Depletion and recovery of the calcium-binding proteins calbindin and parvalbumin in the pigeon optic tectum following retinal lesions.

abstract：:Aging represents a major risk factor for numerous illnesses that are of increasing importance to society, including two of the most prevalent: diabetes and Alzheimer's disease. Studies have shown that diabetes is a risk factor for spontaneous Alzheimer's disease. While these studies suggest that diabetes can contribut...

journal_title：Brain research

authors： Oliveira LT,Leon GVO,Provance DW Jr,de Mello FG,Sorenson MM,Salerno VP

更新日期：2015-07-30 00:00:00

abstract：:Immunohistochemical localization of the decapeptide gonadotropin releasing hormone (GnRH) in neural structures in the pony brain and infundibulum (INF) was conducted at the light-microscopic level. This procedure utilized an antiserum generated against GnRH conjugated to bovine serum albumin. In the rostral INF, GnRH ...

journal_title：Brain research

authors： Dees WL,Sorensen AM Jr,Kemp WM,McArthur NH

更新日期：1981-03-09 00:00:00

abstract：:Interactions between brain alpha2- and beta-adrenoceptors are of interest in physiological (aging) and pathological (major depression) processes involving both receptors. In this study, total beta-adrenoceptors and beta1/2-subtypes were quantitated in postmortem human brains to investigate their relationships with alp...

journal_title：Brain research

authors： Sastre M,Guimón J,García-Sevilla JA

更新日期：2001-04-20 00:00:00

abstract：:Amacrine cells are axonless interneurons of the vertebrate retina. Over the past few years many neuroactive peptides have been localized to these cells. We have previously demonstrated that a neuropeptide and a classical transmitter are colocalized in some amacrine cells. In this report, we show that two neuroactive p...

journal_title：Brain research

authors： Li HB,Watt CB,Lam DM

更新日期：1985-10-14 00:00:00

abstract：:Increased neurogenesis by promoting proliferation of neural precursor cells in the adult dentate gyrus might be beneficial for the treatment of psychiatric disorders. Results demonstrate that bFGF is necessary for the proliferation of neural precursor cells and that the glycogen synthase kinase-3β (GSK-3β) and β-caten...

journal_title：Brain research

authors： Boku S,Nakagawa S,Toda H,Kato A,Takamura N,Omiya Y,Inoue T,Koyama T

更新日期：2013-01-25 00:00:00

abstract：:Tetanic stimulation at 50 Hz elicited long-term potentiation (LTP) in the hippocampal CA1 region of 28-day-old control animals. In contrast, no significant potentiation was seen following the same tetanus in animals chronically exposed to 1000 ppm of lead acetate during development. Gender differences were observed in...

journal_title：Brain research

authors： Zaiser AE,Miletic V

更新日期：2000-09-08 00:00:00

abstract：:Because previous studies have emphasized the importance of the amygdala in the therapeutic actions of benzodiazepines and described differences in benzodiazepine receptor distribution between human and rat, this study examined the distribution of multiple benzodiazepine receptors in normal human amygdala by light micr...

journal_title：Brain research

authors： Niehoff DL,Whitehouse PJ

更新日期：1983-10-16 00:00:00

abstract：:Previous studies have shown that muscarinic cholinergic agonists bind to 3 distinct receptor sites in brain, each being distinguished by their affinity for the agonists. Antagonists, on the other hand, bind to these sites with the same high affinity. The relative concentrations of the two high and the low affinity ago...

journal_title：Brain research

authors： Wamsley JK,Zarbin MA,Birdsall NJ,Kuhar MJ

更新日期：1980-10-27 00:00:00

abstract：:Hyperprolinemia type II is an autosomal recessive disorder caused by the severe deficiency of delta(1)-pyrroline-5-carboxylate dehydrogenase activity leading to tissue accumulation of proline (Pro). Most patients detected so far show neurological manifestations including epilepsy and mental retardation, whose pathophy...

journal_title：Brain research

authors： Delwing D,Bavaresco CS,Chiarani F,Wannmacher CM,Wajner M,Dutra-Filho CS,de Souza Wyse AT

更新日期：2003-11-21 00:00:00

abstract：:As a first step in understanding the function of the 68-kDa Alz-50 antigen (A68) in the pathophysiology of Alzheimer's disease (AD), we have reexamined preliminary observations in our laboratory (Wolozin and Davies, 1986) of a protein kinase activity associated with crude preparations of the protein. This study was un...

journal_title：Brain research

authors： Vincent IJ,Davies P

更新日期：1990-10-29 00:00:00

abstract：:Many phosphorylated extracellular signal-regulated kinase (pERK)-immunoreactive (IR) cells are expressed in the trigeminal spinal subnucleus caudalis (Vc), upper cervical spinal cord (C1-C2), nucleus tractus solitarii (NTS) and paratrigeminal nucleus (Pa5) after capsaicin injection into the whisker pad (WP), masseter ...

journal_title：Brain research

authors： Tsujimura T,Shinoda M,Honda K,Hitomi S,Kiyomoto M,Matsuura S,Katagiri A,Tsuji K,Inoue M,Shiga Y,Iwata K

更新日期：2011-10-12 00:00:00

abstract：:Both nictitating membrane extension and eyelid EMG activity were measured during classical conditioning of rabbits to tone-airpuff pairings. Both measures were highly correlated. Over trials, learning criterion was met earlier with eyelid EMG activity than with nictitating membrane extension. Within a trial, eyelid EM...

journal_title：Brain research

authors： Lavond DG,Logan CG,Sohn JH,Garner WD,Kanzawa SA

更新日期：1990-04-30 00:00:00

abstract：:The luteinizing hormone-releasing hormone (LHRH) system of the platyfish Xiphophorus has been studied using immunohistochemistry and retrograde transport of horseradish peroxidase (HRP). Three different populations of LHRH-positive cell bodies are present in the brain, one in the ventral telencephalon at the border to...

journal_title：Brain research

authors： Münz H,Stumpf WE,Jennes L

更新日期：1981-09-21 00:00:00

abstract：:Geranylgeranylacetone (GGA), more commonly known as an antiulcer agent, reportedly induces the heat shock protein 70 (HSP70) family in the gastric mucosa, liver and heart of rats. However, it has not been reported whether HSPs, and other factors that contribute to neuroprotection, are inducible in the brain following ...

journal_title：Brain research

authors： Fujiki M,Kobayashi H,Abe T,Ishii K

更新日期：2003-11-21 00:00:00

abstract：:The present study determined whether cortical cholinergic neurons recover functionally following the loss of afferent projections from the nucleus basalis magnocellularis (nbm). At various time points following ibotenic acid lesions of the nbm, choline acetyltransferase (ChAT) activity or the capacity of cortical chol...

journal_title：Brain research

authors： Lapchak PA,Araujo DM,Pasinetti G,Hefti F

更新日期：1993-06-11 00:00:00

abstract：:We quantified by microdensitometry the immunoreactivity (IR) to monoclonal antibodies (SP6, SP12, SP15 and SP18) against various synaptic proteins in the molecular layers of the dentate gyrus, CA4, CA3, CA1, subiculum and entorhinal cortex in Alzheimer's disease (AD), Lewy body variant of AD (LBV) and diffuse Lewy bod...

journal_title：Brain research

authors： Wakabayashi K,Honer WG,Masliah E

更新日期：1994-12-19 00:00:00

abstract：:The independent and combined effects of Ca2+, Mg2+, Zn2+, Al3+ and Li+ on [3H]MK-801 binding in human cerebral cortical membranes were studied to further characterize the modulatory effects of metal ions on the N-methyl-D-aspartate (NMDA) receptor-ionophore. Glycine, in the presence of glutamate, significantly intensi...

journal_title：Brain research

authors： Hubbard CM,Redpath GT,Macdonald TL,VandenBerg SR

更新日期：1989-05-01 00:00:00

abstract：:Many parts of the brainstem are known to be innervated by the cholinergic neurons of the pontomesencephalic tegmentum, but other possible sources of this innervation have rarely been considered. We sought to examine whether other cells in the brainstem were responsible for this cholinergic input using axonal tract tra...

journal_title：Brain research

authors： Sherriff FE,Henderson Z

更新日期：1994-02-04 00:00:00

abstract：:This study was designed to evaluate the functional significance of angiotensin II (Ang II) receptors identified by previous receptor autoradiography studies to be located presynaptically on terminals of dopaminergic neurones projecting to the striatum. Microdialysis was performed in the striatum of conscious freely mo...

journal_title：Brain research

authors： Mendelsohn FA,Jenkins TA,Berkovic SF

更新日期：1993-06-11 00:00:00

abstract：:Insulin-like 6 immunoreactivity (irINSL6) was detected in Leydig cells of the mouse testis. In the brain, labeled somata were detected mainly in the caudal hypothalamus and midbrain. Double labeling the brainstem sections revealed that irINSL6 somata were 5-hydroxytryptamine (5-HT) positive. The presence of irINSL6 in...

journal_title：Brain research

authors： Brailoiu GC,Dun SL,Yin D,Yang J,Chang JK,Dun NJ

更新日期：2005-04-08 00:00:00

abstract：:As an approach to understanding why central neurons fail to regenerate, we have studied the response to proximal axotomy of transcallosal neurons of the cerebral cortex of the mouse. Anatomical studies have indicated only very slight regenerative responses by this population of cortical neurons. To further examine the...

journal_title：Brain research

authors： Elliott EJ,Parks DA,Fishman PS

更新日期：1997-05-02 00:00:00

abstract：:Six cats were trained to eat while partially restrained and while thermal pulse stimuli (43-60 degrees C, 5 s duration) were delivered to the upper hindlimbs. Food and stimulus delivery were under programmed electronic control. The probability and latency of 3 natural, unlearned nocifensive behaviors were electronical...

journal_title：Brain research

authors： Casey KL,Morrow TJ

更新日期：1989-10-30 00:00:00

abstract：:The serotoninergic (5-hydroxytryptamine, 5-HT) innervation of the rat ventral tegmental area (VTA) was examined by light and electron microscopic radioautography following intraventricular infusion of [3H]5-HT. The [3H]5-HT labeled processes were characterized with respect to their regional distribution, ultrastructur...

journal_title：Brain research

authors： Hervé D,Pickel VM,Joh TH,Beaudet A

更新日期：1987-12-01 00:00:00

abstract：:Neurotrophic factors (NTFs), beside regulating neuronal survival in the central and peripheral nervous system, are also involved in the modulation of neuronal function in the adult animal. Both brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor (GDNF) levels are altered in pathological...

journal_title：Brain research

authors： Ciobanu C,Reid G,Babes A

更新日期：2009-08-11 00:00:00

abstract：:Obesity and related metabolic disorders are important side effects of some antipsychotic drugs (APs). The currently available animal model of AP-induced bodyweight gain (BWG) in rats is based on administration of sulpiride (SUL). However, this model has important limitations. For example, SUL is a pure dopamine antago...

journal_title：Brain research

authors： Baptista T,Araujo de Baptista E,Ying Kin NM,Beaulieu S,Walker D,Joober R,Lalonde J,Richard D

更新日期：2002-12-06 00:00:00

abstract：:We have used magnetic resonance imaging (MRI) of the living rat brain to longitudinally analyze the ontogenesis of an ibotenic acid lesion targeted at the piriform cortex. The MRI data were systematically compared with data obtained from a battery of histopathological techniques, including Nissl stain, hematoxylin sta...

journal_title：Brain research

authors： Ben-Horin N,Hazvi S,Bendel P,Schul R

更新日期：1996-04-29 00:00:00

abstract：:Rabbits reared from birth in stroboscopic illumination have no experience of visual motion. In primary visual cortex of these animals there is a large reduction in the number of cells which are direction selective. This result, contrary to previous reports, shows that the rabbit visual system can be modified by early ...

journal_title：Brain research

authors： Pearson HE,Berman N,Murphy EH

更新日期：1981-01-01 00:00:00

abstract：:The dorsal root ganglia (DRG) have been identified as the target tissue in diabetic somatosensory neuropathy. It has been reported that, in the chronically diabetic state, DRG sensory neurons may undergo morphological changes. In this study, we examined the effect of zenarestat, an aldose reductase inhibitor, on the m...

journal_title：Brain research

authors： Shimoshige Y,Minoura K,Matsuoka N,Takakura S,Mutoh S,Kamijo M

更新日期：2009-01-09 00:00:00

abstract：:Serotonin (5HT) systems play important roles in brain development, and early perturbations of 5HT receptor expression produce permanent changes in 5HT synaptic function and associated behaviors. We exposed pregnant Rhesus monkeys to environmental tobacco smoke (ETS) during gestation and for up to 3 months postnatally ...

journal_title：Brain research

authors： Slotkin TA,Pinkerton KE,Tate CA,Seidler FJ

更新日期：2006-09-21 00:00:00

abstract：:Central activation of excitatory amino acid receptors has been implicated in neuropathic pain following nerve injury. In a rat model of painful peripheral mononeuropathy, we compared the effects of non-competitive NMDA receptor antagonists (MK 801 and HA966) and a non-NMDA receptor antagonist (CNQX) on induction and m...

journal_title：Brain research

authors： Mao J,Price DD,Hayes RL,Lu J,Mayer DJ

更新日期：1992-12-11 00:00:00