Thirteen-month inhibition of aldose reductase by zenarestat prevents morphological abnormalities in the dorsal root ganglia of streptozotocin-induced diabetic rats.

Abstract:

:The dorsal root ganglia (DRG) have been identified as the target tissue in diabetic somatosensory neuropathy. It has been reported that, in the chronically diabetic state, DRG sensory neurons may undergo morphological changes. In this study, we examined the effect of zenarestat, an aldose reductase inhibitor, on the morphological derangement of the DRG and the sural nerve of streptozotocin-induced diabetic rats (STZ rats) over a 13-month period. The cell area of the DRG in STZ rats was smaller than that in normal rats. A decrease in fiber size was apparent in the sural nerve of the STZ rats, and the fiber density was greater. These morphological changes were reversed in zenarestat-treated STZ rats. The data suggest that, in peripheral sensory diabetic neuropathy, hyperactivation of the polyol pathway induces abnormalities not only in peripheral nerve fiber, but also in the DRG, which is an aggregate of primary sensory afferent cell bodies.

journal_name

Brain Res

journal_title

Brain research

authors

Shimoshige Y,Minoura K,Matsuoka N,Takakura S,Mutoh S,Kamijo M

doi

10.1016/j.brainres.2008.10.018

subject

Has Abstract

pub_date

2009-01-09 00:00:00

pages

182-7

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(08)02508-0

journal_volume

1247

pub_type

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