation (LHSS). This effect has previously been interpreted to reflect a sensitization of reward. In the present study a curve-shift method was used to explicitly differentiate effects of food restriction on brain stimulation re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00764-h
更新日期：1995-10-16 00:00:00
abstract：:The distribution of neural elements immunoreactive to several peptides with a possible messenger role was studied in the lamprey spinal cord by using an indirect immunofluorescence method. Different patterns of immunoreactive (IR) fibers were detected by antisera raised against cholecystokinin, metorphamide, bombesin,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90392-1
更新日期：1987-04-07 00:00:00
abstract：:The properties of 5 beta-reductase, 5 alpha-reductase and aromatase, 3 testosterone metabolizing enzymes, were studied in the quail brain by an in vitro incubation technique. The results describe the changes in time of metabolite production and the effects of temperature, enzyme and cofactor concentrations. The appare...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91118-1
更新日期：1984-07-02 00:00:00
abstract：:The action of gamma-aminobutyric acid (GABA) in the supraoptic nucleus was investigated using guinea pig brain slices. GABA produced a membrane depolarization accompanied by a decrease in the input resistance. The action of GABA was concentration-dependent throughout a wide range of concentrations (10(-7)-10(-3) M). I...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90059-x
更新日期：1987-02-17 00:00:00
abstract：:The distribution of iron in the brain of a vocal learning parrot, the budgerigar (Melopsittacus undulatus), was examined using iron histochemistry. In mammals, iron is a highly specific stain for the dorsal and ventral pallidal subdivision as well as specific cell groups in the brainstem, including the substantia nigr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03110-9
更新日期：2001-12-07 00:00:00
abstract：:Retinal lesions in pigeons produced a marked depletion of somata and neuropil staining for both calbindin-D28k and parvalbumin immunoreactivities in the contralateral optic tectum. Calbindin-like immunoreactivity reappeared in some tectal layers by 6 weeks postlesion, whereas paravalbumin-like immunoreactivity recover...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91206-8
更新日期：1994-10-24 00:00:00
abstract：:The actions of convulsant and sedative barbiturates on responses to gamma-aminobutyric acid (GABA) application and on inhibitory postsynaptic currents were compared using voltage-clamp techniques in cultured rat hippocampal neurons. The convulsant barbiturates, 5-ethyl-5-(3-methylbut-2-enyl) barbituric acid (3M2B), an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90910-4
更新日期：1990-05-14 00:00:00
abstract：:Antisense oligodeoxynucleotide (AS ODN) probes directed against the alpha-subunit of different G-proteins have been used to differentiate feeding responses in rats elicited by different opioid agonists, including morphine, beta-endorphin and dynorphin. Furthermore, antisense probes directed against G(o)alpha, but not ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03361-9
更新日期：2002-11-15 00:00:00
abstract：:The effect of the non-competitive N-methyl-D-aspartate antagonist MK-801 on the early development of kindling-induced potentiation was examined in the rabbit hippocampal dentate gyrus. MK-801 (0.5 mg/kg) was administered 2 h before each daily kindling stimulation was applied to the perforant path. This treatment conti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91182-z
更新日期：1991-10-18 00:00:00
abstract：:Nerve fibers containing 5-hydroxytryptamine (5-HT) were demonstrated immunohistochemically in the wall of pial vessels associated with the circle of Willis in the guinea pig. The fibers formed a network structure which was more dense in the rostral part of the arterial circle and its branches than in the caudal part. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91342-x
更新日期：1988-01-12 00:00:00
abstract：:Ca2+-permeable AMPA receptors (AMPAR) which crucially modify maturational programs of the developing brain are involved in seizure-induced glutamate excitotoxicity and apoptosis. Regulatory effects on AMPAR subunit composition and RNA-editing in the developing brain and their significance as therapeutic targets are no...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.146760
更新日期：2020-05-15 00:00:00
abstract：:In view of the use of synthetic propentofylline (PPF) as a protective agent in brain ischemia, its possible side effects on vision capacities have been explored by electroretinography in comparative experiments with theophylline. We used eyecup preparations of small-spotted dogfish sharks and of European eels, particu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02328-3
更新日期：2000-06-23 00:00:00
abstract：:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces dopaminergic neuron death in substantia nigra and dopamine loss in striatum, similar to those observed in Parkinson disease. Given MPTP can also induce alterations in brain cytokines and in peripheral immune parameters, we hypothesize that MPTP can induce an ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.03.009
更新日期：2005-05-31 00:00:00
abstract：:The pathological process in Alzheimer's disease (AD) involves amyloid beta (Abeta) deposition and neuronal cell degeneration. The neurotoxic Abeta peptide is derived from the amyloid precursor protein (APP), a member of a larger gene family including the amyloid precursor-like proteins, APLP1 and APLP2. The APP and AP...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01861-2
更新日期：1999-09-25 00:00:00
abstract：:Serum-free aggregating cell cultures of fetal rat telencephalon grown in the presence of 3 ng/ml (5 X 10(-10) M) epidermal growth factor (EGF) until day 12 showed 2- to 3-fold increased activities in the two glial enzymes, glutamine synthetase (GLU-S) and 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNPase). This effe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90222-5
更新日期：1983-12-01 00:00:00
abstract：:The relationship between seizure propensity and the vascular anatomy of the anterior cerebral arteries, or stroke induced by unilateral ligation of the common carotid artery, was investigated utilizing well differentiated colonies of seizure-prone (SP) and non-seizure-prone (NSP) gerbils. Twenty SP and 20 NSP gerbils ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90867-8
更新日期：1982-02-25 00:00:00
