Abstract：
:Aging is accompanied by an impairment of associative memory. The medial temporal lobe and fronto-striatal network, both involved in associative memory, are known to decline functionally and structurally with age, leading to the so-called associative binding deficit and the resource deficit. Because the MTL and fronto-striatal network interact, they might also be able to support each other. We therefore employed an episodic memory task probing memory for sequences of object-location associations, where the demand on self-initiated processing was manipulated during encoding: either all the objects were visible simultaneously (rich environmental support) or every object became visible transiently (poor environmental support). Following the concept of resource deficit, we hypothesised that the elderly probably have difficulty using their declarative memory system when demands on self-initiated processing are high (poor environmental support). Our behavioural study showed that only the young use the rich environmental support in a systematic way, by placing the objects next to each other. With the task adapted for fMRI, we found that elderly showed stronger activity than young subjects during retrieval of environmentally richly encoded information in the basal ganglia, thalamus, left middle temporal/fusiform gyrus and right medial temporal lobe (MTL). These results indicate that rich environmental support leads to recruitment of the declarative memory system in addition to the fronto-striatal network in elderly, while the young use more posterior brain regions likely related to imagery. We propose that elderly try to solve the task by additional recruitment of stimulus-response associations, which might partly compensate their limited attentional resources.
journal_name
Brain Resjournal_title
Brain researchauthors
Meulenbroek O,Kessels RP,de Rover M,Petersson KM,Rikkert MG,Rijpkema M,Fernández Gdoi
10.1016/j.brainres.2009.12.011subject
Has Abstractpub_date
2010-02-22 00:00:00pages
100-10eissn
0006-8993issn
1872-6240pii
S0006-8993(09)02645-6journal_volume
1315pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The second of two targets (T2) presented in a rapid visual stream is often missed when presented shortly after the first (T1). This phenomenon has been referred to as the attentional blink. Here we show that the presentation of a synchronous sound enables T2 to escape the attentional blink, to the extent that performa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.01.070
更新日期：2008-11-25 00:00:00
abstract：:We sought to determine whether the global increase in regional cerebral blood flow (rCBF) produced by electrical stimulation of the rostral cerebellar fastigial nucleus (FN) is a consequence of excitation of intrinsic neurons of the FN or of axons of fibers passing through or projecting into it. Studies were conducted...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90312-0
更新日期：1989-10-23 00:00:00
abstract：:Basic fibroblast growth factor (bFGF) isolated from the brain and pituitary, has been shown to induce cell divisions in a variety of cell types. It also acts as a potent stimulator of angiogenesis, and it is important in the survival of several types of cultured neurons. Despite considerable information on the functio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90541-g
更新日期：1992-04-10 00:00:00
abstract：:In anaesthetized, spontaneously breathing cats and dogs, extracellular recordings were made of the spontaneous activities of 28 single neurones with cardiac rhythm. It was confirmed by histological examination that the neurones were situated in the mediodorsal portion of the nucleus of the solitary tract. Different di...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90049-x
更新日期：1977-09-09 00:00:00
abstract：:The axonal arborizations of the basket cells in the cerebral neocortex have long been considered as the source of the presynaptic terminals contacting the cell bodies of pyramidal cells. Given that the concept of the cortical basket cell is based upon indirect evidence only, it was deemed worthwhile to re-investigate ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90898-8
更新日期：1982-07-22 00:00:00
abstract：:Manual gestures occur on a continuum from co-speech gesticulations to conventionalized emblems to language signs. Our goal in the present study was to understand the neural bases of the processing of gestures along such a continuum. We studied four types of gestures, varying along linguistic and semantic dimensions: l...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.04.034
更新日期：2009-06-18 00:00:00
abstract：:Cigarette smoke passed through the nasal cavity of atenolol pre-treated anesthetized spontaneously breathing rabbits caused a bradycardia which was significantly modified by intracisternal application of the 5-HT1A receptor ligands 8-OH-DPAT (50 micrograms.kg-1) and buspirone (200 micrograms.kg-1). 8-OH-DPAT attenuate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91345-s
更新日期：1993-12-03 00:00:00
abstract：:The present study examines age-related changes in the subcellular localization of cathepsin B (cath B) and cathepsin D (cath D), as well as morphological features of the cathepsin-immunoreactive (ir) neurons in rat cerebral cortex. Sprague-Dawley rats were studied at 3 and 26 months. By immunoelectron microscopy cath ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01888-0
更新日期：1999-10-09 00:00:00
abstract：:Double impregnation staining of tissue was used to study on thick sections the three-dimensional configuration of the peripheral endoplasmic reticulum in neurosecretory neurons of the supraoptic nucleus in control and water-deprived rats. According to the spatial organization of the endoplasmic reticulum, two types of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90105-7
更新日期：1979-07-13 00:00:00
abstract：:Entopeduncular nucleus (EPN) cells which project to thalamic and non-thalamic sites were identified by antidromic discharge. Each population of cells, projecting to the ventral anterior nucleus of the thalamus (VA), centrum medianum (CM), the lateral habenula (LHB), and the pedunculopontine nucleus (PP), was distribut...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90993-9
更新日期：1978-11-17 00:00:00
abstract：:Astrocytes associated with beta-amyloid (Aβ)-deposited senile plaques are a common neuropathological feature of Alzheimer's disease (AD). There is little doubt that the association of Aβ with the major component in the central nervous system cells significantly influences disease progression, however, the molecular me...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.12.062
更新日期：2012-03-02 00:00:00
abstract：:Tetanic but not low frequency stimulation of the perforant path in rat hippocampal slices results in changes in the metabolism of phosphoinositides and phosphatidic acid. The phosphorylation of other, non-inositol lipids was not affected by the high frequency stimulation. The observed changes in phosphoinositide metab...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90198-7
更新日期：1984-11-12 00:00:00
abstract：:The second messenger cyclic GMP (cGMP) plays a role in the anxiolytic-like behavioral response of mice to nitrous oxide (N2O). This study was conducted to determine whether this behavioral effect of N2O is affected by inhibition of cGMP-dependent protein kinase (PKG). N2O-induced behavior in the light/dark exploration...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.01.015
更新日期：2005-03-15 00:00:00
abstract：:Retinal and tectal potentials to alternating gratings were recorded in pigeons raised monocularly deprived. Deprived eyes showed consistent myopia and anterior-posterior axis elongation. In addition, vitreal opacities were observed in 70% of the deprived eyes. In pigeons with vitreal opacities, a reduction of retinal ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90165-9
更新日期：1985-07-15 00:00:00
abstract：:Serotonin (5-HT) 1A receptors have been implicated in a variety of conditions including, depression, suicidal behavior, and aggression. Post-mortem brain studies and in vivo imaging studies report a variety of age and sex effects on brain 5-HT(1A) binding. Behavioral data from 5-HT(1A) specific pharmacological challen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03243-2
更新日期：2002-11-08 00:00:00
abstract：:The relative potencies of the stereoisomers of ketamine, N-allylnormetazocine and cyclazocine were determined at mu opiate and sigma opiate/phencyclidine (PCP) receptors in vitro in rat brain homogenates, as well as in a discriminative stimulus behavioral paradigm in rats trained to discriminate PCP from saline. In al...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91326-x
更新日期：1984-02-27 00:00:00
abstract：:Regulation of myelin protein gene expression in the presence and absence of myelin assembly can be assessed using crushed or permanently transected adult sciatic nerves of rats. The P0 glycoprotein and the myelin basic protein (MBP) are the major myelin-specific proteins of the peripheral nervous system. The steady-st...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0169-328x(87)90021-0
更新日期：1987-04-01 00:00:00
abstract：:Several studies have demonstrated in the past that endogenous opioid peptides and opioid receptors may be involved as mediators of brain tissue growth and function in the neonate. Applying histological and autoradiographic methods, we have examined the effect of the mu-receptor-specific antagonist, naltrexone, on the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90515-5
更新日期：1989-05-08 00:00:00
abstract：:The time course of the neurogenesis of cells showing glutamic acid decarboxylase (GAD) immunoreactivity has been analyzed in the dorsal hippocampus and area dentata of the mouse. The quantitative data indicate that gamma-aminobutyric acid (GABA)ergic cells are generated prenatally, and that their peaks of neurogenesis...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(86)80012-9
更新日期：1986-11-01 00:00:00
abstract：:The implantation of dopamine-rich mesencephalic grafts into the 6-hydroxydopamine (6-OHDA)-lesioned neostriatum of rats was accompanied by marked hyperinnervation by serotonin (5-HT) fibers. The purpose of this study was to examine the possibility that the graft-derived 5-HT hyperinnervation is governed by target-rela...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91667-4
更新日期：1992-10-02 00:00:00
abstract：:We employed a highly sensitive combination method of retrograde tracing and immunohistochemistry to identify calcitonin gene-related peptide (CGRP)-containing fiber pathways in the rat from the ventrolateral part of the ventrolateral thalamic nucleus (vl-vl) and the caudal continuation to the insular cortex. Biotin-wh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91211-9
更新日期：1985-09-30 00:00:00
abstract：:The role of adrenal hormones in mediating the increase in blood glucose levels following several stressful stimuli (environmental and pharmacological) was studied. The role for brain norepinephrine systems in the initiation of the BG response to these challenges was investigated as well. There is disagreement as to wh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90464-2
更新日期：1989-11-13 00:00:00
abstract：:A single informon reproduces classical conditioning to compound stimuli under a wide range of conditions during reinforcement and non-reinforcement; it also reproduces simple operant conditioning. A network of 210 informons with 8400 simultaneouslly varying pathways has been simulated; it can learn to recognize handpr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90574-6
更新日期：1976-01-30 00:00:00
abstract：:The study makes an attempt to find out the action of norepinephrine (NE) and phenoxybenzamine (PB), applied at medial preoptic area (mPOA), in altering the sleep-awake responses, in free moving rats, which has not yet been reported. Effects of application of NE during day and PB during night, at mPOA, on sleep-awake r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90125-2
更新日期：1984-11-26 00:00:00
abstract：:To determine the involvement of vasoactive intestinal polypeptide (VIP) in the development of kindling in rats, VIP or antibody to VIP (anti-VIP) was injected into the third ventricle after the daily stimulation of the basolateral amygdala. The number of stimulations required to reach full amygdaloid kindling was sign...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91082-c
更新日期：1991-02-08 00:00:00
abstract：:The particular vulnerability of hippocampal CA3/CA4 neurons to intracerebroventricularly administered kainate did not occur in rats until postnatal day 16. Glutamate applied in the same way failed to show comparable neurodegenerative signs, even when administered in large doses to adult animals. Alternatively, both ka...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(84)90004-x
更新日期：1984-05-01 00:00:00
abstract：:Systemic administration of kainic acid in the rat results in the development of a characteristic excitotoxic syndrome, consisting of automatisms (wet dog shakes, WDS), sustained limbic seizures and brain damage. Since kainate increases the release of excitatory amino acid neurotransmitters such as glutamate, this synd...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90227-5
更新日期：1994-08-01 00:00:00
abstract：:Luteinizing hormone (LH) secretion during the reproductive cycle and in ovariectomized (OVX) rats is pulsatile and this pattern of secretion is determined by intermittent discharges of LH-releasing hormone (LHRH) into the hypophysial portal vessels. LHRH secretion is probably controlled by prior pulsatile norepinephri...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01548-6
更新日期：1999-06-26 00:00:00
abstract：:Calretinin has been identified as a brain specific calcium-binding protein which appears as a prominent protein in the cochlear nucleus. We identified and localized calretinin in the guinea pig and rat inner ear using polyclonal antibodies. Immunoblot analyses of guinea pig and rat auditory nerve homogenates revealed ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91224-o
更新日期：1991-09-27 00:00:00
abstract：:A comparison was made of the effects of left and right cerebral decortication on cytotoxic activity of natural killer and natural cytotoxic lymphocytes in the mouse. Natural killer cytotoxic activity was significantly reduced after right decortication, whereas left decortication led to a less pronounced, though still ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90704-f
更新日期：1990-08-06 00:00:00
