Abstract：
:Antimitotic drugs used in the chemotherapeutic treatment of cancers induce undesirable but unavoidable side-effects from interruption of normal mitotic processes throughout the body. We have examined whether several such drugs capable of penetrating the blood-brain barrier - thioTEPA and 5-fluorouracil - influence the normal process of cell proliferation underlying neurogenesis in the dentate gyrus of the hippocampus of mice. thioTEPA was found to yield a pronounced dose-related inhibition in cell proliferation, while 5-fluorouracil did not. The magnitude of the inhibition paired with a lack of observable impairment of health in mice indicates a suitable experimental model for elucidating the contributions of hippocampal cell proliferation to cognition and behavior.
journal_name
Brain Resjournal_title
Brain researchauthors
Mignone RG,Weber ETdoi
10.1016/j.brainres.2006.06.093subject
Has Abstractpub_date
2006-09-21 00:00:00pages
26-9issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(06)02003-8journal_volume
1111pub_type
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