Thirteen-month inhibition of aldose reductase by zenarestat prevents morphological abnormalities in the dorsal root ganglia of streptozotocin-induced diabetic rats.


:The dorsal root ganglia (DRG) have been identified as the target tissue in diabetic somatosensory neuropathy. It has been reported that, in the chronically diabetic state, DRG sensory neurons may undergo morphological changes. In this study, we examined the effect of zenarestat, an aldose reductase inhibitor, on the morphological derangement of the DRG and the sural nerve of streptozotocin-induced diabetic rats (STZ rats) over a 13-month period. The cell area of the DRG in STZ rats was smaller than that in normal rats. A decrease in fiber size was apparent in the sural nerve of the STZ rats, and the fiber density was greater. These morphological changes were reversed in zenarestat-treated STZ rats. The data suggest that, in peripheral sensory diabetic neuropathy, hyperactivation of the polyol pathway induces abnormalities not only in peripheral nerve fiber, but also in the DRG, which is an aggregate of primary sensory afferent cell bodies.


Brain Res


Brain research


Shimoshige Y,Minoura K,Matsuoka N,Takakura S,Mutoh S,Kamijo M




Has Abstract


2009-01-09 00:00:00












  • Effects of para-chloroamphetamine upon the serotonergic innervation of the rat hippocampus.

    abstract::The ability of hippocampal serotonergic (5-HT) axons to proliferate in response to damage by para-chloroamphetamine (PCA) was examined in this study. Synaptosomal uptake of 5-HT in the hippocampal formation was decreased to 40% of control 3 days after systemic administration of PCA. Six weeks after PCA, uptake values ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Haring JH,Meyerson L,Hoffman TL

    更新日期:1992-04-17 00:00:00

  • Photoperiodic dependent changes in the number of neurons containing mRNA encoding neuropeptide Y in the intergeniculate leaflet of the Syrian hamster.

    abstract::The intergeniculate leaflet (IGL) is a distinct division of the lateral geniculate complex that participates in the regulation of the circadian rhythm through its projections to the circadian pacemaker located in the suprachiasmatic nuclei of the hypothalamus. A high number of neuropeptide Y (NPY) cell bodies has been...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Jacob N,Vuillez P,Moller M,Pévet P

    更新日期:1998-11-30 00:00:00

  • Embryonic retinal grafts have a beneficial effect on the damaged host retina.

    abstract::The adult rat retina was evaluated following surgical lesion and after transplantation of embryonic day 15 (E15) retinal tissue. While a surgical incision caused degeneration and ganglion cell death peripheral to lesion site, the addition of an embryonic retinal implant to the lesion site resulted in a reduction of th...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Laedtke TW,Turner JE

    更新日期:1989-10-23 00:00:00

  • Excitotoxic hippocampal neuron loss following sustained electrical stimulation of the perforant pathway in the mouse.

    abstract::Prolonged electrical stimulation of the perforant pathway in the rat evokes epileptiform discharges in dentate granule cells and irreversibly damages hilar neurons. In this in vivo study, we demonstrate that similar perforant path stimulation in C57Bl/6 mice causes the same pattern of hippocampal neuron loss. Therefor...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kienzler F,Jedlicka P,Vuksic M,Deller T,Schwarzacher SW

    更新日期:2006-04-26 00:00:00

  • Vestibular afferents to the motoneurons of glossopharyngeal and vagus nerves in the frog, Rana esculenta.

    abstract::The aim of this work was to study whether the vestibular afferent fibers establish direct connections with the motoneurons of glossopharyngeal and vagus nerves of the frog, Rana esculenta. In anaesthetized animals the vestibulocochlear nerve and the common root of glossopharyngeal-vagus and accessory (IX-X-XI) nerves ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Deák A,Bácskai T,Veress G,Matesz C

    更新日期:2009-08-25 00:00:00

  • Transport of cargo from periphery to brain by circulating monocytes.

    abstract::The misfolding and aggregation of the Aβ peptide - a fundamental event in the pathogenesis of Alzheimer׳s disease - can be instigated in the brains of experimental animals by the intracranial infusion of brain extracts that are rich in aggregated Aβ. Recent experiments have found that the peripheral (intraperitoneal) ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Cintron AF,Dalal NV,Dooyema J,Betarbet R,Walker LC

    更新日期:2015-10-05 00:00:00

  • Locus coeruleus lesions decrease norepinephrine input into the medial preoptic area and medial basal hypothalamus and block the LH, FSH and prolactin preovulatory surge.

    abstract::The aim of this work was to study the role of the dorsal noradrenergic ascending pathway (DNAP), which originates in the locus coeruleus (LC) on the preovulatory surge of luteinizing hormone (LH) follicle-stimulating hormone (FSH) and prolactin (PRL) by producing bilateral electrolytic lesions (cathodal or anodal) in ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Anselmo-Franci JA,Franci CR,Krulich L,Antunes-Rodrigues J,McCann SM

    更新日期:1997-09-05 00:00:00

  • Biochemical and anatomical consequences of adult infraorbital nerve transection for serotonergic afferents within rat trigeminal subnuclei interpolaris and caudalis.

    abstract::Immunocytochemistry and high-performance liquid chromatography with electrochemical detection (HPLC-ED) were used, more than 76 days after infraorbital nerve (ION) transection, to examine the distribution and density of serotonin-immunoreactive (5-HTIR) axons, as well as serotonin (5-HT) and 5-hydroxyindoleacetic acid...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Klein BG,Blaker WD

    更新日期:1990-12-17 00:00:00

  • Preferential loss of GABAergic neurons in hypoxia-exposed neocortex slab cultures is attenuated by the NMDA receptor blocker D-2-amino-7-phosphonoheptanoate.

    abstract::The preferential loss of GABAergic neurons in neocortex slab cultures after exposure to hypoxia was reinvestigated and confirmed using an improved morphometric analysis based on stereological principles. This preferential cell loss could be attenuated by treating the hypoxic slab cultures with the N-methyl-D-aspartate...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Romijn HJ

    更新日期:1989-10-30 00:00:00

  • Influence of pyramidotomy on limb flexion movements induced by cortical stimulation and on associated postural adjustment in the cat.

    abstract::Flexion movements induced by cortical stimulation and the associated postural adjustments in bilaterally pyramidotomised cats have been studied by means of an apparatus which measures separately the changes of force under each limb in the upright position of the animal. The results show: (1) The general motor behaviou...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Nieoullon A,Gahéry Y

    更新日期:1978-06-23 00:00:00

  • Changes in the striatal extracellular levels of dopamine and dihydroxyphenylacetic acid evoked by ammonia and N-methyl-D-aspartate: modulation by taurine.

    abstract::Acute hyperammonemia is associated with motor disturbances that are thought to involve striatal dopaminergic dysfunction. Discharge of striatal dopaminergic neurons is controlled by N-methyl-D-aspartate (NMDA) receptors, the excessive activation of which contributes to ammonia neurotoxicity. Here we show that ammonium...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Anderzhanova E,Oja SS,Saransaari P,Albrecht J

    更新日期:2003-07-11 00:00:00

  • The proportion of neurons in the rat neostriatum that project to the substantia nigra demonstrated using horseradish peroxidase conjugated with wheatgerm agglutinin.

    abstract::Following the injection of small volumes of horseradish peroxidase conjugated with wheatgerm agglutinin into the substantia nigra of the rat, a high proportion of the total neuronal population in parts of the ipsilateral neostriatum was retrogradely labelled with horseradish peroxidase. Quantitative estimates in 1-mic...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Bolam JP,Powell JF,Totterdell S,Smith AD

    更新日期:1981-09-14 00:00:00

  • Direct relation of long-term synaptic potentiation to phosphorylation of membrane protein F1, a substrate for membrane protein kinase C.

    abstract::One hour after long-term potentiation (LTP) in the intact hippocampus, a selective increase in protein F1 in vitro phosphorylation was observed in homogenate prepared from dorsal hippocampus. Protein F1 phosphorylation was directly related to the magnitude and persistence of potentiation. No other phosphoprotein studi...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Lovinger DM,Colley PA,Akers RF,Nelson RB,Routtenberg A

    更新日期:1986-12-10 00:00:00

  • Functional rescue of the inactive splice variant of the dopamine D3 receptor D3nf.

    abstract::We previously found that the dopamine D3 receptor can be split at the third cytoplasmic loop into two fragments (D3trunk and D3tail), and that the mixture of the two fragments retains the binding and functional activity of the wild type receptor. The dopamine D3 receptor gene gives rise to several inactive receptor sp...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Scarselli M,Novi F,Corsini GU,Maggio R

    更新日期:2003-10-17 00:00:00

  • Time-frequency characteristics and dynamics of sleep spindles in WAG/Rij rats with absence epilepsy.

    abstract::In rat models of absence epilepsy, epileptic spike-wave discharges appeared in EEG spontaneously, and the incidence of epileptic activity increases with age. Spike-wave discharges and sleep spindles are known to share common thalamo-cortical mechanism, suggesting that absence seizures might affect some intrinsic prope...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sitnikova E,Hramov AE,Grubov V,Koronovsky AA

    更新日期:2014-01-16 00:00:00

  • Cholinotoxic effects of beta-amyloid (1-42) peptide on cortical projections of the rat nucleus basalis magnocellularis.

    abstract::Beta-amyloid(1-42) peptide (betaAP) was injected into the right nucleus basalis magnocellularis (nbm) of rats. After a 14-day survival time, the acetylcholinesterase and choline acetyltransferase activities and the number of muscarinic receptors were found biochemically to be significantly reduced in the ipsilateral f...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Harkany T,Lengyel Z,Soós K,Penke B,Luiten PG,Gulya K

    更新日期:1995-10-09 00:00:00

  • CRF-like immunoreactivity selectively labels preganglionic sudomotor neurons in cat.

    abstract::Immunohistochemical and neuronal tracing methods were used in cats to determine which type of postganglionic sympathetic neuron is innervated by preganglionic neurons which contain corticotrophin releasing factor-like immunoreactivity (CRF-LI). Preganglionic neurons with CRF-LI have their cell bodies at two restricted...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Shafton AD,Oldfield BJ,McAllen RM

    更新日期:1992-12-25 00:00:00

  • WITHDRAWN: Transplantation of bone mesenchymal stem cells containing the nerve growth factor gene in adult rat brain with Fimbria Fornix lesion.

    abstract::Bone marrow-derived mesenchymal stem cells (BMSCs) are a promising source for cell-based treatment of brain injury, but the therapy of BMSCs is restricted by low cell survival. We examined whether nerve growth factor (NGF) improve BMSCs viability in the brain with Fimbria-Fornix lesion (FF). After transduction of NGF ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Leng SL,Fan WG,Qu HG,Xu SC,Zhong WY,Zhang WY,Zeng JQ,Long DH,He HW

    更新日期:2009-01-19 00:00:00

  • Behavioral characterization of neuropeptide Y knockout mice.

    abstract::An extensive behavioral characterization was conducted with mice lacking the gene for neuropeptide Y (NPY) including response to 24 and 48 h fast and challenge with small molecule antagonists of NPY receptors implicated in mediating the feeding effects of NPY (i.e., Y1 and Y5). In addition, wildtype (WT) and NPY knock...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Bannon AW,Seda J,Carmouche M,Francis JM,Norman MH,Karbon B,McCaleb ML

    更新日期:2000-06-16 00:00:00

  • Electrophysiological effects of locally applied noradrenergic agents at cerebellar Purkinje neurons: receptor specificity.

    abstract::We have investigated the receptor subtype(s) mediating the noradrenergic inhibition of cerebellar Purkinje cell spontaneous firing rate using local application of specific agonists and antagonists, in situ, via pressure microejection. Extracellular action potentials were recorded from Purkinje neurons in anesthetized ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Parfitt KD,Freedman R,Bickford-Wimer PC

    更新日期:1988-10-18 00:00:00

  • Antihypertensive effects of L-tryptophan are not mediated by brain serotonin.

    abstract::L-Tryptophan produces a significant antihypertensive effect in spontaneously hypertensive rats while D-tryptophan does not change blood pressure. Both isomers of tryptophan significantly increase brain serotonin to the same extent at a time when the antihypertensive effect of L-tryptophan is maximal. Thus, the antihyp...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wolf WA,Kuhn DM

    更新日期:1984-03-19 00:00:00

  • Isradipine is able to separate morphine-induced analgesia and place conditioning.

    abstract::The effect of isradipine, a dihydropyridine calcium antagonist, on morphine-induced place preference and analgesia in rats and mice was studied. Isradipine (0.6-5.0 mg/kg s.c.) inhibited an acquisition of morphine-induced place preference in rats and mice in a dose-related manner. Isradipine did not affect or strength...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kuzmin A,Patkina N,Pchelintsev M,Zvartau E

    更新日期:1992-10-16 00:00:00

  • Progesterone alters GABA and glutamate responsiveness: a possible mechanism for its anxiolytic action.

    abstract::In this study, the neuromodulatory effects of progesterone were tested in an intact neuronal circuit of a model extrahypothalamic CNS area. Spontaneous discharge and responses of single cerebellar Purkinje neurons to microiontophoretically applied gamma-aminobutyric acid (GABA) and glutamate were monitored before, dur...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Smith SS,Waterhouse BD,Chapin JK,Woodward DJ

    更新日期:1987-01-06 00:00:00

  • Adenosine A1 and non-A1 receptors: intracellular analysis of the actions of adenosine agonists and antagonists in rat hippocampal neurons.

    abstract::Adenosine and its agonists exert a depressant effect on neuronal activity by interacting with the adenosine A1 receptor. There is now also evidence for electrophysiological effects mediated by adenosine receptors other than the A1 type, possibly A2 receptors. A1 and A2 receptor-induced changes in the electrical proper...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ameri A,Jurna I

    更新日期:1991-04-12 00:00:00

  • Weakening of functional corticomuscular coupling during muscle fatigue.

    abstract:OBJECTIVE:Recent research has shown dissociation between changes in brain and muscle signals during voluntary muscle fatigue, which may suggest weakening of functional corticomuscular coupling. However, this weakening of brain-muscle coupling has never been directly evaluated. The purpose of this study was to address t...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Yang Q,Fang Y,Sun CK,Siemionow V,Ranganathan VK,Khoshknabi D,Davis MP,Walsh D,Sahgal V,Yue GH

    更新日期:2009-01-23 00:00:00

  • Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat.

    abstract::Results from several studies indicate that cyclooxygenase-2 (COX-2) is involved in ischemic brain injury. The purpose of this study was to evaluate the neuroprotective effects of the selective COX-2 inhibitor nimesulide on cerebral infarction and neurological deficits in a standardized model of transient focal cerebra...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Candelario-Jalil E,González-Falcón A,García-Cabrera M,León OS,Fiebich BL

    更新日期:2004-05-08 00:00:00

  • A retrograde transport method for mapping zinc-containing fiber systems in the brain.

    abstract::A method for selectively labeling the CNS neurons that give rise to zinc-containing axonal boutons is described. Focal intracerebral infusions of selenium anions are used to produce a precipitate (presumably ZnSe) in zinc-containing axonal boutons at the injection site, and within 24-48 h, the precipitate is transport...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Howell GA,Frederickson CJ

    更新日期:1990-05-07 00:00:00

  • Changes in morphology of dendritic spines on honeybee calycal interneurons associated with cumulative nursing and foraging experiences.

    abstract::Using the rapid Golgi method, the morphology of dendritic spines was quantified in the calyxes of groups of newly emerged, nurse, and forager honeybees. These groups were studied because they represented distinct stages of behavioral development and cumulative experience which, according to recent vertebrate findings,...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Coss RG,Brandon JG,Globus A

    更新日期:1980-06-16 00:00:00

  • Muscarinic cholinergic receptors: autoradiographic localization of high and low affinity agonist binding sites.

    abstract::Previous studies have shown that muscarinic cholinergic agonists bind to 3 distinct receptor sites in brain, each being distinguished by their affinity for the agonists. Antagonists, on the other hand, bind to these sites with the same high affinity. The relative concentrations of the two high and the low affinity ago...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wamsley JK,Zarbin MA,Birdsall NJ,Kuhar MJ

    更新日期:1980-10-27 00:00:00

  • Activation of mitogen-activated protein kinases is not required for the extension of neurites from PC12D cells triggered by nerve growth factor.

    abstract::Numerous studies with PC12 cells have suggested that the mitogen-activated protein (MAP) kinase pathway might play a major role in the neuronal differentiation that is induced by nerve growth factor (NGF). Cells of the PC12D subline extend neurites within several hours in response to NGF in the presence of inhibitors ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sano M,Kitajima S

    更新日期:1998-03-02 00:00:00