Abstract：
:In view of the use of synthetic propentofylline (PPF) as a protective agent in brain ischemia, its possible side effects on vision capacities have been explored by electroretinography in comparative experiments with theophylline. We used eyecup preparations of small-spotted dogfish sharks and of European eels, particularly suitable for long-lasting experiments. The drug exerted profound but reversible modifications of ERG records: (1) a dose-dependent increase of the amplitude and duration of the chemically isolated late receptor potential (LRP), (2) a partial unmasking of LRP, (3) a strong potentiation of the LRP-unmasking effect of low temperature, (4) a potentiation of light adaptation effects, and (5) a strong potentiation of the post-illumination hyperexcitability. The effects were explicable as due to a strong phosphodiesterase (PDE) inhibiting, cyclic guanosine monophosphate (cGMP) promoting, action of the drug. The effects were considerably stronger, or even of opposite sign, in comparison to those of the chemically related theophylline. PPF did not seriously affect the ERG c-wave originating in the pigment epithelium. The results suggested that the effects of PPF on vision may not seriously hamper the therapeutic use of the drug. They indicated, on the other hand, that PPF was a retinoactive drug of potential usefulness in the exploration of the complex biochemical events underlying visual transduction.
journal_name
Brain Resjournal_title
Brain researchauthors
Andjus RK,Konjević D,Damjanović I,Gacić Zdoi
10.1016/s0006-8993(00)02328-3subject
Has Abstractpub_date
2000-06-23 00:00:00pages
176-90issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(00)02328-3journal_volume
868pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:In animal models, the hallmark of a hypoxic condition is a strong negative shift of the DC potential (anoxic terminal negativity, ATN). This DC-shift is interpreted to be primarily due to a breakdown of the membrane potential of neurons. Such massive neuronal depolarizations have not been reported for all human neocor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)00911-0
更新日期：1996-11-25 00:00:00
abstract：:Previous studies in our laboratory using rat brain tissue have shown that neuropeptide Y (NPY) can enhance NMDA- and potassium-stimulated dopamine release from various brain regions and that this enhancement is reversed by sigma (sigma) receptor antagonists. In the current study, we sought to determine whether SH-SY5Y...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02722-0
更新日期：2000-09-22 00:00:00
abstract：:A progressive model of Parkinson's disease has been recently developed in the rat where a unilateral excitotoxic injection into the globus pallidus leads to a gradual loss of dopaminergic neurons in the ipsilateral substantia nigra over a period of at least 6 weeks. In this model microglial activation is observed in t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.04.020
更新日期：2008-06-24 00:00:00
abstract：:The aim of this study was to examine the involvement of the hypothalamic oxytocin (OXT) and vasopressin (AVP) neurons in acute phase reaction using quantitative dual-labeled immunostaining with Fos and either OXT and AVP in several hypothalamic regions. Administration of low dose (5 microg/kg) and high dose (125 micro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02418-x
更新日期：2000-03-06 00:00:00
abstract：:Administration of vitamin B12 (VB12) has been reported to normalize human sleep-wake rhythm disorders such as non-24-h sleep-wake syndrome (HNS), delayed sleep phase syndrome (DSPS) or insomnia. However, the mechanisms of the action of VB12 on the rhythm disorders are unknown. In the present study, therefore, effects ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00349-6
更新日期：1996-07-15 00:00:00
abstract：:Morphological alterations occurring in Schwann cells of unmyelinated fibers (unmyelinated Schwann cells) were investigated in the sciatic nerve of the twicher mouse, a murine model of human globoid cell leukodystrophy. After postnatal day 10, the number of Schwann cell-axon units gradually increased and the number of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91719-8
更新日期：1989-11-27 00:00:00
abstract：:Rats with electrodes in either the posterior medial forebrain bundle (MFB), the anterior MFB, the medial prefrontal cortex, or the locus coeruleus self-stimulated during a 45 min period following the injection of [14C]2-deoxyglucose. They were then sacrificed and their brains prepared for autoradiography. The autoradi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91307-0
更新日期：1983-04-25 00:00:00
abstract：:In adult female rats, estrogen receptor (ER) activation, particularly of ERbeta, promotes hippocampal neurogenesis. We previously reported that extranuclear ERbeta immunoreactivity (ir) in adult rats is on cellular profiles in or near the granule cell layer, which is the location of newly generated cells. During devel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.08.084
更新日期：2006-11-22 00:00:00
abstract：:[3H]Paroxetine binding to human brain tissue was characterized. Competition studies in the putamen and frontal cortex revealed single-site binding models for binding sensitive to 5-hydroxytryptamine (5-HT) (Ki 1-3 microM) and citalopram (Ki 0.6 nM), which displaced the same amount of binding. However, desipramine, nor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90511-8
更新日期：1989-05-08 00:00:00
abstract：:Dorsal root ganglion (DRG) neurons from rat embryos were explanted either alone or with the attached spinal cord (SC). Neuritic processes were mapped out histologically using an intracellular iontophoretic HRP method. Computer reconstructions and morphometric parameters allowed a comparative quantitative analysis of t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90871-6
更新日期：1992-07-03 00:00:00
abstract：:Metabotropic glutamate receptors (mGluRs) are thought to mediate diverse processes in brain including synaptic plasticity and excitotoxicity. These receptors are often divided into three groups by their pharmacological profiles. [3H]Glutamate binding in the presence of compounds selective for ionotropic glutamate rece...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00818-4
更新日期：1997-10-31 00:00:00
abstract：:The septo-hippocampal pathway contains a major gamma-aminobutyric acid (GABA) projection to dendritic fields within the hippocampus. To determine the importance of the septo-hippocampal pathway in ischemia-induced accumulation of GABA and subsequent cell death in area CA1 of hippocampus, septo-hippocampal deafferentat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01415-7
更新日期：1998-03-02 00:00:00
abstract：:Temperature dysregulation is well known in generalized convulsive status epilepticus but so far has not been reported in non-convulsive forms. In order to detect possible subtle alterations, we have analyzed the capability to compensate for external cooling in an animal model of limbic status epilepticus. Rats with el...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.10.034
更新日期：2007-01-05 00:00:00
abstract：:Early brain injury (EBI) plays a pivotal role in the prognosis of patients with subarachnoid haemorrhage (SAH). Dexmedetomidine (DEX), a highly selective α2 receptor agonist, is reported to exert multiple protective effects in many neurological diseases. This study was designed to investigate whether DEX had neuroprot...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.05.040
更新日期：2018-11-01 00:00:00
abstract：:The effects of medial septal lesions on latent inhibition (LI) were assessed in a conditioned taste aversion paradigm. Animals were tested in a LI paradigm 2 weeks after receiving medial septal or sham lesions. The LI paradigm involved a pre-exposure phase in which water-deprived rats were allowed access to either wat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03192-9
更新日期：2001-02-02 00:00:00
abstract：:Calretinin and calbindin-D28k are two calcium-binding proteins which are present in separate populations of interneurons in cerebral cortex and hippocampus. To identify these cells with the populations expressing different transmitters, two-colour immunofluorescence was done with antibodies against the calcium-binding...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91439-l
更新日期：1992-07-31 00:00:00
abstract：:The effects of amphetamine were examined in a brain stimulation reward paradigm in which response rate was measured across a range of stimulation frequencies. Both low (0.0625 and 0.125 mg/kg) and high (1.0, 2.0 and 4.0 mg/kg) doses of systemic amphetamine decreased the stimulation frequency needed to sustain low rate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90653-1
更新日期：1988-09-06 00:00:00
abstract：:As a model of chronic inflammatory pain, Freund's adjuvant-induced polyarthritis has been shown to be associated with marked alterations in the activity of opioid- and calcitonin gene-related peptide (CGRP)-containing neurons in the dorsal horn of the spinal cord in rats. Possible changes in the interactions between t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00350-3
更新日期：1998-06-15 00:00:00
abstract：:Neonatal rats were given capsaicin subcutaneously. Controls received vehicle only. Six months later the nerve fiber populations in the dorsal root L4, in the inferior alveolar nerve and in mandibular molar pulps were examined by electron microscopy. The proportion of unmyelinated axons was found to be markedly decreas...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91315-x
更新日期：1983-04-25 00:00:00
abstract：:There is a strong link between cognitive impairment and depression, but up to date it is not clear whether cognitive impairment is 'cause' or 'consequence' of depression. Therefore, we here examined the effect of cognitive impairment induced by permanent occlusion of common carotid arteries, a model known as two-vesse...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.09.056
更新日期：2015-01-30 00:00:00
abstract：:The anterograde neuronal tracing properties of Fluoro-Gold (FG) were characterized in this study by its ability to label the retinohypothalamic tract (RHT) upon pressure injection of the substance into the vitrous body of the eye in the Djungarian hamster, Phodopus sungorus. Tracing was compared to the anterograde neu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01151-1
更新日期：1997-01-16 00:00:00
abstract：:Effects of iontophoretically applied dopamine were investigated in prefrontal neurons of the monkey which showed activity changes during a visual reaction time task. The task consisted of an initial waiting phase (3.0 s), a warning phase (green lamp, 1.5-3.5 s), a lever-release GO phase (red lamp) and a reward phase. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90385-9
更新日期：1986-04-23 00:00:00
abstract：:In the context of injury to the corticospinal tract (CST), brainstem-origin circuits may provide an alternative system of descending motor influence. However, subcortical circuits are largely under subconscious control. To improve volitional control over spared fibers after CST injury, we hypothesized that a combinati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.07.012
更新日期：2013-11-13 00:00:00
abstract：:Acetylcholinesterase (AChE) histochemical staining occurred in neurons of the dentate gyrus at the day of birth and steadily increased in intensity and distribution during the first 3 postnatal weeks until the adult pattern was reached. Granule cells failed to display AChE staining; however, the somata of most non-pri...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90072-1
更新日期：1987-11-01 00:00:00
abstract：:Astrocytic gap junctions have been implicated in a variety of signaling pathways essential to normal brain function. However, no information exists on the prevalence of gap junction channels and their function in the aging brain. Here we have compared the expression of the two most abundant astrocytic gap junction pro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02258-2
更新日期：2001-05-18 00:00:00
abstract：:The response of noradrenergic (NE), serotonergic (5-HT), and dopaminergic (DA), neurons to repeated presentations (once/2 s for 64 trials) of phasic auditory (click) and visual (flash) stimuli was examined in freely moving cats. All 3 groups of neurons displayed similar response latencies and somewhat similar duration...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90546-9
更新日期：1986-03-26 00:00:00
abstract：:The acute effects of ethanol on the gamma-aminobutyric acid (GABA)-activated current were studied with the rat dorsal root ganglion neurons in primary culture using the whole-cell patch-clamp technique. GABA produced an inward chloride current, which was composed of an initial transient and a subsequent sustained phas...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90982-h
更新日期：1990-06-04 00:00:00
abstract：:In the present study, we characterized the evoked electrical activity from T(13) to S(2) dorsal roots (DRs) during glass probe-stimulation of the vagina-cervix-uterus junction (VCUJ) of female Wistar rats. The results showed that gentle stimulation of VCUJ evoked high-amplitude electrical activity in L(3) and L(6) DRs...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.12.023
更新日期：2013-02-16 00:00:00
abstract：:Dopaminergic and glutamatergic afferents simultaneously innervate median spiny neurons (MSNs) and interact to mediate basal ganglia functions. However, the association between dopaminergic and glutamatergic axons is not clear. In the present study, nigrostriatal, corticostriatal, and thalamostriatal axons were anterog...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.09.032
更新日期：2012-11-27 00:00:00
abstract：:The optic nerve of anesthetized cats was completely cut and the autologous sciatic nerve was transplanted. Sixty days later some populations of retinal ganglion cells were shown to regenerate the axon with retrograde HRP labeling. We verified that ganglion cells that had projected to the lateral geniculate nucleus (LG...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91253-w
更新日期：1991-09-27 00:00:00
