Thirteen-month inhibition of aldose reductase by zenarestat prevents morphological abnormalities in the dorsal root ganglia of streptozotocin-induced diabetic rats.

abstract：:In recent years, we have carried out several studies on brainstem mechanisms associated with pain modulation. Of particular interest has been the region of the nucleus tractus solitarius (NTS) at the level of the area postrema (AP) in the dorsomedial medulla. This region has been found to be rich in opiate receptors a...

journal_title：Brain research

authors： Bronzino JD,Oley N,Kelly ML,Cordova C,Morgane PJ

更新日期：1983-07-18 00:00:00

abstract：:In vitro quantitative autoradiography of high-affinity [3H]desmethylimipramine (DMI) binding sites was performed on 24 human brains postmortem. Highest densities of binding sites were found in portions of the amygdala, the granular layer of the dentate gyrus, the pyramidal layer of CA4. Next, in descending order were ...

journal_title：Brain research

authors： Gross-Isseroff R,Israeli M,Biegon A

更新日期：1988-07-19 00:00:00

abstract：:The distribution of carnosine-like immunoreactivity in photoreceptors of the frog retina was studied by post-embedding electron microscope immunocytochemistry. Different fixation and embedding procedures were applied and the best results were achieved on sections from tissue embedded in the hydrophilic resin LR White....

journal_title：Brain research

authors： Pognetto MS,Cantino D,Fasolo A

更新日期：1992-04-24 00:00:00

abstract：:Protein phosphatases (PPs) regulate many substrates implicated in learning and memory. Conditioned taste aversion (CTA) learning, in which animals associate a novel taste paired with a toxin and subsequently avoid the taste, is dependent on several serine/threonine phosphatase substrates and the PP1-binding protein sp...

journal_title：Brain research

authors： Oberbeck DL,McCormack S,Houpt TA

更新日期：2010-08-12 00:00:00

abstract：:Erythropoietin (EPO) provides neuroprotection and neurorestoration after traumatic brain injury (TBI). The EPO doses used for treatment of TBI significantly increase hematocrit, which may affect the efficacy of EPO therapy for TBI. The aim of this study was to investigate whether normalization of hematocrit would affe...

journal_title：Brain research

authors： Zhang Y,Xiong Y,Mahmood A,Meng Y,Qu C,Schallert T,Chopp M

更新日期：2009-10-19 00:00:00

abstract：:Cortical projection areas and distribution and response characteristics of masseteric nerve-driven neurons (MDN) were studied by recording surface-evoked potentials and single neuronal activities elicited by stimulation of the contralateral masseteric nerve in cats. Neuronal activities of MDNs could be recorded in two...

journal_title：Brain research

authors： Iwata K,Itoga H,Ikukawa A,Hanashima N,Sumino R

更新日期：1985-09-02 00:00:00

abstract：:This study evaluated the effects of intrathecal administration of a low-analgesic dose of the selective mu-agonist DAMGO co-administered with sequentially increasing doses of either the selective delta-agonist DPDPE or the selective kappa-agonist, U50,488H on mechanical nociceptive thresholds in the rat. Potent analge...

journal_title：Brain research

authors： Sutters KA,Miaskowski C,Taiwo YO,Levine JD

更新日期：1990-10-22 00:00:00

abstract：:Hydroxyl free radical production seems to play an important role in the pathogenesis of Parkinson's disease. In the present study, we investigated the dopamine agonists pramipexole and pergolide as well as the nitrone compound S-PBN (N-tert-butyl-alpha-(2-sulfophenyl)nitrone) to reduce hydroxyl radical formation. Micr...

journal_title：Brain research

authors： Ferger B,Teismann P,Mierau J

更新日期：2000-11-17 00:00:00

abstract：:To account for deficits in interval timing observed in Parkinson's Disease (PD) patients, we develop a model based on the accumulating firing rate of a neural population with recurrent excitation. This model naturally produces the curvilinear accumulation of neural activity introduced to timing psychophysics by Miall ...

journal_title：Brain research

authors： Shea-Brown E,Rinzel J,Rakitin BC,Malapani C

更新日期：2006-01-27 00:00:00

abstract：:Stereotaxic microinjections of the excitotoxin, ibotenic acid, were made into the striatum, hippocampus or cerebellum of the immature (7-day-old) rat. Two days later, pups were decapitated and the brains processed for light microscopic examination or neurochemical analyses. 10 micrograms ibotenate caused a complete lo...

journal_title：Brain research

authors： Steiner HX,McBean GJ,Köhler C,Roberts PJ,Schwarcz R

更新日期：1984-07-30 00:00:00

abstract：:Male rats were dehydrated for 22 h and then given 4 h intracerebroventricular (i.c.v.) infusions which commenced 2 h prior to the beginning of a 2-h fluid access period. I.c.v. infusion of iso-osmotic 0.27 M mannitol-CSF more than halved the amount of water normally drunk by dehydrated rats during the fluid access per...

journal_title：Brain research

authors： Osborne PG,Denton DA,Weisinger RS

更新日期：1987-05-26 00:00:00

abstract：:Fluctuation analysis has been used to study the influence of temperature on the conductance and mean open time of Cl- permeable ion channels induced by gamma-aminobutyric acid (GABA) and glycine in the membrane of tissue cultured mouse spinal neurons. The conductance of GABA- and glycine-activated channels increased s...

journal_title：Brain research

authors： Mathers DA,Barker JL

更新日期：1981-11-16 00:00:00

abstract：:Following single injections of horseradish peroxidase (HRP) in the superior colliculus (SC) and [3H]proline in the striate cortex of rats, a close correspondence was observed in the topographical arrangements of extrastriate cortical fields of HRP retrograde label and of isotope anterograde label. These results suppor...

journal_title：Brain research

authors： Olavarria J,Van Sluyters RC

更新日期：1982-06-24 00:00:00

abstract：:Although it has been reported that dendritic neurotransmitter releases from amacrine cells are regulated by the intracellular Ca(2+) concentration ([Ca(2+)](i)), their spatiotemporal patterns are not well explained. Fast Ca(2+) imagings of amacrine cells in the horizontal slice preparation of goldfish retinas under wh...

journal_title：Brain research

authors： Azuma T,Enoki R,Iwamuro K,Kaneko A,Koizumi A

更新日期：2004-10-08 00:00:00

abstract：:Acute bouts of exercise have been shown to produce transient increases in regional cerebral glucose utilization, oxygen uptake, and cerebral blood flow in motor cortex, striatum, and hippocampus. The purpose of this study was to determine whether or not chronic exercise will cause long-term metabolic plasticity in bra...

journal_title：Brain research

authors： McCloskey DP,Adamo DS,Anderson BJ

更新日期：2001-02-09 00:00:00

abstract：:The neural manifestations of food avoidance learning in the mollusc, Pleurobranchaea, survive the surgical reduction of the preparation to the nearly isolated brain. These manifestations include increased synaptic inhibition and reduced synaptic excitation of the phasic paracerebral feeding command interneurons (PCps)...

journal_title：Brain research

authors： Kovac MP,Davis WJ,Matera EM,Morielli A,Croll RP

更新日期：1985-04-08 00:00:00

abstract：:Mouse VD-hemopressin(α) (VD-Hpα) is an undecapeptide that selectively activates CB1 cannabinoid receptor in in vitro functional tests, and exerts CB1-mediated central antinociception in the mouse tail-flick assay. The aim of the present study was to further investigate the analgesic properties of supraspinal mouse VD-...

journal_title：Brain research

authors： Zheng T,Zhang R,Zhang T,Zhang MN,Xu B,Song JJ,Li N,Tang HH,Wang P,Wang R,Fang Q

更新日期：2018-02-01 00:00:00

abstract：:Aging is accompanied by an impairment of associative memory. The medial temporal lobe and fronto-striatal network, both involved in associative memory, are known to decline functionally and structurally with age, leading to the so-called associative binding deficit and the resource deficit. Because the MTL and fronto-...

journal_title：Brain research

authors： Meulenbroek O,Kessels RP,de Rover M,Petersson KM,Rikkert MG,Rijpkema M,Fernández G

更新日期：2010-02-22 00:00:00

abstract：:A rabbit polyclonal antibody (91-01) was raised against recombinant human glia maturation factor beta (r-hGMF-beta). The antibody did not cross-react with a number of other growth factors on ELISA test. When compared with the monoclonal antibody G2-09 previously obtained, 91-01 immunoblotted the same protein band in r...

journal_title：Brain research

authors： Wang BR,Zaheer A,Lim R

更新日期：1992-09-18 00:00:00

abstract：:The onset of adult hypothyroidism causes neuronal damage in the CA3 hippocampal region, which is attenuated by T(4) administration. We analyzed the expression of molecular proliferation markers (Cyclin D1 and PCNA), cellular damage-arrest (p53 and p21), and apoptosis (Bax/Bcl-2 index) in the hippocampus of hypothyroid...

journal_title：Brain research

authors： Alva-Sánchez C,Sánchez-Huerta K,Arroyo-Helguera O,Anguiano B,Aceves C,Pacheco-Rosado J

更新日期：2009-05-19 00:00:00

abstract：:After a moderate global cerebral ischemia, two hypothetical populations of pyramidal neurons are present among the hippocampal CA1 pyramidal neurons: one that will die and another one that will survive. Prior analysis of dissected hippocampal CA1 regions has shown a reduction of the GluR1-3 mRNA following ischemia. In...

journal_title：Brain research

authors： Alsbo CW,Wrang ML,Møller F,Diemer NH

更新日期：2001-03-09 00:00:00

abstract：:We have examined, at the light microscope level, putative direct synaptic interconnections, via motor axon collaterals, between type-identified triceps surae alpha-motoneurons labeled by intracellular injection of HRP. The results indicate that monosynaptic recurrent contacts can occur between synergist motoneurons (i...

journal_title：Brain research

authors： Cullheim S,Lipsenthal L,Burke RE

更新日期：1984-08-06 00:00:00

abstract：:Focal cerebral ischemia elicits an inflammatory response characterized by the infiltration and accumulation of leukocytes, as well as the secretion of inflammatory mediators (Clark et al., Brain Res. Bull., 35 (1994) 387-392; Garcia et al., Am. J. Pathol., 144 (1994) 188-199; Wang et al., J. Neurochem. 71 (1998) 1194-...

journal_title：Brain research

authors： Che X,Ye W,Panga L,Wu DC,Yang GY

更新日期：2001-06-01 00:00:00

abstract：:Changes in GABA(A) receptor alpha(1) subunit gene expression occur in the globus pallidus and substantia nigra pars reticulata following lesions of the nigrostriatal tract. To determine whether these changes are translated at the protein level, we performed quantitative autoradiography with the alpha(1) selective liga...

journal_title：Brain research

authors： Chadha A,Howell O,Atack JR,Sur C,Duty S

更新日期：2000-04-17 00:00:00

abstract：:Occlusion of the abdominal aorta proximal to the renal arteries results in an increase in arterial blood pressure, inhibition of forepaw and hindpaw withdrawal to a noxious mechanical stimulus, and inhibition of the tail-flick reflex to noxious heat. Occlusion of the abdominal aorta distal to the renal arteries does n...

journal_title：Brain research

authors： Thurston CL,Randich A

更新日期：1990-06-11 00:00:00

abstract：:We have previously described a rodent model of brief (30 min) middle cerebral artery occlusion followed by reperfusion, in which infarction develops gradually, reaching completion more than 3 days after ischemia, accompanied by morphological, biochemical, and pharmacological evidence of apoptosis. In the present study...

journal_title：Brain research

authors： Snider BJ,Du C,Wei L,Choi DW

更新日期：2001-11-02 00:00:00

abstract：:The effects of streptozotocin-induced diabetes mellitus on the activity of discrete regions of the brain were studied with histochemical localization and photodensitometric quantification of the metabolic enzyme, hexokinase. Two weeks after a single injection of streptozotocin (65 mg/kg, i.p.), plasma glucose and osmo...

journal_title：Brain research

authors： Krukoff TL,Patel KP

更新日期：1990-07-02 00:00:00

abstract：:The neuropeptide nociceptin/orphanin FQ (N/OFQ), the endogenous agonist of the N/OFQ peptide receptor (NOP receptor), has been demonstrated to be involved in many physiological and pathological functions including pain regulation. In the present study, the involvement of N/OFQ-NOP receptor system in electroacupuncture...

journal_title：Brain research

authors： Fu X,Wang YQ,Wu GC

更新日期：2006-03-17 00:00:00

abstract：:After studying pathway selection in the brain of Rana pipiens during unilateral optic nerve regeneration, several frogs were allowed to survive for lengthy periods for use in the present investigation. Retina flat-mounts were prepared from both eyes at 42-50 weeks postoperation. In some cases, HRP was infiltrated into...

journal_title：Brain research

authors： Scalia F,Arango V,Singman EL

更新日期：1985-10-07 00:00:00

abstract：:The effects of cocaine administration and withdrawal on D1 and D2 dopamine receptor number, affinity, and mRNA levels were examined in rats trained to self-administer cocaine for four weeks on a continuous reinforcement schedule. Two hours after the last infusion of cocaine there was a decrease in the number and agoni...

journal_title：Brain research

authors： Laurier LG,Corrigall WA,George SR

更新日期：1994-01-14 00:00:00